Blood Draw Monitoring for Acute Phase Response Post-Injury
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of the proposed study is to test these hypotheses through the following aims:1. To determine if early plasmin activation following severe injury correlates with SIRS, TIC and complications throughout convalescence in both trauma and surgical patients.2. To determine if early plasmin activation following severe injury correlates with plasminogen consumption and poor plasmin activity later in convalescence.
Will I have to stop taking my current medications?
If you are a healthy volunteer, you cannot participate if you are taking anticoagulant medication or NSAIDs. For trauma or surgical patients, the protocol does not specify if you need to stop your current medications.
Is blood draw generally safe for humans?
How does this treatment for acute phase response post-injury differ from other treatments?
This treatment is unique because it focuses on monitoring blood draws to observe the acute phase response, which is an early defense system activated by injury. Unlike other treatments that might directly target symptoms or complications, this approach aims to understand the body's natural healing process and immune response after an injury.678910
Who Is on the Research Team?
Jonathan Schoenecker, MD, PhD
Principal Investigator
Vanderbilt University Medical Center
Are You a Good Fit for This Trial?
This trial is for patients aged 2 months to 70 years who are undergoing high-risk surgery or have been admitted to the trauma unit. They must weigh over 110lbs and not be on anticoagulants, NSAIDs, hormone therapies, or have chronic conditions like diabetes.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Hospitalization
Patients have blood drawn pre-, intra-, and post-operatively, and at regular intervals during hospitalization for analysis
Follow-up
Any complications resulting from surgery or traumatic injury will be documented at routine care visits
What Are the Treatments Tested in This Trial?
Interventions
- Blood draw (venipuncture or fingerstick)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Vanderbilt University Medical Center
Lead Sponsor