High Calcium, Low Sodium (HCLS) Crystalloid Therapy for Cardiac Arrest

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Cardiac Arrest+1 MoreHigh Calcium, Low Sodium (HCLS) Crystalloid Therapy - Drug
Eligibility
18+
All Sexes
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Study Summary

This trial is studying whether a high calcium, low sodium fluid given to patients with pulseless electrical activity (PEA) in pre-hospital care will improve the chances of survival.

Eligible Conditions
  • Cardiac Arrest

Treatment Effectiveness

Study Objectives

1 Primary · 4 Secondary · Reporting Duration: Through resuscitation efforts up to 1 hour after arrival to (ED) Emergency Department

Hour 1
Any Return-Of-Spontaneous-Circulation (ROSC)
Up to 1 hour
Event Survival
Hour 12
Serum Electrolyte Values
Day 30
Survival to hospital discharge
Day 30
Neurological outcome at hospital discharge

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

High-Calcium, High- Sodium (HCHS) group
1 of 2
High-Calcium, Low- Sodium (HCLS) group
1 of 2

Active Control

Experimental Treatment

342 Total Participants · 2 Treatment Groups

Primary Treatment: High Calcium, Low Sodium (HCLS) Crystalloid Therapy · No Placebo Group · Phase 2 & 3

High-Calcium, Low- Sodium (HCLS) group
Drug
Experimental Group · 1 Intervention: High Calcium, Low Sodium (HCLS) Crystalloid Therapy · Intervention Types: Drug
High-Calcium, High- Sodium (HCHS) group
Drug
ActiveComparator Group · 1 Intervention: High Calcium, High Sodium (HCHS) Crystalloid Therapy · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: through resuscitation efforts up to 1 hour after arrival to (ed) emergency department

Who is running the clinical trial?

Virginia Polytechnic Institute and State UniversityOTHER
112 Previous Clinical Trials
25,531 Total Patients Enrolled
Carol BernierLead Sponsor
Carol Bernier, DOPrincipal InvestigatorVirginia Polytechnic Institute and State University

Eligibility Criteria

Age 18+ · All Participants · 1 Total Inclusion Criteria

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