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Imaging Technique

OFDI Imaging for Coronary Artery Disease

N/A
Waitlist Available
Led By Guillermo Tearney, MD, PhD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Undergoing PCTI for coronary artery disease
Women with childbearing potential must have a negative pregnancy test within the 7 days prior to study entry
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

Study Summary

This trial will use a new imaging technique to study the presence of a specific type of plaque in people with coronary artery disease.

Who is the study for?
This trial is for people with coronary artery disease who are undergoing a procedure called PCTI. Women of childbearing age must test negative for pregnancy before joining. People can't join if they have kidney issues, recent heart attacks, complex heart lesions, severe vascular disease, congestive heart failure, previous bypass surgery or are in another study.Check my eligibility
What is being tested?
The trial is testing a new imaging method called OFDI to spot vulnerable plaques in the arteries that could lead to heart attacks. It aims to see how well this technique works in identifying these risky plaques compared to current methods.See study design
What are the potential side effects?
Since OFDI is an imaging technique and not a drug or invasive treatment, side effects may be minimal but could include discomfort during the imaging process or potential risks associated with additional exposure during PCTI.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am receiving treatment for blocked heart arteries.
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I am a woman who can have children and I have a negative pregnancy test from the last week.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Determine prevalence of vulnerable plaques

Trial Design

2Treatment groups
Experimental Treatment
Group I: OFDI imagingExperimental Treatment1 Intervention
OFDI catheter advanced to the distal coronary artery
Group II: Intravenous UltrasoundExperimental Treatment1 Intervention
Randomization to determine whether Intravenous Ultrasound will be conducted before or after OFDI imaging.

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,918 Previous Clinical Trials
13,192,515 Total Patients Enrolled
21 Trials studying Coronary Artery Disease
10,188 Patients Enrolled for Coronary Artery Disease
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,814 Previous Clinical Trials
47,290,555 Total Patients Enrolled
165 Trials studying Coronary Artery Disease
268,712 Patients Enrolled for Coronary Artery Disease
Guillermo Tearney, MD, PhDPrincipal InvestigatorMassachusetts General Hospital
8 Previous Clinical Trials
835 Total Patients Enrolled

Media Library

OFDI imaging (Imaging Technique) Clinical Trial Eligibility Overview. Trial Name: NCT00540761 — N/A
Coronary Artery Disease Research Study Groups: OFDI imaging, Intravenous Ultrasound
Coronary Artery Disease Clinical Trial 2023: OFDI imaging Highlights & Side Effects. Trial Name: NCT00540761 — N/A
OFDI imaging (Imaging Technique) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00540761 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there vacancies in this clinical experiment which individuals can take part in?

"According to the clinicaltrials.gov data, this particular trial is not actively searching for participants. It was initially posted in 2007 and last updated in 2021. However, there are currently 571 other trials recruiting patients as of now."

Answered by AI
~18 spots leftby Mar 2025