This trial is evaluating whether Fisetin will improve 1 primary outcome and 19 secondary outcomes in patients with Arthrosis. Measurement will happen over the course of 32 days post baseline.
This trial requires 100 total participants across 4 different treatment groups
This trial involves 4 different treatments. Fisetin is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
Fisetin is a small molecule derived from flaxseed that has been used as an oral antioxidant. In addition to this, other studies have shown that it plays a role in blood pressure regulation, which is interesting considering its effect on inflammation. Findings from a recent study also shows the ability of fisetin to improve the functionality of articular joints in vitro.
Arthrosis is a condition where a bone becomes diseased and deformed. This condition causes pain and can lead to difficulty for the person to do things like stand, walk, sleep, and bend. There are different types of symptoms that people with arthrosis must deal with, such as pain. Even though these symptoms do not affect how the person interacts with the world, they hurt them. A lot of time is spent on managing the pain and trying to fix the bone.\n\nThere are many different ways to prevent and treat arthritis (arthritis is an inflammation of a joint). The best method of treatment depends on the type of arthritis the person has.
Arthrosis is the condition of joints that can result from chronic inflammation and can cause joint pain, swelling, restriction and stiffness. Arthritis-like symptoms can often be observed in those without joint disease, although these symptoms are generally milder than in joint disease, and may also be the first symptoms of arthritis.
Arthrosis appears to be a multi-factorial disease with contributions from multiple risk factors. However, smoking remains the most significant risk factor and it is probably the major cause of early arthrosis.
Around 30 million people have at least one type of joint discomfort in the US. This is 7 times more people than are diagnosed with arthritis. Only around 50% of those who experience a joint worry or feel pain get an exam with a healthcare professional.
In patients with acute knee instability, successful treatment of the associated arthrosis is reported to be possible. However, most patients do not make excellent responders to this treatment. In persistent cases, additional arthrodialytic therapy may be useful.
There is little evidence available for many arthritis treatments and alternatives, such as acupuncture, chiropractic, massage, orthotics and lifestyle, are often used. Although there is a vast number of alternative treatments, they may still represent the most common treatments for arthritis.
Fisetin is the most abundant flavonol and can be found in foods such as tea, soy, onion, egg, apple peel, pomegranate, cocoa, bilberry, spinach, broccoli, and broccoli sprouts. It has many health benefits, including antitumor, antioxidant, and anti-inflammatory activities. In the present study, fisetin exhibited anti-inflammatory effect, inhibiting the expressions of c-Jun N-terminal kinase, p38 mitogen-activated protein kinase, and nuclear factor-kB, and consequently down-regulating inflammatory factors, including TNF-α and IFN-γ.
It is proposed that fisetin reduces osteoclast-related bone resorption by inactivating ROS formation and inhibiting the Akt pathway in osteoclasts via the down-regulation of NFATc1 and NFATc2.
Arthrosis is an oft neglected chronic inflammatory joint disease, which involves cartilage loss that is irreversible and is associated with a significant and often severe negative impact on the individual's quality of life. It is important to recognize the many possible signs and symptoms of arthrosis, especially to recognize the presence of pain at any stage of arthritis.
To our knowledge, this is the first review to provide evidence of clinical trials for fisetin safety and efficacy for various musculoskeletal indications including osteoarthritis.
Fisetin is one of the most widely used herbal medicine in many herbal products due to its effects in reducing inflammation. But, fisetin has been suggested to cause side-effects due to its multiple actions such as inhibition of 5'-lipoxygenase activity and enhancement of 5'-hydroperoxidase activity. Thus, it is essential to consider the possible side effects of fisetin before it can be used for treatments. Data from a recent study, the side effect and possible interactions of fisetin on the production of PGE2 and the expression of EP4 receptor have been demonstrated in THP-1 cells and C3H10T1/2 cells and we suggest a possible approach for treating arthritis.