Speech Discrimination Assessments for Fragile X Syndrome
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to better understand how children with Fragile X Syndrome perceive and learn speech. Researchers will use tests to assess speech and language skills and brain scans to observe how these children process sounds differently. Participants will listen to speech sounds while researchers monitor their brain activity. Children with Fragile X Syndrome or those born prematurely, who can sit independently and speak English at home, might be suitable candidates. This study seeks to explain why speech and hearing are unique in these children. As an unphased study, this trial offers a unique opportunity to contribute to groundbreaking research that could enhance understanding and support for children with Fragile X Syndrome.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that this speech discrimination assessment is safe for children with Fragile X Syndrome?
Research has shown that speech discrimination therapy is safe in many situations. Although specific safety data for treating Fragile X Syndrome with this therapy is lacking, no major reports of negative effects have emerged, indicating that the therapy is generally well-tolerated. Speech discrimination therapy involves listening to speech sounds, which is neither invasive nor harmful. In studies, researchers typically measure participants' brain activity to assess how they process these sounds. This process resembles everyday listening and is considered safe for participants.12345
Why are researchers excited about this trial?
Researchers are excited about this trial because it explores a new way to understand and potentially help with Fragile X Syndrome through speech discrimination assessments. Unlike traditional treatments that might focus on behavioral therapy or medication, this approach involves participants listening to speech sounds while tracking brain responses. This could provide fresh insights into how the brains of individuals with Fragile X Syndrome process speech, potentially leading to new therapeutic strategies. By measuring electrical and hemodynamic changes in the brain, this study hopes to uncover unique patterns that could pave the way for innovative treatment options in the future.
What evidence suggests that speech discrimination is effective for Fragile X Syndrome?
Research has shown that training to better understand speech can improve talking and language skills in people with Fragile X Syndrome. For example, one study using computer-based listening exercises found that participants improved in recognizing vowel and consonant sounds. This suggests that similar methods might help people with Fragile X understand speech better. Another study using rats with Fragile X found that their brains had trouble processing speech sounds, indicating that focused speech training could help address these issues. Although direct evidence in humans with Fragile X remains limited, these studies suggest that speech training techniques could enhance communication skills. Participants in this trial will engage in speech discrimination exercises, listening to speech sounds while investigators measure electrical and hemodynamic changes in the brain.16789
Are You a Good Fit for This Trial?
This trial is for children who have Fragile X Syndrome, can sit by themselves, and come from homes where English is spoken. It's also open to those with typical development or a history of premature birth. Children who've had seizures in the last six months or were born before 36 weeks (except for preemies) cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Assessment
Participants undergo behavioral assessment of speech and language abilities, neuroimaging, and hearing tests using EEG/fNIRS during presentation of speech and nonspeech sounds.
Follow-up
Participants are monitored for changes in developmental skills and auditory processing through outcome measures.
What Are the Treatments Tested in This Trial?
Interventions
- Speech discrimination
Find a Clinic Near You
Who Is Running the Clinical Trial?
Children's Hospital Medical Center, Cincinnati
Lead Sponsor