OFDI Imaging for Coronary Artery Disease
Trial Summary
What is the purpose of this trial?
Atherosclerosis, a condition in which fatty deposits of plaque build up along the inner walls of arteries, is a condition that may increase the risk of having a heart attack. Previous studies have shown that the presence of a specific kind of plaque, known as vulnerable plaque, is often found in people who have had a heart attack. This study will use a new imaging technique called optical frequency domain imaging (OFDI) to examine the presence of vulnerable plaques in people with coronary artery disease.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
How does OFDI imaging differ from other treatments for coronary artery disease?
OFDI imaging (Optical Frequency Domain Imaging) is unique because it provides high-resolution images of the coronary arteries, allowing for detailed visualization of plaque and vessel structure, which is not possible with other noninvasive imaging techniques like MRI or CT scans. This can help in better understanding the progression of coronary artery disease and tailoring treatment strategies.12345
Research Team
Guillermo Tearney, MD, PhD
Principal Investigator
Massachusetts General Hospital
Eligibility Criteria
This trial is for people with coronary artery disease who are undergoing a procedure called PCTI. Women of childbearing age must test negative for pregnancy before joining. People can't join if they have kidney issues, recent heart attacks, complex heart lesions, severe vascular disease, congestive heart failure, previous bypass surgery or are in another study.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Imaging and Angioplasty
Participants undergo baseline angiography, followed by randomization to IVUS and OFDI imaging procedures, and then angioplasty with stent placement.
Follow-up Imaging
Participants undergo repeat IVUS and OFDI procedures to evaluate changes in heart blood vessels and plaque.
Long-term Follow-up
Participants complete questionnaires about medication history and heart problems every six months for two years.
Treatment Details
Interventions
- OFDI imaging
Find a Clinic Near You
Who Is Running the Clinical Trial?
Massachusetts General Hospital
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator