Tech-PN for Adnexitis

Phase-Based Estimates
1
Effectiveness
1
Safety
Johns Hopkins School of Medicine, Baltimore, MD
Adnexitis+1 More
Tech-PN - Behavioral
Eligibility
< 65
Female
Eligible conditions
Adnexitis

Study Summary

This study is evaluating whether a technology-enhanced community health nurse intervention can help reduce rates of short-term repeat infection by improving adherence to PID treatment and reducing unprotected intercourse. original

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Eligible Conditions

  • Adnexitis
  • Pelvic Inflammatory Disease
  • Pelvic Infection

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Tech-PN will improve 3 primary outcomes in patients with Adnexitis. Measurement will happen over the course of 90 days.

3 months
Rate of STI Mycoplasma genitalium
Rate of STI Trichomonas vaginalis
90 days
Vaginal health as assessed by proportion of high Lactobacilli community state-type 1 properties (CST)

Trial Safety

Safety Estimate

1 of 3

Trial Design

2 Treatment Groups

Control
TECH-PN

This trial requires 150 total participants across 2 different treatment groups

This trial involves 2 different treatments. Tech-PN is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

TECH-PN
Behavioral
Participants receive community health nurse visits, text-messaging support, additional testing and field based visits with a nurse practitioner.
ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 3 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 3 months for reporting.

Closest Location

Johns Hopkins School of Medicine - Baltimore, MD

Eligibility Criteria

This trial is for female patients aged 65 and younger. You must have received 1 prior treatment for Adnexitis or the other condition listed above. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Mild-moderate PID
Outpatient treatment disposition
Permanently reside in the Baltimore Metropolitan area
Willing to sign informed consent & be randomized

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of adnexitis?

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Bacteria in patients with pelvic adnexal abscesses are distributed in the same pattern as in pelvic inflammatory disease. Pelvic adnexal abscesses (or pelvic abscesses in general) must be considered as a presentation of a pelvic infectious process.

Unverified Answer

Is tech-pn safe for people?

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This is the first study to show a link between the number of devices in a home and risk of suicide, self-harm, and unintentional injury. These links exist between women and those with disability; women and people over the age of 55; those with lower income and ethnic minorities. Further research is needed to determine the underlying causality of this association and whether specific intervention measures could decrease injury risk.

Unverified Answer

What causes adnexitis?

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Adnexitis occurs when a female's gonadotrophs (Lun-V E2) are incapable of making estrogen. It is caused by a combination of ovarian failure, high androgen levels, and the increased rate of fetal reabsorption of estrogens compared with the time before ovulation. It is characterized by decreased fetal testosterone levels and estrogen levels, resulting in delayed fetal masculinization of all the male genitalia and absence of the Müllerian ducts and fallopian tubes.

Unverified Answer

Can adnexitis be cured?

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Adnexitis is more likely to be cured if the underlying process is identified and the medication appropriate. There are few cases in recorded history of adnexitis being cured regardless of the cause of the adnexitis.

Unverified Answer

What is adnexitis?

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A very common bacterium, Escherichia coli, causes adnexitis - an infection of the outer intestine or genital lining. The majority of cases are self-limiting and resolve spontaneously, and treatment is often unnecessary.

Unverified Answer

How many people get adnexitis a year in the United States?

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Nearly 10 million people in the United States will be diagnosed with adnexitis annually. About 16,600 of those cases will be diagnosed in women (27:1 female to male) and 8,800 will be diagnosed in men (12:1 female to male). These estimates will underestimate the true number of cases because the Centers for Disease Control and Prevention does not track reporting of adnexitis.

Unverified Answer

What are common treatments for adnexitis?

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The data demonstrate the existence of common treatments used for adnexitis and the need to have more knowledge about the most effective treatments and the risks of various treatments.

Unverified Answer

What are the common side effects of tech-pn?

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Side Effects of PEG-CPA are less common than those of ECP and are typically mild. Among the rare side effects that occur, the most frequently reported are asthenia, dizziness, fatigue, abdominal pain, and edema. If there is a delay in treatment or if side effects are more severe the treatment may have to be stopped.

Unverified Answer

Has tech-pn proven to be more effective than a placebo?

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In a recent study, findings, TPN did not seem to have an overall effect on relieving symptoms of IBS and ICTDs. The combination of TC and TPN may offer benefits compared with placebo. More prospective studies are required to confirm these findings.

Unverified Answer

Who should consider clinical trials for adnexitis?

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Clinical trial participation is not indicated for uncomplicated cases of adnexitis. Clinically validated treatments are available, and, as noted above in the article 'A diagnosis of fungal infection', the best results (maximum clinical improvement and maximum clinical benefit) often occur with antimycotic therapies.

Unverified Answer

Have there been other clinical trials involving tech-pn?

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Tech-pn may be effective in some patients with an exaggerated form of bronchial asthma. There seem to be other types of tech-pn which are useful in some patients with asthma with other health issues such as, chronic obstructive pulmonary disease (COPD), allergic asthma, and so on.\n

Unverified Answer

Is tech-pn typically used in combination with any other treatments?

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A wide range of treatments, some that are already common, were used in combination with Tech-PN. More research is needed to determine the use of these treatments in combination with Tech-PN to improve its clinical utility.

Unverified Answer
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