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Thermal Therapy

The TRANBERGCLS|Thermal Therapy for Prostate Cancer (MRgFLA Trial)

N/A
Waitlist Available
Led By Sangeet Ghai, MD
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Suspicious site on Prostate MRI must coincide with sector positive for cancer on biopsy.
Prostate specific antigen (PSA) level less than 15 ng/mL
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 months after treatment completion
Awards & highlights

MRgFLA Trial Summary

This study is evaluating whether a surgery which destroys cancer cells in the prostate can be done safely.

Eligible Conditions
  • Prostate Cancer

MRgFLA Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

MRgFLA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 months after treatment completion
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 months after treatment completion for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The proportion of study patients clinically free of clinically significant PCa (i.e. requires definitive treatment)
Secondary outcome measures
Treatment effect on patients' Quality of Life (QoL), the following validated self-reported urogenital functioning assessment instruments will be used before and following treatment at pre-specified interval

MRgFLA Trial Design

1Treatment groups
Experimental Treatment
Group I: Single arm prospective clinical trialExperimental Treatment1 Intervention
This is a single arm study where patients with low-intermediate risk MR visible locally confined prostate cancer will be treated with focal laser ablation under MRI guidance in the magnet. Following treatment, the patients will be assessed by MRI and Biopsy at 6 months and at 2 years, with PSA assessment at regular intervals during the time

Find a Location

Who is running the clinical trial?

University Health Network, TorontoLead Sponsor
1,456 Previous Clinical Trials
482,823 Total Patients Enrolled
63 Trials studying Prostate Cancer
15,390 Patients Enrolled for Prostate Cancer
Clinical Laserthermia Systems ABIndustry Sponsor
7 Previous Clinical Trials
46 Total Patients Enrolled
Sangeet Ghai, MDPrincipal InvestigatorDirector; Biopsy Centre, Abdominal Division and Joint Department of Medical Imaging
2 Previous Clinical Trials
153 Total Patients Enrolled
1 Trials studying Prostate Cancer
53 Patients Enrolled for Prostate Cancer

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~7 spots leftby Mar 2025