Transcranial Direct Current Stimulation for Aging
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether transcranial direct current stimulation (tDCS) can help older adults with memory concerns improve brain function and walking speed. Participants will receive either the actual treatment or a sham version while walking and performing mental tasks. The trial seeks individuals who have noticed a decline in memory or thinking, do not have dementia, can walk unaided for ten minutes, and have a family history of Alzheimer's disease. As an unphased trial, this study provides a unique opportunity to contribute to groundbreaking research that could enhance memory and mobility in older adults.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it mentions that medications altering cortical excitability may affect eligibility. It's best to discuss your specific medications with the trial team.
What prior data suggests that transcranial direct current stimulation is safe for older adults with subjective cognitive decline?
Research has shown that transcranial direct current stimulation (tDCS) is generally safe for adults, including older individuals. A review of over 1,000 participants found tDCS safe for adults, teenagers, and the elderly. Another study confirmed its practicality and safety, even for frail older adults.
While some studies have shown mixed results regarding cognitive benefits, the safety record remains strong. Participants in various studies experienced only minor side effects, such as tingling or a mild headache.
Overall, evidence suggests that tDCS is well-tolerated and unlikely to cause significant side effects in older adults.12345Why are researchers excited about this trial?
Researchers are excited about transcranial direct current stimulation (tDCS) for aging because it offers a non-invasive way to potentially boost brain function. Unlike traditional treatments for cognitive decline that often involve medication, tDCS uses low electrical currents applied to the scalp to stimulate the brain directly. This method targets the vestibular cortex, which may help improve balance and spatial orientation, areas that often decline with age. The promise of enhancing cognitive abilities without drugs makes this approach particularly appealing.
What evidence suggests that transcranial direct current stimulation is effective for aging-related cognitive decline?
Research suggests that transcranial direct current stimulation (tDCS) might aid memory and thinking skills as people age. Some studies have found that tDCS can enhance mental performance in older adults, especially when combined with brain exercises. However, its effectiveness varies among individuals. In this trial, participants will join either an active stimulation group or a sham stimulation group to assess the effects of tDCS. While some older adults experience benefits, others may not notice any changes. Nonetheless, researchers consider tDCS a promising method to support brain health in aging adults.46789
Who Is on the Research Team?
Rachael Seidler
Principal Investigator
University of Florida
Are You a Good Fit for This Trial?
This trial is for older adults who feel their cognitive abilities have declined but do not show clinical signs of dementia or mild cognitive impairment. They must be able to walk unassisted, speak English, and have at least an 8th-grade reading level. A family history of Alzheimer's disease is required, along with normal scores on specific neuropsychological tests.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-test
Participants perform a walking + spatial navigation task to establish baseline behavioral scores
Treatment
Participants receive either active or sham tDCS while performing walking + spatial navigation tasks
Post-test
Participants undergo MRI scans to assess changes in brain network segregation
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Transcranial Direct Current Stimulation
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Florida
Lead Sponsor
National Institute on Aging (NIA)
Collaborator