YORS for Opioid Use Disorder
(YORS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The trial aims to test a new approach called the Youth Opioid Recovery Support (YORS) model. This model helps young adults with opioid use disorder (OUD) adhere to their treatment plans through home delivery of medication, family involvement, outreach, and incentives. Participants will either receive the YORS treatment or continue with their usual care. This trial suits young adults aged 18-28 with an OUD diagnosis who are open to involving a family member in their treatment. As an unphased trial, it offers a unique opportunity to contribute to innovative research that could shape future treatment strategies.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, since the trial involves treatment with specific medications (XR-NTX or XR-BUP), it's best to discuss your current medications with the trial team.
What prior data suggests that the YORS model is safe for young adults with opioid use disorder?
Research shows that the Youth Opioid Recovery Support (YORS) model uses innovative methods, such as home delivery of medication and family involvement in treatment. These components aim to help young adults remain committed to their treatment for opioid use disorder (OUD). Although specific safety data for YORS is not yet available, one of its key medications, extended-release naltrexone, has already received FDA approval for treating OUD. This approval indicates that the medication is generally considered safe. Additionally, because the YORS model emphasizes support and outreach without introducing new drugs, it likely presents fewer safety concerns.12345
Why are researchers excited about this trial?
Researchers are excited about the Youth Opioid Recovery Support (YORS) because it offers a fresh approach to helping young adults with opioid use disorder. Unlike standard treatments, which often rely on clinic visits for medication, YORS includes home delivery of extended-release naltrexone, making it easier for patients to stick to their treatment plans. Another standout feature is the active involvement of families in the treatment process, which can improve medication adherence. Additionally, the use of assertive outreach techniques like text messaging and social media keeps patients engaged and on track with their recovery. These innovative components aim to address some of the biggest challenges in treating this vulnerable population and could make a significant difference in their recovery journey.
What evidence suggests that the YORS model is effective for opioid use disorder?
Research has shown that the Youth Opioid Recovery Support (YORS) model, a treatment option in this trial, can significantly assist young adults dealing with opioid addiction. The YORS model improves medication adherence by delivering extended-release naltrexone to participants' homes, which helps reduce opioid cravings. Studies suggest that involving families in treatment, actively reaching out to participants, and offering rewards for adherence help young people remain committed. This approach has shown promise in increasing the number of doses participants take and reducing their opioid use. Overall, YORS aims to simplify treatment adherence for young adults and enhance recovery outcomes.12346
Who Is on the Research Team?
Marc Fishman, MD
Principal Investigator
Maryland Treatment Centers
Are You a Good Fit for This Trial?
This trial is for young adults aged 18-28 with opioid use disorder who are willing to take relapse prevention medications and involve a family member or significant other in their treatment. It's not suitable for those living too far from the center, experiencing homelessness, or dealing with severe psychiatric or medical conditions.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Stakeholder Input and Pilot Testing
Conduct stakeholder focus groups and 3 cycles of pilot testing for intervention refinements
Randomized Controlled Trial (RCT)
Participants are randomized to either the refined YORS intervention or treatment as usual (TAU) for a 6-month course of treatment with XR-NTX
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Youth Opioid Recovery Support (YORS)
Trial Overview
The YORS intervention is being tested to see if it helps young adults stick to their medication plans and stay engaged in treatment. The study includes refining the program through feedback and then testing its effectiveness compared to standard care.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
The Youth Opioid Recovery Support (YORS) model is an innovative wrap-around approach that attempts to address barriers to treatment engagement in this vulnerable young adult population, especially difficulties with medication adherence. Its components include: (1) Home delivery of extended release naltrexone (XR-NTX) for OUD; (2) Engagement of families in collaborative treatment planning and monitoring focusing on medication adherence; (3) Assertive outreach from the treatment team including actively tracking and communicating with youth and families by text messaging and social media to promote engagement and adherence; and (4) Contingency management to provide incentives for medication adherence. The specific components of YORS will be refined and adapted based on feedback from interviews and focus groups with various stakeholders. However, the basic framework outlined above is expected to persists.
TAU will contain patients who will be receiving treatment for opioid use disorder through their usual venues without the family engagement, assertive outreach, contingency management, and home delivery of medication. This often includes a referral and warm hand off to intensive outpatient SUD services and/or mental health care.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Potomac Health Foundations
Lead Sponsor
Friends Research Institute, Inc.
Collaborator
National Institute on Drug Abuse (NIDA)
Collaborator
National Center for Complementary and Integrative Health (NCCIH)
Collaborator
National Institutes of Health (NIH)
Collaborator
Published Research Related to This Trial
Citations
The Youth Opioid Recovery Support (YORS) Intervention ...
It is hypothesized that participants in the YORS condition will receive significantly more XR-NTX doses and will demonstrate less severe opioid use and ...
The Youth Opioid Recovery Support (YORS) Intervention
The Youth Opioid Recovery Support (YORS) model is an innovative wraparound approach that attempts to address barriers to treatment engagement in ...
Youth Opioid Recovery Support: Improving Care Systems
The Youth Opioid Recovery Support (YORS) treatment delivery model hopes to address barriers to retention to substance treatment among those with opioid use ...
Choice of extended release medication for OUD in young ...
The YORS intervention aims to improve outcomes for youth with opioid use disorder. · Assertive outreach is used to improve extended release medication adherence.
Intervention for Young People Aims to Lift Barriers ...
Support system model encourages young adults to access and continue medication-based treatment to achieve long-term recovery.
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trialx.com
trialx.com/clinical-trials/listings/261125/the-youth-opioid-recovery-support-yors-intervention/The Youth Opioid Recovery Support (YORS) Intervention
Young people are disproportionately affected by the current opioid crisis including worse retention and outcomes compared to older adults.
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