Non-Invasive Brain Stimulation for Cyclic Vomiting Syndrome
What You Need to Know Before You Apply
What is the purpose of this trial?
This exploratory study will determine if there are differences in cortical excitability between patients suffering from cyclic vomiting syndrome (CVS) and healthy control subjects, as assessed by a non-invasive method of brain stimulation (Transcranial Magnetic Stimulation, TMS).
Will I have to stop taking my current medications?
You may need to stop taking certain medications that lower the seizure threshold, like clozapine, chlorpromazine, amphetamines, and some recreational drugs. The trial does not specify other medications, so check with the study team about your specific situation.
Is non-invasive brain stimulation safe for humans?
How does non-invasive brain stimulation differ from other treatments for cyclic vomiting syndrome?
Non-invasive brain stimulation for cyclic vomiting syndrome is unique because it targets brain connectivity and autonomic nervous system regulation, which are linked to the condition's symptoms. Unlike traditional treatments that may focus on gastrointestinal symptoms, this approach aims to modulate brain activity and improve autonomic function, potentially addressing the root cause of the syndrome.678910
What data supports the effectiveness of the treatment for Cyclic Vomiting Syndrome?
Research suggests that Cyclic Vomiting Syndrome (CVS) involves altered brain connectivity and autonomic nervous system function, similar to migraines. Non-invasive brain stimulation, like TMS (transcranial magnetic stimulation), which targets brain areas involved in these processes, has shown promise in treating migraines, indicating potential effectiveness for CVS.68101112
Who Is on the Research Team?
David J Levinthal, MD PhD
Principal Investigator
University of Pittsburgh
Are You a Good Fit for This Trial?
This trial is for individuals diagnosed with cyclic vomiting syndrome (CVS). It's not open to those who have a history of head injury, metal in the skull, stroke, seizures, or use certain drugs like clozapine or amphetamines. Pregnant women and people with psychosis or cognitive issues can't join either.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo Transcranial Magnetic Stimulation (TMS) to assess cortical excitability
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Autonomic activity
- TMS Paired-Pulse assessment of cortical excitability
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Pittsburgh
Lead Sponsor