← Back to Search

Suture Techniques for Preventing Incisional Hernia After Liver Surgery

Phase 2

Recruiting

Led By Timothy E Newhook

Research Sponsored by M.D. Anderson Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Elective surgery

Planned midline laparotomy incision or inverted-L incision

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 30 days after surgery

Awards & highlights

Study Summary

This trial compares two different kinds of surgical closing techniques for patients having liver tumor surgery. One technique may help lower the chances of developing a hole in the wall of the abdomen at the incision site.

Who is the study for?

This trial is for adults over 18 who are scheduled for elective liver tumor surgery (hepatectomy) due to cancer, between May 2021 and November 2024. They must be planning to have a specific type of incision made. Pregnant women, those with prior mesh placement from past surgeries, or pre-existing abdominal hernias cannot participate.Check my eligibility

What is being tested?

The study is testing two surgical techniques used to close the incision after liver surgery: short stitch suture versus traditional suture. The goal is to determine which method better prevents an incisional hernia—a bulge through the site where the skin was cut.See study design

What are the potential side effects?

While not drug-related, side effects may include discomfort at the incision site, risk of infection, potential complications leading to hernia with either technique, and varying recovery times based on individual healing processes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am planning to have elective surgery.

Select...

I am scheduled for surgery with a specific type of incision.

Select...

I am 18 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 30 days after surgery

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 30 days after surgery

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 30 days after surgery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Radiographic incidence rate of incisional hernia

Secondary outcome measures

Any readmission related to hernia repair

Health-related quality of life assessment

Incidence of adverse events (AEs)

+7 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Arm I (hepatectomy using small bites fascial closure)Experimental Treatment2 Interventions

Patients undergo hepatectomy as planned using small bites fascial method for abdominal wall closure.

Group II: Arm II (hepatectomy using conventional fascial method)Active Control2 Interventions

Patients undergo hepatectomy as planned using conventional fascial method for abdominal wall closure.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Surgical Procedure

2020

Completed Phase 2

~160

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor

2,973 Previous Clinical Trials

1,789,206 Total Patients Enrolled

22 Trials studying Liver Cancer

9,411 Patients Enrolled for Liver Cancer

Timothy E NewhookPrincipal InvestigatorM.D. Anderson Cancer Center

Timothy E Newhook, MDPrincipal InvestigatorM.D. Anderson Cancer Center

Media Library

Short Stitch Suture Clinical Trial Eligibility Overview. Trial Name: NCT04982653 — Phase 2

Liver Cancer Research Study Groups: Arm I (hepatectomy using small bites fascial closure), Arm II (hepatectomy using conventional fascial method)

Liver Cancer Clinical Trial 2023: Short Stitch Suture Highlights & Side Effects. Trial Name: NCT04982653 — Phase 2

Short Stitch Suture 2023 Treatment Timeline for Medical Study. Trial Name: NCT04982653 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has this type of operation been cleared by the FDA?

"Surgical Procedure has been studied in Phase 3 trials, which means that there is some evidence of its efficacy and that it has undergone multiple rounds of safety testing. Our team rates its safety as a 3."

Answered by AI

How many individuals are being medicated as part of this research project?

"That is correct, the information on clinicaltrials.gov reveals that this study needs participants. The trial was originally posted on 1/4/2022 and was most recently edited on 7/26/2022. The trial is recruiting for 140 participants across 1 sites."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Short Stitch Versus Traditional Suture for the Prevention of Incisional Hernia After Open Hepatectomy

2022. "Short Stitch Versus Traditional Suture for the Prevention of Incisional Hernia After Open Hepatectomy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04982653.

All > Bile Duct Cancer > Hernia