TMS for Cocaine Use Disorder
Trial Summary
What is the purpose of this trial?
The purpose of this study is to assess effects of intermittent theta burst stimulation (iTBS) to left dorsolateral prefrontal cortex (dlPFC) and dorsomedial prefrontal cortex (dmPFC) compared to sham on electrophysiological indices of reward sensitivity and motivated attention in adults with cocaine use disorder.
Do I need to stop taking my current medications for the trial?
The trial requires participants to stop taking certain medications that increase the risk of seizures, such as clozapine, chlorpromazine, bupropion, and others, during the study. If you are on any of these medications, you will need to stop taking them to participate.
What data supports the effectiveness of this treatment for cocaine use disorder?
Research shows that intermittent theta burst stimulation (iTBS), a type of transcranial magnetic stimulation (TMS), can reduce cocaine use and cravings in people with cocaine use disorder. Studies have found that iTBS is as effective as traditional TMS methods but is quicker and more tolerable, making it a promising treatment option.12345
Is TMS safe for treating cocaine use disorder?
TMS, including iTBS, is generally considered safe and well-tolerated, with some participants experiencing mild side effects like headaches. In studies with cocaine users, most participants tolerated the treatment well, although one person experienced a temporary neurological event and cocaine-induced psychosis after stopping treatment.12346
How does the TMS treatment for cocaine use disorder differ from other treatments?
The TMS treatment for cocaine use disorder is unique because it uses intermittent theta burst stimulation (iTBS), a form of transcranial magnetic stimulation that is shorter and more tolerable than traditional methods. It targets specific brain areas involved in craving and cognitive control, potentially reducing cocaine use and cravings with fewer side effects and shorter session times compared to conventional high-frequency TMS.13467
Research Team
Heather Webber, PhD
Principal Investigator
The University of Texas Health Science Center, Houston
Eligibility Criteria
This trial is for adults with cocaine use disorder who are not seeking treatment, have moderate to severe symptoms, and a recent positive urine test for cocaine. They must understand the consent form and provide contact details. Excluded are those with other substance disorders (except marijuana or nicotine), certain medical conditions, suicidal or homicidal risks, metal implants incompatible with TMS, unsafe medication doses, specific drug use within a week of enrollment or during the study.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive intermittent theta burst stimulation (iTBS) to left dorsolateral prefrontal cortex (dlPFC) and dorsomedial prefrontal cortex (dmPFC) compared to sham
Follow-up
Participants are monitored for changes in electrophysiological indices of reward sensitivity and motivated attention
Treatment Details
Interventions
- Sham iTBS
- TMS to dlPFC
- TMS to dmPFC
Find a Clinic Near You
Who Is Running the Clinical Trial?
The University of Texas Health Science Center, Houston
Lead Sponsor
National Institute on Drug Abuse (NIDA)
Collaborator