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Pulsatile insulin at 40mU/m2/min for Insulin Sensitivity

N/A

Recruiting

Led By Candida Rebello, PhD

Research Sponsored by Pennington Biomedical Research Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24 hours

Awards & highlights

Study Summary

This trial will compare two methods of measuring insulin sensitivity. Insulin is a hormone that helps control blood sugar levels. The current standard method involves continuously infusing insulin, while the new method involves infusing

Who is the study for?

This trial is for individuals who have completed the Motivate Study (NCT05649176) and are interested in further examining insulin resistance and sensitivity. Participants must have finished the end-of-study hyperinsulinemic euglycemic clamp test from the Motivate study to be eligible.Check my eligibility

What is being tested?

The study investigates how different methods of insulin administration affect insulin action. It compares continuous infusion with pulsatile infusion, where insulin is given every five minutes, during a hyperinsulinemic euglycemic clamp test—a procedure that measures how sensitive the body is to insulin.See study design

What are the potential side effects?

While specific side effects are not listed, typical risks may include reactions at the infusion site, low blood sugar levels due to increased insulin sensitivity, or discomfort associated with the clamp procedure.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ one day

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~one day

This trial's timeline: 3 weeks for screening, Varies for treatment, and one day for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Insulin sensitivity

Secondary outcome measures

Insulin resistance

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Pulsatile insulin at 40mU/m2/minExperimental Treatment1 Intervention

Participants will receive insulin infused every five minutes during the hyperinsulinemic euglycemic clamp test of insulin sensitivity

Group II: Continuous insulin at 40mU/m2/minActive Control1 Intervention

Paricipants will receive insulin infused continuously during the hyperinsulinemic euglycemic clamp test of insulin sensitivity.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Pennington Biomedical Research CenterLead Sponsor

305 Previous Clinical Trials

182,024 Total Patients Enrolled

6 Trials studying Insulin Sensitivity

126 Patients Enrolled for Insulin Sensitivity

Candida Rebello, PhDPrincipal InvestigatorPennington Biomedical Research Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Which individuals are eligible to participate in this clinical study?

"To qualify for participation in this clinical trial, prospective participants must exhibit insulin sensitivity and fall within the age range of 50 to 75. The study aims to recruit approximately 12 eligible individuals."

Answered by AI

Is this medical study open to enrolling individuals who are 65 years of age or older?

"To be eligible for participation in this trial, patients must fall within the age range of 50 to 75. It's worth noting that there are a total of 19 studies available for individuals below the age of 18 and 93 studies catering specifically to patients aged over 65."

Answered by AI

Is this medical study currently open for enrollment?

"As per the information found on clinicaltrials.gov, this particular study is not actively seeking participants. The trial was initially posted on January 1st, 2024 and its most recent update occurred on January 11th, 2024. Nonetheless, there are currently 153 other ongoing clinical trials that are accepting patients at this time."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effect of Pulsatile Hormone Administration on Insulin Action

Candida Rebello 2024. "Effect of Pulsatile Hormone Administration on Insulin Action". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06216665.

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