This trial is evaluating whether Lumpectomy will improve 2 primary outcomes and 4 secondary outcomes in patients with Stage IA Breast Cancer. Measurement will happen over the course of Up to 3 years after completion of radiation therapy.
This trial requires 176 total participants across 1 different treatment group
This trial involves a single treatment. Lumpectomy is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"If the cancer is diagnosed early enough, and is then treated properly (i.e., at its first stage), it is curable; though it is not ideal that much later, and the tumor can often be dangerous and difficult to stop once it has started." - Anonymous Online Contributor
"There are no signs that reliably diagnose [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer), as is the case with many other cancers. However, some signs of breast cancer are well-known and easily visible, such as fluid-filled (fluctuant), or firm, movable breast masses. Symptoms such as redness, itchiness, or pain in the skin can be signs that there are other problems, such as a new lump in the lymph nodes, but are not signs of breast cancer alone, but in all the cases, are associated with the risk of breast cancer in the future. These symptoms need to be taken seriously if you are diagnosed with a lump in the breast or the discovery of a lump." - Anonymous Online Contributor
"the prevalence rate of breast cancer in Canada is about 10-10% per year, approximately one million new cases per year will develop breast cancer in Canada in 2019 to 2039 assuming present incidence rates." - Anonymous Online Contributor
"The main cause of [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) is exposure to hormone or DNA. There are also possible causes caused by environmental or radiation exposure. It is not clear how one causes the other. Breast enlargement and pregnancy appear to increase the risk of developing breast cancer. There is no clear evidence that breast pain, tender lymph nodes, breast lump or breast cancer risk may be increased by the use of hormones." - Anonymous Online Contributor
"There are four general categories of treatments: surgery, chemotherapy, radiation, and hormonal therapy, which may be individually chosen or combined. Most of the treatments are available to patients in the early stages of breast cancer. But in the late stages, chemotherapy or radiation may be applied, not just at the beginning of treatment but even after the surgery has been carried out. Even if it is too late for surgery, you will need the other treatments and/or medications for the remainder of your life. Thus, we need to develop effective preventive treatments." - Anonymous Online Contributor
"Results from a recent clinical trial corroborate previous findings that mastectomy is unnecessary in patients with early-stage disease. Patients with ER-positive and/or PR-positive breast cancers generally do not live long enough to need a mastectomy, and their disease may be successfully managed with lumpectomy with radiation, aromatase inhibitors and trastuzumab." - Anonymous Online Contributor
"In comparison to breast-conserving therapies, lumpectomy is typically used (1) as a salvage therapy after surgery; (2) in patients who are younger, have larger tumors and have a shorter lifespan (< 60 years); (3) in patients who have low-risk features (triple-negative and HER-2/neu-negative); (4) with neoadjuvant chemotherapy. Nevertheless, breast-conserving therapies are also often used and only when more conservative local-regional treatments (mastectomy, lumpectomy, or other options) are preferred." - Anonymous Online Contributor
"The primary cause of breast carcinoma is unknown in most patients, but genetic factors are a major cause in about 1/3 to 1/4 of patients." - Anonymous Online Contributor
"The existence of a hereditary component of breast cancer is confirmed in the present sample but the contribution of this genetic factor in familial breast cancer may be minimal in this population." - Anonymous Online Contributor
"Lumpectomy does not improve the QoL of women with early-stage [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer). The improvements noted were most frequently associated with the improved likelihood of complete removal of cancer as well as improvements in cosmetic and physical aspects of the patient. Because the breast cancers were all small and the surgery time limited, the surgical outcomes were not different from that for patients undergoing BCT. Because lumpectomy is most often performed when mastectomy is indicated, these improvements in patient QoL should be expected with mastectomy as well." - Anonymous Online Contributor
"There are many factors that influence survival of [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) patients. One of them is age, while gender and ethnicity have little impact on survival or prognosis. One of the things to pay attention to is the quality of cancer care delivered to patients, and the need for regular follow-up after the initiation of treatment; as well as the quality of communication between patient and oncologists/surgeons. There is a clear need to improve the quality of chemotherapy, targeted treatment and/or radiotherapy and to develop a standard treatment protocol for breast cancer." - Anonymous Online Contributor
"No statistically significant differences were seen between the lumpectomy group and the group receiving mastectomy alone with regard to clinical outcomes (locoregional control and disease-free survival). Although these trials have been described as 'randomized,' the quality of their randomization is of concern, and a high-grade-randomized trial is required to assess their validity." - Anonymous Online Contributor