This trial is evaluating whether Perampanel Tablet will improve 1 primary outcome and 32 secondary outcomes in patients with Aura. Measurement will happen over the course of Treatment Period of Core Study and Extension Phase A: Week 0 to Week 56.
This trial requires 100 total participants across 1 different treatment group
This trial involves a single treatment. Perampanel Tablet is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"There is a significant amount of literature documenting the use of EEG as a standard method of diagnosing epilepsies. However, many of these studies focus only on focal brain pathology. As epileptic seizures are the most common form of seizure phenomenology, there is always a significant possibility that EEGs in epilepsy patients may show focal alterations in EEG readings. The most common of these is focal slowing, which is associated with frontal and temporal cortical areas. The presence of this phenomenon has been reported in the majority of studies of patients with focal epilepsies. Further research is required, but if it is confirmed, the EEG should be considered an important means of further identifying this condition." - Anonymous Online Contributor
"The incidence of familial epilepsies is still rising and thus the incidence of familial epilepsies is likely to continue increasing, which indicates that the frequency of these diseases is increasing over time." - Anonymous Online Contributor
"Variants in the SCN1A gene are related to both infantile-onset spasms and familial partial epilepsy. In our patient family, we have confirmed the mutation as a potential cause of epilepsy in four unrelated members of the same family. In the light of these and previous findings, it is hypothesized that SCN1A deficiency may lead to epilepsy. The pathophysiology of this disease should be further studied." - Anonymous Online Contributor
"As the prevalence of epilepsy is increasing in the older generations of the society, the development of a proper therapeutic approach in this group could be a major priority for both neurologists and general practitioners." - Anonymous Online Contributor
"There is some evidence that familial epilepsies are curable, with seizure control in many cases by the age of three to five years. In addition, surgical treatment may be effective in a minority of cases. More prospective studies of this intriguing hypothesis are needed." - Anonymous Online Contributor
"There are hundreds of different family histories of familial epilepsies. The occurrence of epilepsy is variable, but atypical in many of the families. Epilepsies may occur singly within families or in addition to other neurological problems." - Anonymous Online Contributor
"There have been no definitive breakthrough for the existing clinical therapies for familial epilepsies. While more studies have to be done, it appears hard to find an effective solution for these diseases." - Anonymous Online Contributor
"Perampanel tablets significantly improved all aspects of QOL of those with FES compared to placebo across a range of measures. Data from a recent study suggest that more long-term prospective controlled randomized studies investigating QOL outcomes are warranted, and that further studies should explore dosage considerations for higher seizure-free rates." - Anonymous Online Contributor
"Perampanel is a first-line treatment for the treatment of partial epilepsy. It works best in patients with temporal lobe-related epilepsy. In patients with juvenile myoclonic epilepsy, it reduces seizures in half of the patients. We believe the evidence in this article shows the benefits of perampanel tablet." - Anonymous Online Contributor
"The common side effects of perampanel in Chinese patients are headache, dizziness, fatigue and drowsiness without insomnia, nausea and constipation. The side effects of perampanel can be greatly improved by adjusting the dosing schedule of the drug according to the individual condition." - Anonymous Online Contributor
"The familial occurrence of epilepsy in our study family is consistent with reports in the medical literature, and may be related to a novel gene on chromosome 6q24-q27." - Anonymous Online Contributor
"The causes of familial epilepsy differ from sporadic, non-symptomatic epilepsy. Furthermore, even among those affected by some symptom, the underlying etiology can still be elusive. For this reason, multiple genetic and environmental factors may influence the etiology of familial epilepsy, and the identification of these factors remains difficult." - Anonymous Online Contributor