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Non-invasive Brain Stimulation

TMS for Drug Addiction

N/A
Recruiting
Led By Yihong Yang, Ph.D.
Research Sponsored by National Institute on Drug Abuse (NIDA)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Subjects must be 18 - 60 years of age
Be 18 - 60 years of age.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up tms visits
Awards & highlights

Study Summary

This trial is testing transcranial magnetic stimulation (TMS) as a potential treatment for drug addiction. TMS is a non-invasive brain stimulation that is approved to treat depression. This trial is testing to see how TMS affects the brain when it stimulates an area in the front of the brain. The trial will last 3-6 hours and will include TMS-MRI sessions and questionnaires.

Who is the study for?
This trial is for healthy, right-handed adults aged 18-60 who don't use drugs. Participants must not have a history of neurological disorders, heart conditions, metal implants in the head, or severe hearing loss. Pregnant women and those not using contraception are excluded.Check my eligibility
What is being tested?
The study tests how Transcranial Magnetic Stimulation (TMS) affects brain activity. It involves placing a coil on the head to stimulate the brain with magnetic pulses while undergoing MRI scans to observe changes.See study design
What are the potential side effects?
TMS may cause discomfort at the stimulation site, headache, lightheadedness or seizures in rare cases. The MRI process is generally safe but can be uncomfortable due to loud noises and confined space.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 60 years old.
Select...
I am between 18 and 60 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~tms visits
This trial's timeline: 3 weeks for screening, Varies for treatment, and tms visits for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
effects of TMS on fMRI blood oxygen level-dependent (BOLD) responses, TMS induced changes on resting state functional connectivity, and their associations with relevant structural connectivity revealed by DTI.

Trial Design

1Treatment groups
Experimental Treatment
Group I: TMSExperimental Treatment1 Intervention
All participants will receive TMS to investigate acute modulations of brain activity by TMS

Find a Location

Who is running the clinical trial?

National Institute on Drug Abuse (NIDA)Lead Sponsor
2,468 Previous Clinical Trials
2,619,278 Total Patients Enrolled
Yihong Yang, Ph.D.Principal InvestigatorNational Institute on Drug Abuse (NIDA)
2 Previous Clinical Trials
905 Total Patients Enrolled

Media Library

TMS (Non-invasive Brain Stimulation) Clinical Trial Eligibility Overview. Trial Name: NCT03394066 — N/A
Healthy Subjects Research Study Groups: TMS
Healthy Subjects Clinical Trial 2023: TMS Highlights & Side Effects. Trial Name: NCT03394066 — N/A
TMS (Non-invasive Brain Stimulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03394066 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How might I join this experiment?

"70 individuals are being admitted to this clinical trial, all of whom must be between 18-60 years old and in good health. Prospective participants will need to provide valid informed consent along with government issued forms of identification for age verification. Additionally, the Edinburgh Handedness Inventory used as a screening tool helps ensure that only right-handed people participate due to its potential effect on MRI data variability. As part of their medical assessment applicants must also undertake Vital Signs tests, EKG's, HIV screenings (salivary & serum), body measurements such as height/weight and laboratory tests which include CBCs, metabolic profiles and TSH levels"

Answered by AI

Does this experimental trial accept participants who are younger than sixty years of age?

"As per the inclusion criteria, only those aged 18 to 60 may participate in this clinical trial. Alternatively, there are 50 trials specifically for minors and 372 studies that cater to patients over 65 years of age."

Answered by AI

Does this research program have open enrollment for participants?

"Affirmative. Information published on clinicaltrials.gov indicates that the trial is actively recruiting volunteers, having been first posted on September 19th 2018 and most recently updated on December 1st 2022 with a goal of enrolling 70 individuals at one site."

Answered by AI

How many participants are currently involved in this clinical investigation?

"Affirmative. The trial's particulars on clinicaltrials.gov establishes that it is presently recruiting participants, which began in September 2018 with the last update posted on December 1st 2022. This medical experiment requires 70 patients to be enrolled at one site."

Answered by AI

Who else is applying?

What state do they live in?
Pennsylvania
Maryland
How old are they?
18 - 65
What site did they apply to?
National Institute on Drug Abuse
What portion of applicants met pre-screening criteria?
Met criteria

How responsive is this trial?

Typically responds via
Email
Most responsive sites:
  1. National Institute on Drug Abuse: < 48 hours
Average response time
  • < 2 Days
Recent research and studies
Neuromodulation: Technology at the Neural InterfaceJournal
High-frequency Transcranial Magnetic Stimulation Combined with Functional Magnetic Resonance Imaging Reveals Distinct Activation Patterns Associated with Different Dorsolateral Prefrontal Cortex Stimulation Sites
Caparelli, Elisabeth C., Brooke Schleyer, Tianye Zhai, Hong Gu, Osama A. Abulseoud, and Yihong Yang. 2022. “High-frequency Transcranial Magnetic Stimulation Combined with Functional Magnetic Resonance Imaging Reveals Distinct Activation Patterns Associated with Different Dorsolateral Prefrontal Cortex Stimulation Sites”. Neuromodulation: Technology at the Neural Interface. Elsevier BV. doi:10.1016/j.neurom.2022.03.002.
Neuromodulation: Technology at the Neural InterfaceJournal
High-frequency Transcranial Magnetic Stimulation Combined with Functional Magnetic Resonance Imaging Reveals Distinct Activation Patterns Associated with Different Dorsolateral Prefrontal Cortex Stimulation Sites
Caparelli, Elisabeth C., Brooke Schleyer, Tianye Zhai, Hong Gu, Osama A. Abulseoud, and Yihong Yang. 2022. “High-frequency Transcranial Magnetic Stimulation Combined with Functional Magnetic Resonance Imaging Reveals Distinct Activation Patterns Associated with Different Dorsolateral Prefrontal Cortex Stimulation Sites”. Neuromodulation: Technology at the Neural Interface. Elsevier BV. doi:10.1016/j.neurom.2022.03.002.
clinicaltrials.govStudy
Mechanism of Non-invasive Magnetic Stimulation
2018. "Mechanism of Non-invasive Magnetic Stimulation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03394066.
~7 spots leftby Dec 2024
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