CLINICAL TRIAL

MISSION Critical Time Intervention for Disease

1 Prior Treatment
Relapsed
Recruiting · 18+ · All Sexes · Springfield, MA

Supporting Treatment Access and Recovery in COD

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About the trial for Disease

Eligible Conditions
Disease · Mental Disorders · Opioid-Related Disorders · Opioid Use Disorder (OUD) · Mental Health Disorders

Treatment Groups

This trial involves 4 different treatments. MISSION Critical Time Intervention is the primary treatment being studied. Participants will be divided into 4 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
MISSION Dual Recovery Therapy
BEHAVIORAL
+
Medication for Opioid Use Disorder
OTHER
+
MISSION Critical Time Intervention
BEHAVIORAL
Experimental Group 2
MISSION Dual Recovery Therapy
BEHAVIORAL
+
Medication for Opioid Use Disorder
OTHER
+
MISSION Peer Support
BEHAVIORAL
+
MISSION Critical Time Intervention
BEHAVIORAL
Experimental Group 3
MISSION Dual Recovery Therapy
BEHAVIORAL
+
Medication for Opioid Use Disorder
OTHER
+
MISSION Peer Support
BEHAVIORAL
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Eligibility

This trial is for patients born any sex aged 18 and older. You must have received 1 prior treatment for Disease or one of the other 4 conditions listed above. There are 6 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
The study will include two groups of patients: those who are newly admitted into the program with OUD; and those who have been active in the program for the treatment of OUD with medications like buprenorphine or naltrexone, but experienced a recent relapse with any substance show original
Many people with opioid addiction also have a concurrent substance use disorder, such as alcohol or cocaine addiction. show original
Have a co-occurring mental health disorder (COD) including depression, anxiety, trauma-related disorders, bipolar, and/or schizophrenia, and those who are stable on buprenorphine or naltrexone but have recurrence or worsening at any time of symptoms of any co-occurring mental health disorder (COD) including depression, anxiety, trauma-related disorders, bipolar, and/or schizophrenia, even if the patient has not relapsed. Instability is defined in two ways in the study: (a) a substance use relapse; and (b) recurrence to symptom exacerbation in regard to a subject's mental health disorder(s). If subjects do not meet criteria for "a" (i.e., not having a substance use relapse), but they do meet criteria for "b" (i.e., they do in fact have worsening of mental health symptoms), they are then defined as unstable, and will meet study inclusion criteria.
This refers to people who are 18 years old or older. show original
Are proficient in English or Spanish; Speak English or Spanish fluently. show original
Able to provide consent;
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 12 months
Screening: ~3 weeks
Treatment: Varies
Reporting: 12 months
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 12 months.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether MISSION Critical Time Intervention will improve 17 primary outcomes, 1 secondary outcome, and 5 other outcomes in patients with Disease. Measurement will happen over the course of Baseline.

Psychiatric severity
BASELINE
Measured by Structured Clinical Interview for DSM-5 (SCID-RV)
BASELINE
Overall well-being
6 MONTHS
Measured by EQ-5D-5L
6 MONTHS
Economic impact of MOUD alone
6 MONTHS
Cost of MOUD alone measured by PROPr
6 MONTHS
Engagement in outreach and linkage sessions
6 MONTHS
Measured by total number of outreach and linkage sessions
6 MONTHS
Economic impact of full MISSION
6 MONTHS
Cost of full MISSION and MOUD measured by Patient-Reported Outcomes Measurement Information System-Preference (PROPr)
6 MONTHS
Engagement in medication for opioid use disorder (MOUD)
6 MONTHS
Measured by percentage of days receiving MOUD
6 MONTHS
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Who is running the study

Principal Investigator
D. S.
Prof. David Smelson, Professor
University of Massachusetts, Worcester

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get disease a year in the United States?

This analysis provides a preliminary overview of the lifetime risk of disease in the United States, and should encourage further studies of the prevalence of various disease in the US population.

Anonymous Patient Answer

What causes disease?

Symptoms may be the result of factors outside the body, such as in the environment. The role of the body is to produce a set of body functions and organs that work together to ensure health. The result of disease is an alteration to the body, which may be a source of symptoms.

Anonymous Patient Answer

What are the signs of disease?

The signs of disease include, but are not limited to: excessive weight gain, lack of physical activity, an increase in appetite, a change in appetite, a dry and thickened skin, dry and rough skin, an increase in hair loss, change in menstrual cycles, swollen ankles, swelling on the chest, and swollen toes. Diabetes can also be a sign of disease.\n

Anonymous Patient Answer

What are common treatments for disease?

A major limitation of the review is that no evidence-based guideline was found for most conditions. There were no guideline for dermatological or cardiovascular disease, and only one guideline that assessed the quality of evidence on surgical treatment was of poor quality.

Anonymous Patient Answer

Can disease be cured?

Disease can't be cured – it is a subjective experience of patients with different diseases. The only cure for patients is empathy in patient-clinician interaction based on shared experience of the disease.

Anonymous Patient Answer

What is disease?

Disease is an umbrella term that encompasses all factors that affect an individual and their environment, including disease itself, and its effects. It can be broken down here into three categories: (i) health disorders/health status, (ii) environmental/social factors and (iii) individual attributes. These categories, collectively, describe the social and environmental context in which everyone lives and operate; a vital distinction in disease research that has received little attention by the pharmaceutical industry.

Anonymous Patient Answer

How serious can disease be?

These data provide a benchmark to monitor disease severity in the coming 10 years. Disease progression will accelerate if disease-related factors continue to increase, which reinforces that disease severity is an individualization of health needs that depends on factors such as genetic and environmental factors, the individual's state of health.

Anonymous Patient Answer

What is the latest research for disease?

The following are three major themes used to research disease. 1. Vaccines targeting new diseases: vaccines targeting new diseases for the purpose of disease control are the hottest research topics today. Many different vaccines targeting new diseases are currently in clinical trials, such as [HIV vaccine (gp46peptide-hsa-nipahvaxia)(Baxter)].

Anonymous Patient Answer

What are the common side effects of mission critical time intervention?

Mission critical time intervention has common side effects, including anxiety, panic disorders, and exhaustion. We recommend that training courses should be mandatory when the intervention is used to improve performance.

Anonymous Patient Answer

Who should consider clinical trials for disease?

Almost one-third of the patients (29%) did not consider a clinical trial and the number of patients who do not consider a clinical trial may be even higher during other clinical trials and in the future. Therefore, efforts should be exerted to enhance patients' information and knowledge on clinical trials.

Anonymous Patient Answer

What are the latest developments in mission critical time intervention for therapeutic use?

In MCTI, a clinician's primary patient-centered role is to be aware of the patient's condition, and to communicate on an ongoing basis with the other members of the team as well as the technical team to provide timely and appropriate care.

Anonymous Patient Answer

What is the primary cause of disease?

In the past, this was a controversial question relating to what was referred to as a 'triumvirate of disease' which included the 'genes, environment and drugs'. However, the current consensus (according to the evidence presented in this issue) is that the most important cause of all chronic diseases is 'diet'. In particular, chronic diseases (diseases which persist over lengthy periods of time) may be substantially reduced by reducing intake of carbohydrates and cholesterol and/or increasing consumption of fiber (a component of 'healthy' dietary fibers) and certain fruits and vegetables. (https://www.ncbi.nlm.nih.

Anonymous Patient Answer
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