Embryo Transfer Timing for Infertility
(PRECiSE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Infertility affects more than 6 million women the United States and is a major life event that results in a wide range of socio-cultural, emotional, physical and financial problems. The most successful treatment for infertility, in-vitro fertilization (IVF), fertilizes a woman's eggs with her partner's sperm in a culture dish and transfers the resulting embryos into the uterus. Most of the time, prior to being transferred, embryos are grown in the dish for 5-7 days after which some of them reach an advanced stage (blastocyst stage). This has several advantages such as a lower chance of a multiple pregnancies (twins, triplets etc.) after transfer and fewer transfer procedures. However, it is possible that embryos would survive better if transferred into the uterus at the 8-cell stage after growing them for only 3 days. Thus, when patients only have a small number of embryos they and their physicians face the difficult choice when to transfer because there are currently no studies available to guide this decision.
This randomized controlled trial is comparing pregnancy outcomes and patient satisfaction of poor prognosis patients with 5 or fewer embryos undergoing either transfer of an advanced (blastocyst) or an 8-cell embryo.
This study will provide the data for the development of guidelines for IVF providers to make evidence-based decisions when to transfer embryos in poor prognosis IVF patients, reduce patients' anxiety regarding cycle cancellation and improve patient counseling, which will increase patients' ability to participate in the development of their treatment plan.
Who Is on the Research Team?
Werner Neuhausser, MD PhD
Principal Investigator
Beth Israel Deaconess Medical Center/Harvard Medical School
Dustin Rabideau, PhD
Principal Investigator
Massachusetts General Hospital
Are You a Good Fit for This Trial?
This trial is for women undergoing their first IVF cycle with 5 or fewer fertilized eggs (zygotes) on the first day of development, who are planning to have a fresh embryo transfer. It's not specified who can't join because the exclusion criteria are missing.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo embryo transfer on either day 3 (cleavage-stage) or day 5-7 (blastocyst-stage) of embryo development
Follow-up
Participants are monitored for pregnancy outcomes and safety for 6 months after embryo transfer
Extended Follow-up
Participants are monitored for pregnancy outcomes until delivery if pregnancy is achieved
What Are the Treatments Tested in This Trial?
Interventions
- Embryo Transfer
Find a Clinic Near You
Who Is Running the Clinical Trial?
Beth Israel Deaconess Medical Center
Lead Sponsor
Yale University
Collaborator
University of Michigan
Collaborator
Brigham and Women's Hospital
Collaborator
Columbia University
Collaborator
Patient-Centered Outcomes Research Institute
Collaborator
Massachusetts General Hospital (MGH)
Collaborator
Yale School of Medicine
Collaborator
University of Pennsylvania
Collaborator
Boston IVF
Collaborator