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Pre-surgical Aerobic Exercise for Cancer

Phase < 1
Waitlist Available
Led By Lee W. Jones, PhD
Research Sponsored by Memorial Sloan Kettering Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
- At least a 2-week window from study enrollment to scheduled surgical resection (patients with prespecified solid tumors only)
- Patients with operable untreated prostate cancer scheduled for surgery
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

This trial is designed to find the safest level of aerobic exercise for people with cancer and to see if there are any benefits to aerobic exercise for these patients. The study will use different doses of aerobic exercise to compare the effects and feasibility of the exercise. The study will also use apps and electronic devices to monitor the participants' lifestyle.

Who is the study for?
This trial is for adults over 18 with a BMI ≤ 40 who have been diagnosed with early-stage breast, endometrial, or prostate cancer and are scheduled for surgery. They should not be doing more than minimal structured exercise weekly and must be willing to follow study procedures including at-home exercise and lifestyle monitoring.Check my eligibility
What is being tested?
The study tests different levels of pre-surgical aerobic exercise (treadmill walking) on patients with solid tumors. It aims to determine the safest exercise dose and its effects on patient health and cancer outcomes using apps and devices for continuous monitoring.See study design
What are the potential side effects?
Since this trial involves aerobic exercises like treadmill walking, potential side effects may include typical physical activity-related issues such as muscle soreness, fatigue, joint pain, or exacerbation of existing health problems.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have surgery scheduled for my solid tumor at least 2 weeks after joining the study.
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I have prostate cancer that has not been treated yet, but I am scheduled for surgery.
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I am older than 18 years.
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I have been diagnosed with endometrial, breast, or prostate cancer.
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I am older than 18 years.
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I had a lung biopsy within the last 14 days.
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I have a solid tumor and my surgery is scheduled at least 2 weeks after joining the study.
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I am considering a trial that is testing the safety of new doses.
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My trial is in the very early stages, testing if the treatment could work.
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I have early-stage breast cancer and finished a study with IRB# 15-147.
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I have enough lung tissue samples from my biopsy for advanced testing.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
identify the recommended dose of aerobic training

Trial Design

2Treatment groups
Experimental Treatment
Group I: Pilot "Proof-of-Concept"Experimental Treatment1 Intervention
Individualized, progressive aerobic training consisting of treadmill walking for a total of 150 mins/wk delivered over 5 sessions/wk following a linear (breast, prostate, and endometrial) or non-linear (lung) dosing schedule for a minimum of 2 weeks.
Group II: Phase 1a: Dose-Finding / EscalationExperimental Treatment1 Intervention
Individualized, progressive aerobic training consisting of treadmill walking ranging from a total of 90 mins/wk to 450 mins/wk delivered over 3 to 7 sessions/wk following a linear or non-linear dosing schedule for a minimum of 2 weeks. If a patient is temporarily unable to complete supervised sessions as a result of unforeseen circumstances, patients may be assigned low intensity unsupervised training sessions per EP/PI discretion.

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor
1,928 Previous Clinical Trials
591,738 Total Patients Enrolled
Lee W. Jones, PhDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center

Media Library

Treadmill Walking Clinical Trial Eligibility Overview. Trial Name: NCT03813615 — Phase < 1
Solid Tumors Research Study Groups: Pilot "Proof-of-Concept", Phase 1a: Dose-Finding / Escalation
Solid Tumors Clinical Trial 2023: Treadmill Walking Highlights & Side Effects. Trial Name: NCT03813615 — Phase < 1
Treadmill Walking 2023 Treatment Timeline for Medical Study. Trial Name: NCT03813615 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are being recruited for this experiment?

"Confirmed. Clinicaltrials.gov has the latest information on this clinical trial, which was first posted in January 2021 and most recently updated April 2022. 84 participants are required from 8 different sites for its successful completion."

Answered by AI

Are there still opportunities for participants to enroll in this clinical trial?

"According to the clinicaltrials.gov portal, this medical research is actively recruiting participants, with postings dated January 21st 2019 and revisions made on April 15th 2022."

Answered by AI

How many facilities is this experiment being supervised in?

"This clinical trial is currently being administered at 8 different facilities, such as Memorial Sloan Kettering Nassau (Limited Protocol Activities) in Uniondale, Memorial Sloan Kettering Bergen (Limited Protocol Activities) in Montvale, and Memorial Sloan Kettering Commack (Limited Protocol Activities) in Commack. Additionally there are 5 other medical sites hosting the study."

Answered by AI
~8 spots leftby Jan 2025