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PCEA vs IV PCA for Postoperative Pain Management After Liver Surgery

Phase 3

Waitlist Available

Led By Vittoria Arslan-Carlon, MD

Research Sponsored by Memorial Sloan Kettering Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 year

Awards & highlights

Study Summary

This trial will compare patient-controlled epidural analgesia (PCEA) to the current standard of care, IV PCA, to see if PCEA is a better method for managing pain after liver resection.

Who is the study for?

Adults over 18 who can consent and are undergoing elective liver resection for liver disease, including additional surgeries, without contraindications to epidural catheter insertion. Excluded are those with allergies to study drugs, pain at rest or movement (NRS >2), opioid agonist/antagonist use, bleeding disorders, neurological issues, extensive spinal history or deformity, certain pre-op coagulopathy levels or infections at the epidural site.Check my eligibility

What is being tested?

The trial is testing if patient-controlled epidural analgesia (PCEA) manages post-operative pain better than the standard intravenous patient-controlled analgesia (IV PCA) after liver resection surgery. It aims to compare daily pain relief and mobility between these two methods.See study design

What are the potential side effects?

Potential side effects may include reactions to medications like dilaudid, fentanyl, bupivacaine such as itching or rash; complications from catheter placement like infection; and typical anesthesia-related risks such as headaches or low blood pressure.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

ability to detect a 2-point NRS scale difference

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: PCEA during and after surgeryExperimental Treatment1 Intervention

general anesthesia with post-operative thoracic epidural analgesia with a standard demand pump

Group II: IV PCA after surgeryActive Control1 Intervention

general anesthesia with post-operative IV PCA with a standard demand pump

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor

1,933 Previous Clinical Trials

585,389 Total Patients Enrolled

20 Trials studying Liver Cancer

7,615 Patients Enrolled for Liver Cancer

Vittoria Arslan-Carlon, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center

1 Previous Clinical Trials

282 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What percentage of patients experience complications from PCEA?

"There is some evidence to support the efficacy of PCEA, as it has reached Phase 3 in clinical trials. Furthermore, multiple rounds of data collection have determined that PCEA is safe, and so it receives a score of 3."

Answered by AI

Are there any patients that you are still enrolling in this program?

"This particular clinical trial is not taking any more patients at the moment, however it was last updated on 9/13/2022. There are 667 other trials searching for participants that you may be eligible for."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Patient Controlled Epidural Analgesia Versus Intravenous Patient Controlled Analgesia for Post-Operative Pain Control in Patients Undergoing Elective Liver Resection

2015. "Patient Controlled Epidural Analgesia Versus Intravenous Patient Controlled Analgesia for Post-Operative Pain Control in Patients Undergoing Elective Liver Resection". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02523443.