← Back to Search

Mango for Prediabetes

N/A

Waitlist Available

Led By Celine Heskey, DrPH

Research Sponsored by Loma Linda University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Abdominal obesity as defined as a waist circumference >102 cm for men or >88 cm for women

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up fat mass will be measured at weeks 0, 4, 8, 12, 16, 20, 24, 28

Awards & highlights

Study Summary

This trial tests the effect of eating 1.5 cups of mango per day for 12 weeks on indicators of glycemia, insulin resistance, lipids, inflammation, oxidation and body composition in people with prediabetes.

Who is the study for?

This trial is for individuals with prediabetes, indicated by HgbA1c levels of 5.7 to 6.4%, and abdominal obesity (waist >102 cm for men, >88 cm for women). Excluded are those with chronic diseases, pacemakers, mango or latex allergies, smokers, high alcohol consumers (>2 drinks/day for men or >1 drink/day for women), recent significant weight loss (>5% in past 6 months), BMI over 35 kg/m^2, pregnant or breastfeeding women, on certain medications/supplements affecting blood sugar/lipids or who regularly consume lots of mangos/fruits.Check my eligibility

What is being tested?

The study tests if eating 1.5 cups of fresh mango daily over a period of 12 weeks can improve glucose control and insulin resistance in people with prediabetes. It also looks at the effects on cholesterol levels (LDL/HDL/total/triglycerides), oxidative stress markers like oxidized LDL-cholesterol and inflammation indicators such as c-reactive protein. Participants will alternate between consuming mangos and not consuming them to compare changes.See study design

What are the potential side effects?

Potential side effects from consuming mangos may include digestive issues like bloating or gas due to increased fiber intake; however specific side effects related to this intervention have not been detailed.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My waist is over 102 cm if I am a man, or over 88 cm if I am a woman.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ fat mass will be measured at weeks 0, 4, 8, 12, 16, 20, 24, 28

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~fat mass will be measured at weeks 0, 4, 8, 12, 16, 20, 24, 28

This trial's timeline: 3 weeks for screening, Varies for treatment, and fat mass will be measured at weeks 0, 4, 8, 12, 16, 20, 24, 28 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

8-iso-PGF2 alpha

Fasting blood glucose

Fasting blood insulin

+7 more

Secondary outcome measures

C-reactive protein

E-selectin

Fat mass

+4 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Mango added to habitual dietExperimental Treatment1 Intervention

Participants will be asked to consume 1.5 cups of mango per day for 12 weeks as part of their habitual diet.

Group II: Habitual diet without mangoActive Control1 Intervention

Participants will be asked to refrain consuming mangos for 12 weeks while continuing their habitual diet.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Mango

2022

Completed Phase 1

~270

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Loma Linda UniversityLead Sponsor

306 Previous Clinical Trials

260,957 Total Patients Enrolled

9 Trials studying Inflammation

358 Patients Enrolled for Inflammation

National Mango BoardOTHER

6 Previous Clinical Trials

286 Total Patients Enrolled

Celine Heskey, DrPHPrincipal InvestigatorLoma Linda University

1 Previous Clinical Trials

59 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it possible to join this clinical experiment?

"This study is scouting 31 volunteers with elevated blood sugar levels and within the age bracket of 40 to 60. To be considered, these criteria must be met."

Answered by AI

Are geriatric patients considered acceptable participants for this trial?

"The age range for inclusion in this trial is 40 to 60 years old. For comparison, there are 73 clinical trials requiring patients under 18 and 573 studies involving individuals over 65."

Answered by AI

Is this trial currently enrolling participants?

"Upon inspection of the clinicaltrials.gov website, it appears this trial is not actively seeking patients at present. Initially posted on February 1st 2024 and last edited November 28th 2023, no additions have been made since then. Fortunately, there are 776 other investigations currently recruiting participants for enrollment."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes

Celine Heskey 2024. "The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06159543.

All > Prediabetes