TMS for Cerebellar Ataxia
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether a type of non-invasive brain stimulation, called TMS (transcranial magnetic stimulation), can help individuals with cerebellar ataxia, a condition affecting movement and balance. Researchers aim to determine if this treatment can enhance motor learning, which involves learning and performing new movements. Participants will undergo various TMS sessions and a sham session to assess their impact on motor task learning. Individuals diagnosed with cerebellar ataxia due to cerebellar degeneration, who have normal vision and hearing, are well-suited for this trial. As an unphased trial, this study offers a chance to contribute to groundbreaking research that could lead to new treatment options for cerebellar ataxia.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that TMS is safe for individuals with cerebellar ataxia?
Research has shown that repetitive transcranial magnetic stimulation (rTMS) is a safe and noninvasive brain treatment. Studies indicate it can help with brain conditions like Parkinson's and Alzheimer's. It may also improve movement problems in people with cerebellar ataxia, a disorder affecting coordination.
In clinical trials, patients with cerebellar ataxia who received rTMS experienced noticeable improvements, suggesting the treatment is well-tolerated. These studies did not report any severe side effects, which is encouraging.
Overall, rTMS has been tested in many settings and is considered safe. While more research is ongoing, current evidence supports its safety.12345Why are researchers excited about this trial?
Researchers are excited about the use of repetitive transcranial magnetic stimulation (rTMS) for cerebellar ataxia because it offers a non-invasive approach that directly targets brain activity, which is different from traditional medications. While most treatments for cerebellar ataxia focus on managing symptoms through drugs or physical therapy, rTMS uses magnetic fields to stimulate specific areas of the brain, potentially improving motor learning and coordination. This technique, particularly the theta burst stimulation (TBS) variant, could provide faster and more targeted improvements in motor function, offering new hope where current therapies have limitations.
What evidence suggests that TMS is effective for cerebellar ataxia?
Research has shown that repetitive transcranial magnetic stimulation (rTMS) can greatly improve symptoms in people with cerebellar ataxia. Studies have found that rTMS, a non-invasive method using magnetic fields to stimulate the brain, can have lasting positive effects on various neurological conditions, including ataxia. In this trial, participants will receive different forms of rTMS—continuous TBS, intermittent TBS, or sham TBS—to study its effect on motor learning behavior. While the level of improvement can differ, rTMS is generally considered a safe and promising way to reduce ataxia symptoms.15678
Who Is on the Research Team?
Amanda S Therrien, PhD
Principal Investigator
Moss Rehabilitation Research Institute
Are You a Good Fit for This Trial?
This trial is for individuals with cerebellar ataxia due to cerebellar degeneration. Participants must have normal or corrected vision and hearing, and meet safety criteria for transcranial magnetic stimulation (TMS). They cannot join if they have drug abuse history, sensory loss in arms, cognitive issues affecting testing or consent, or arm injuries causing pain.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
TMS is used to assess baseline recruitment curves for corticomotor excitability and short-interval intracortical inhibition, and the cortical silent period. Participants complete a standardized clinical rating of their ataxia severity and a behavioral task using the RL paradigm.
Intervention
Participants receive cTBS, iTBS, or sham stimulation to modulate intracortical inhibition in M1 prior to performing the RL task. This phase includes 3 sessions of the RL task.
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- TMS
TMS is already approved in United States, European Union, Canada for the following indications:
- Depression
- Anxiety disorders
- Post-traumatic stress disorder (PTSD)
- Obsessive-compulsive disorder (OCD)
- Depression
- Anxiety disorders
- Post-traumatic stress disorder (PTSD)
- Obsessive-compulsive disorder (OCD)
- Depression
- Anxiety disorders
- Post-traumatic stress disorder (PTSD)
- Obsessive-compulsive disorder (OCD)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Albert Einstein Healthcare Network
Lead Sponsor
Medical University of South Carolina
Collaborator