← Back to Search

Procedure

Real Repetitive transcranial magnetic stimulation for Substance Use Disorder

N/A
Waitlist Available
Research Sponsored by Oregon Health and Science University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Subjects must have a minimum 4-week period of detoxification and a desire to stop using methamphetamine.
Subjects must use at least 0.5 g per day at least 5 days per week and have a minimum 12-month history of METH abuse.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 months
Awards & highlights

Study Summary

This trial is investigating if high-frequency repetitive transmagnetic stimulation (HF-rTMS) can help to reduce cue-induced craving for methamphetamine in adults with methamphetamine use disorder (MUD). The participants will be randomly assigned to receive either real or sham rTMS, and will be shown either methamphetamine or neutral cues before each session.

Eligible Conditions
  • Substance Use Disorder
  • Stimulant Addiction
  • Methamphetamine Addiction
  • Stimulant Abuse
  • Transcranial Magnetic Stimulation
  • Methamphetamine Abuse

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
People must meet four criteria in order to be considered for the study: they must have detoxified for at least four weeks, have a desire to stop using methamphetamine, not be pregnant, and not be taking medications that would interfere with the study.
Select...
To be eligible for this study, subjects must use METH at least 0.5 g per day, at least 5 days per week, and have a minimum 12-month history of METH abuse.
Select...
You must have been using at least half a gram of methamphetamine per day, for at least 5 days a week, for the past year.
Select...
You have been diagnosed with a methamphetamine addiction according to the DSM V guidelines.
Select...
You need to have stopped using methamphetamine for at least 4 weeks and have a strong desire to quit using it.
Select...
People who use methamphetamine must meet the criteria for a diagnosis of methamphetamine use disorder according to the DSM V.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Effect of rTMS directed at left DLPFC on craving for methamphetamine as assessed by a Visual Analog Scale (VAS).
Effect of rTMS directed at left DLPFC on craving for methamphetamine as assessed by the Severity of Dependence Scale.
Effect of rTMS directed at left DLPFC on craving for methamphetamine as assessed by the Stimulant Craving Questionnaire (STCQ).
Secondary outcome measures
Methamphetamine
Methamphetamine

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Treatment rTMS + meth picturesExperimental Treatment2 Interventions
Participants in this group will receive real repetitive transcranial magnetic stimulation treatments. Before each rTMS session they will be exposed to a series of methamphetamine-related pictures to evaluate response to methamphetamine visual cues while receiving real rTMS treatments. This group will be referred to as real METH (RM).
Group II: Treatment rTMS + neutral picturesActive Control2 Interventions
Participants in this group will receive real repetitive transcranial magnetic stimulation treatments. Before each rTMS session they will be exposed to a series of neutral pictures to evaluate response to neutral visual cues while receiving real rTMS treatments. This group will be referred to as real neutral (RN).
Group III: Sham rTMS + meth picturesPlacebo Group2 Interventions
Participants in this group will receive sham repetitive transcranial magnetic stimulation treatments. Before each rTMS session they will be exposed to a series of methamphetamine-related pictures to evaluate response to methamphetamine visual cues while receiving sham rTMS treatments. This group will be referred to as sham METH (SM).
Group IV: Sham rTMS + neutral picturesPlacebo Group2 Interventions
Participants in this group will receive sham repetitive transcranial magnetic stimulation treatments. Before each rTMS session they will be exposed to a series of neutral pictures to evaluate response to neutral visual cues while receiving sham rTMS treatments. This group will be referred to as sham neutral (SN).

Find a Location

Who is running the clinical trial?

Oregon Health and Science UniversityLead Sponsor
966 Previous Clinical Trials
6,845,701 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are geriatric patients being considered for this trial?

"This clinical trial has a minimum age of 18 and maximum age of 65 in order to qualify for inclusion."

Answered by AI

Who qualifies to take part in this experiment?

"To be considered for this medical trial, individuals must possess transcranial magnetic stimulation (tms) and fit within the 18-65 year old age bracket. The research team is currently looking to recruit approximately 50 people."

Answered by AI

What is the cap on how many participants may join this research endeavor?

"Affirmative. Clinicaltrials.gov indicates that this research is currently recruiting patients, commencing from February 7th 2018 and the most recent update being September 16 2021. At present, 50 participants are needed to be recruited at 1 designated site."

Answered by AI

Has recruitment for this experiment commenced?

"Affirmative. Data hosted on clinicaltrials.gov certifies that this research project, first announced on February 7th 2018, is currently recruiting individuals to partake in it. Approximately 50 persons will be accepted into the study at one facility."

Answered by AI

Who else is applying?

What state do they live in?
Oregon
Texas
California
How old are they?
18 - 65
What site did they apply to?
Veterans Affairs Portland Health Care System
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
~7 spots leftby Mar 2025