YORS for Opioid Use Disorder
(YORS Trial)
Trial Summary
What is the purpose of this trial?
Youth are disproportionately affected by the current opioid crisis with catastrophic consequences, and young adults with opioid use disorder (OUD) often struggle with adherence to relapse prevention medications. The Youth Opioid Recovery Support (YORS) model is a promising, innovative, wrap-around approach that addresses barriers to medication adherence and treatment engagement in an effort to improve public health outcomes in this vulnerable young adult population. This study seeks to refine the YORS intervention through stakeholder input and pilot iterative testing followed by an efficacy randomized controlled trial. This project will significantly contribute to our knowledge base of practical strategies to address the opioid crisis.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, since the trial involves treatment with specific medications (XR-NTX or XR-BUP), it's best to discuss your current medications with the trial team.
What data supports the effectiveness of the Youth Opioid Recovery Support (YORS) treatment for opioid use disorder?
The YORS treatment is designed to improve engagement and medication adherence in young adults with opioid use disorder by using strategies like home delivery of medications and assertive outreach. Initial feedback from patients and staff is positive, suggesting it may be a promising approach to enhance care and reduce opioid relapse.12345
Is the Youth Opioid Recovery Support (YORS) intervention safe for humans?
How is the YORS treatment different from other treatments for opioid use disorder?
The YORS treatment is unique because it focuses on improving adherence to extended-release medications for opioid use disorder through assertive outreach and home delivery, making it easier for young adults to stay engaged in their treatment. It also adapts to challenges like the COVID-19 pandemic by using mobile van delivery to reduce exposure risks.12346
Research Team
Marc Fishman, MD
Principal Investigator
Maryland Treatment Centers
Eligibility Criteria
This trial is for young adults aged 18-28 with opioid use disorder who are willing to take relapse prevention medications and involve a family member or significant other in their treatment. It's not suitable for those living too far from the center, experiencing homelessness, or dealing with severe psychiatric or medical conditions.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Stakeholder Input and Pilot Testing
Conduct stakeholder focus groups and 3 cycles of pilot testing for intervention refinements
Randomized Controlled Trial (RCT)
Participants are randomized to either the refined YORS intervention or treatment as usual (TAU) for a 6-month course of treatment with XR-NTX
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Youth Opioid Recovery Support (YORS)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Potomac Health Foundations
Lead Sponsor
Friends Research Institute, Inc.
Collaborator
National Institute on Drug Abuse (NIDA)
Collaborator
National Center for Complementary and Integrative Health (NCCIH)
Collaborator
National Institutes of Health (NIH)
Collaborator