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Pain Control Methods for Postoperative Esophagectomy Pain

Phase 1 & 2
Recruiting
Led By Brian Louie, M.D.
Research Sponsored by Swedish Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
All adult individuals who undergo an esophagectomy with an intended minimally invasive approach of the chest at Swedish Medical Center-First Hill. These approaches include: 3-hole with R video-assisted thoracoscopic surgery (VATS), Ivor Lewis R VATS
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (prior to or) to every 12 hours postoperatively thru post operative day 4.
Awards & highlights

Study Summary

This trial tests how well 3 treatments reduce pain after an esophageal surgery.

Who is the study for?
This trial is for adults who are having a minimally invasive esophagectomy at Swedish Medical Center-First Hill. Candidates should be undergoing specific surgical approaches and must be able to consent. It's not for those under 18, on daily narcotics for chronic pain, with past thoracic surgery, non-English speakers, or with conditions that rule out epidural anesthesia.Check my eligibility
What is being tested?
The study compares different pain control methods after minimally invasive esophagectomies: intercostal nerve blocks alone, cryo-ablation plus nerve blocks, and serratus plane catheter plus nerve blocks. Patients will be randomly assigned to one of these treatment groups.See study design
What are the potential side effects?
Potential side effects may include discomfort at the block site, infection risk from catheters or injections used in the procedures, possible allergic reactions to anesthetics used during the blocks, and varying degrees of pain relief effectiveness.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am having a minimally invasive esophagectomy at Swedish Medical Center-First Hill.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (prior to or) to every 12 hours postoperatively thru post operative day 4.
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (prior to or) to every 12 hours postoperatively thru post operative day 4. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Post Operative Pain
Post Operative Pain Change Over Time
Post Operative Pain Day 1 (AM)
+7 more

Trial Design

3Treatment groups
Active Control
Group I: local intercostal nerve blockActive Control2 Interventions
Patients receiving intercostal blocks will receive a total of 1.0 cc/kg of 0.25% Bupivacaine + epinephrine. This will be divided into two-thirds allocated for use in the chest/intercostal block and one-third allocated for use in the abdomen.
Group II: cryo-ablation plus intercostal nerve blockActive Control2 Interventions
Patients receiving cryo-analgesia and intercostal blocks, the patient will receive cryo-ablation prior to the intercostal block. The cryo-ablation will occur 2 cm from the sympathetic chain 2 intercostal spaces above and 2 intercostal spaces below the access incision. The patient will also receive a total of 1.0 cc/kg of 0.25% Bupivacaine + epinephrine. This will be divided into two-thirds allocated for use in the chest/intercostal block and one-third allocated for use in the abdomen.
Group III: serratus plane catheter plus intercostal nerve blockActive Control2 Interventions
Patients receiving serratus plane catheter blocks and intercostal nerve blocks, a total of 1.0 cc/kg of 0.25% Bupivacaine + epinephrine will be administered. A total of 20 cc of the weight-based calculation will be reserved for the serratus plane catheter. The remaining local anesthetic will be divided into two-thirds for the chest and one-third for the abdomen. Patients with serratus plane catheters will have an ongoing infusion of 0.2% ropivacaine at 8 ml per hour. The serratus plane catheters will also receive a bolus of 20 ml of 0.25% bupivacaine with epinephrine on Post Operative Day (POD) #1, 2, 3, 4, and 5 by the pain service.

Find a Location

Who is running the clinical trial?

Swedish Medical CenterLead Sponsor
53 Previous Clinical Trials
8,264 Total Patients Enrolled
Brian Louie, M.D.Principal InvestigatorSwedish Cancer Institute

Media Library

local intercostal nerve block Clinical Trial Eligibility Overview. Trial Name: NCT05906134 — Phase 1 & 2
Postoperative Complications Research Study Groups: local intercostal nerve block, cryo-ablation plus intercostal nerve block, serratus plane catheter plus intercostal nerve block
Postoperative Complications Clinical Trial 2023: local intercostal nerve block Highlights & Side Effects. Trial Name: NCT05906134 — Phase 1 & 2
local intercostal nerve block 2023 Treatment Timeline for Medical Study. Trial Name: NCT05906134 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies for participants in this research study?

"Clinicaltrials.gov has recently been updated to show that this study is now recruiting participants; it was posted on April 26th 2022 and last amended on June 7th 2023."

Answered by AI

How many participants have joined this experiment thus far?

"Affirmative. The clinicaltrial.gov database suggests that this medical research is actively recruiting participants, with the original posting date being on April 26th 2022 and a recent edit taking place on June 7th 2023. This trial needs to recruit 30 patients from one site for successful completion."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Minimally Invasive Esophagectomy Pain Control Trial
2022. "Minimally Invasive Esophagectomy Pain Control Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05906134.
All > Acute Pain
~9 spots leftby Apr 2025
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