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Non-Invasive Brain Stimulation for Cyclic Vomiting Syndrome

N/A
Recruiting
Led By David J Levinthal, MD PhD
Research Sponsored by University of Pittsburgh
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of CVS
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up multiple study sessions spanning up to 12 months
Awards & highlights

Study Summary

This trial will see if there are differences in brain activity between people with CVS and healthy people, as measured by a non-invasive brain stimulation method.

Who is the study for?
This trial is for individuals diagnosed with cyclic vomiting syndrome (CVS). It's not open to those who have a history of head injury, metal in the skull, stroke, seizures, or use certain drugs like clozapine or amphetamines. Pregnant women and people with psychosis or cognitive issues can't join either.Check my eligibility
What is being tested?
The study is testing how the brain's electrical activity differs between CVS patients and healthy people using Transcranial Magnetic Stimulation (TMS), which is a non-invasive brain stimulation technique.See study design
What are the potential side effects?
Since TMS is non-invasive, side effects are usually mild but may include discomfort at the stimulation site, headache, lightheadedness, or rarely seizures.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been diagnosed with cyclic vomiting syndrome (CVS).

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~multiple study sessions spanning up to 12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and multiple study sessions spanning up to 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Paired-pulse ratios
Secondary outcome measures
Cortical silent period
Heart rate variability
TMS motor threshold

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: CVS subjectsExperimental Treatment2 Interventions
Subjects diagnosed with Cyclic Vomiting Syndrome (CVS)
Group II: healthy, non-CVS subjectsActive Control2 Interventions
Subjects not diagnosed with CVS

Find a Location

Who is running the clinical trial?

University of PittsburghLead Sponsor
1,722 Previous Clinical Trials
16,342,836 Total Patients Enrolled
David J Levinthal, MD PhDPrincipal InvestigatorUniversity of Pittsburgh
1 Previous Clinical Trials
155 Total Patients Enrolled

Media Library

Autonomic activity Clinical Trial Eligibility Overview. Trial Name: NCT05256160 — N/A
Cyclic Vomiting Syndrome Research Study Groups: CVS subjects, healthy, non-CVS subjects
Cyclic Vomiting Syndrome Clinical Trial 2023: Autonomic activity Highlights & Side Effects. Trial Name: NCT05256160 — N/A
Autonomic activity 2023 Treatment Timeline for Medical Study. Trial Name: NCT05256160 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How large is the participant pool for this medical research?

"Affirmative. Information hosted on clinicaltrials.gov indicates that this research trial, initially posted in May of 2022, is actively recruiting participants; they are attempting to recruit 110 people from a single location."

Answered by AI

Does this clinical trial offer enrollment to individuals over 30 years of age?

"According to the inclusion criteria, qualified candidates for this trial must be between 18 and 60 years old. However, there are 395 clinical trials available for those below 18 and 1056 specifically targeting individuals above 65."

Answered by AI

Is this experiment currently seeking participants?

"Affirmative. Clinicaltrials.gov displays that this clinical trial initiated on May 16th 2022 and is currently enrolling individuals. 110 participants are needed from 1 medical site to complete the study's objectives."

Answered by AI

Who qualifies to take part in this experiment?

"To take part in this investigation, 110 individuals aged 18 to 60 years must have been medically diagnosed with cyclic vomiting syndrome (CVS) and currently suffer from vomiting."

Answered by AI

Who else is applying?

What state do they live in?
District of Columbia
What site did they apply to?
University of Pittsburgh Medical Center
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
3+

Why did patients apply to this trial?

I've tried so many drugs. Botox for my migraines is currently backfiring and this condition is destroying my life.
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
Cortical Excitability in Cyclic Vomiting Syndrome
David Levinthal 2022. "Cortical Excitability in Cyclic Vomiting Syndrome". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05256160.
All > Cyclic Vomiting Syndrome
~40 spots leftby Jun 2025
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