Yes and Know Curriculum for Sexually Transmitted Infections

(Yes and Know Trial)

Overseen By Karin K Coyle, PhD

Age: < 65

Sex: Any

Trial Phase: Academic

Sponsor: ETR Associates

Disqualifiers: Non-English speaking, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 12

Duration: 9 weeks

1200 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new sexual health education program called Yes and Know. It aims to help young people learn about reproductive health, healthy relationships, and using health services. Participants will split into two groups: one will receive the Yes and Know program, and the other will receive a program about nutrition. The trial seeks to determine if the sexual health program can reduce unprotected sex and improve knowledge and self-confidence in making healthy choices. English-speaking youth between the ages of 14 and 19 are eligible to participate. As an unphased trial, this study offers young people a unique opportunity to contribute to important educational research that could shape future health programs.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What prior data suggests that the Yes and Know curriculum is safe for youth?

Research has shown that the Yes and Know curriculum focuses on teaching sexual health rather than medical treatments. As an educational program, it lacks the typical safety concerns associated with drug trials. Studies primarily assess how effectively the program educates students about sexual health and do not report any side effects or safety issues. This is expected, as the program involves no medication or medical procedures. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the "Yes and Know" curriculum for sexually transmitted infections (STIs) because it offers a fresh educational approach tailored specifically for youth. Unlike traditional STI prevention methods that often rely on clinical treatments or generic health classes, this curriculum provides targeted, age-appropriate education designed to engage young people in understanding and preventing STIs. By focusing on interactive learning and real-world applications, it aims to empower adolescents with knowledge and decision-making skills, which could lead to more effective prevention and healthier choices.

What evidence suggests that this trial's programs could be effective for improving sexual health education?

Research has shown that sexual health education programs, such as the Yes and Know curriculum, which participants in this trial may receive, can reduce unprotected sex and increase knowledge about sexually transmitted infections (STIs). Evidence from similar programs indicates they can decrease unplanned pregnancies and STIs among young people. A pilot study found that students who attended STI presentations gained significantly more knowledge about sexual health. The Yes and Know curriculum uses interactive sessions and resources to engage young people, aiming to improve their understanding and confidence in dealing with reproductive health issues. These findings suggest that participating in such programs can lead to healthier choices and better use of reproductive health services. ^{1 2 6 7 8}

Who Is on the Research Team?

Rebecca A Braun, DrPH, MPH

Principal Investigator

ETR Associates

Karin K Coyle, PhD

Principal Investigator

ETR Associates

Are You a Good Fit for This Trial?

This trial is for English-speaking youth aged 14-19 who are interested in learning about sexual health and well-being. It's designed to see if the Yes and Know program can help reduce unprotected sex and improve knowledge of reproductive health, self-efficacy, and use of health services.

Inclusion Criteria

English speaking

I am between 14 and 19 years old.

Exclusion Criteria

Anyone not meeting inclusion criteria.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive the Yes and Know or Nutrition Skills program through nine 60-minute synchronous virtual sessions, along with asynchronous online activities and resources

9 weeks

9 virtual sessions

Follow-up

Participants complete online surveys to assess the program's effectiveness in reducing unprotected sex and improving health knowledge and self-efficacy

12 months

Online surveys at 3 and 12 months post-intervention

What Are the Treatments Tested in This Trial?

Interventions

• Yes and Know

Trial Overview The study compares two educational programs: 'Yes and Know', focusing on sexual health, delivered virtually over nine hours plus online activities; versus a nutrition education program. The effectiveness will be measured through surveys before, three months after, and one year after the sessions.

How Is the Trial Designed?

Group I: Yes and Know curriculum Experimental Treatment 1 Intervention

Youth will receive the Yes and Know curriculum.

Group II: Nutrition Education for Adolescents Active Control 1 Intervention

Youth will receive education about adolescent nutrition.

Who Is Running the Clinical Trial?

ETR Associates

Lead Sponsor

Trials

14

Recruited

12,900+

University of California, San Francisco

Collaborator

Trials

2,636

Recruited

19,080,000+

Citations

1. withpower.com withpower.com/trial/phase-sexually-transmitted-diseases-2025-e7c62

Yes and Know Curriculum for Sexually Transmitted Infections The study will assess the program's effectiveness in reducing the prevalence of unprotected sex among youth and improving short-term outcomes, such as knowledge ...

2. etr.org etr.org/blog/how-to-innovate-sexual-health-education/

How to Innovate Sexual Health Education Evidence-based pregnancy and sexually transmitted infection (STI) prevention programs have been shown to have a positive effect on reducing unplanned ...

3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC8057898/

Assessing and Improving the Knowledge of Sexually ... Our pilot study sought to assess the impact of a live presentation about STIs in high school students and to evaluate students' baseline and acquired knowledge.

4. etr.org etr.org/blog/appropriateness-reviews-for-yes-and-know-curriculum/

Conducting Appropriateness Reviews for ETR's Yes and ... Here's a closer look on her insight on sexual health education in the South, the Yes and Know curriculum, and how appropriateness reviews can impact youth!

5. clinicaltrials.gov clinicaltrials.gov/study/NCT02009046

Randomized Evaluation of a Multi-Component, Rights ... This study examines the effectiveness of the Sexuality Education Initiative (SEI), a comprehensive, multi-component, rights-based sexuality education program.

6. researchgate.net researchgate.net/publication/372544105_YES_Program_Adolescent_Lessons_Learned_during_a_Virtual_Sexual_Health_Program

YES! Program: Adolescent Lessons Learned during a ... The results highlight students' learning experiences through participation in the YES! Program and the skill outcomes of comprehensive sexual ...

7. mdpi.com mdpi.com/2411-5118/4/3/23

Adolescent Lessons Learned during a Virtual Sexual ... This qualitative study employs focus groups to examine learning experiences of nine participating adolescents from a comprehensive youth empowerment and sexual ...

8. ospi.k12.wa.us ospi.k12.wa.us/sites/default/files/2022-12/2019-12-Sexual-Health-Education-Data-Survey.pdf

2019 Sexual Health Education Data Survey 83% reported providing some type of sexual health instruction, ranging from single-topic instruction such as HIV prevention, abstinence, or sex trafficking, to ...