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Procedure

Healthy Volunteers for Healthy Subjects (CAMERA Trial)

N/A

Recruiting

Led By Barry Borlaug, MD

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Apparently healthy volunteers free of symptoms of exertional breathlessness or fatigue and any diagnosis of heart failure

Patients with left ventricular ejection fraction (EF) ≥ 50%

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline

Awards & highlights

CAMERA Trial Summary

This trial aims to study the pressure in the blood vessels of the lungs and other related measurements in healthy people of different ages, both at rest and during exercise.

Who is the study for?

The CAMERA study is for healthy adults who want to help understand heart and blood vessel function. Participants should be willing to undergo various tests like heart catheterization, MRI, and DEXA scans.Check my eligibility

What is being tested?

This study is testing how well the heart and blood vessels work in healthy people of different ages by measuring pressures inside the heart at rest and during exercise using specialized procedures.See study design

What are the potential side effects?

Possible side effects include discomfort or bruising from catheter insertion for the right heart catheterization, reactions to contrast material used in MRI, and minimal exposure to radiation during DEXA scan.

CAMERA Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am healthy, without symptoms like shortness of breath or tiredness from exercise, and I don't have heart failure.

Select...

My heart pumps blood well, with an EF of 50% or higher.

Select...

I have never had heart failure.

CAMERA Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Pulmonary Capillary Wedge Pressure (PCWP) at rest

Pulmonary Capillary Wedge Pressure (PCWP) during exercise

Secondary outcome measures

Blood free fatty acids (FFA) level

Blood glucose level

Blood insulin level

+17 more

CAMERA Trial Design

1Treatment groups

Experimental Treatment

Group I: Healthy VolunteersExperimental Treatment3 Interventions

Healthy volunteers with no history of Heart Failure (HF) will undergo a Right Heart Catheterization with Hemodynamics and Limited Echocardiogram, MRI, and DEXA scan.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Magnetic Resonance Imaging (MRI)

2015

Completed Phase 4

~1800

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor

3,216 Previous Clinical Trials

3,767,408 Total Patients Enrolled

Barry Borlaug, MDPrincipal InvestigatorMayo Clinic

9 Previous Clinical Trials

1,379 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the primary objectives of this clinical trial?

"The primary objective of this study is to evaluate the Pulmonary Capillary Wedge Pressure (PCWP) at rest. Secondary outcomes include measuring Trans-cardiac uptake of glucose during exercise by analyzing arterial and coronary sinus blood samples collected during the cardiac catheterization procedure. Additionally, Body fat mass will be assessed using dual X-ray absorptiometry (DEXA), and Total blood volume will be evaluated through the radiolabeled iodinated albumin (131I, 5-25 μCu) indicator dilution technique utilizing the BVA-100 Blood Volume Analyzer provided by Daxor Corp in New york."

Answered by AI

Are there any ongoing efforts to enroll participants for this study at the moment?

"According to the information available on clinicaltrials.gov, this particular trial is not currently seeking participants. The initial posting of the study was made on January 1st, 2024, and it was last edited on January 12th, 2024. However, there are a total of 769 other trials actively accepting patients at this time."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study

Barry Borlaug 2024. "CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06220396.

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