Intermittent Fasting for Brain Health
Trial Summary
Do I need to stop my current medications for the trial?
The trial protocol does not specify if you need to stop taking your current medications. However, if you are diabetic and taking certain medications like sulfonylureas, meglitinides, or insulin, you cannot participate in the trial.
What data supports the effectiveness of the treatment Intermittent Fasting for brain health?
Research shows that intermittent fasting may have benefits for brain health, particularly in conditions like epilepsy, Alzheimer's disease, and multiple sclerosis, by improving disease symptoms and progress. Animal studies suggest potential benefits for other brain-related disorders, but more human studies are needed to confirm these effects.12345
Is intermittent fasting safe for humans?
Research on alternate-day fasting, a type of intermittent fasting, shows it is generally safe for weight loss in both obese and non-obese individuals, with no major safety concerns reported. However, more studies are needed to fully understand its long-term effects on health beyond weight loss.46789
How does intermittent fasting differ from other treatments for brain health?
Intermittent fasting is unique because it involves alternating periods of eating and fasting, which can lead to changes in brain function through metabolic, cellular, and circadian mechanisms. Unlike traditional treatments that may focus on medication or supplements, intermittent fasting leverages the body's natural processes to potentially improve brain health and cognitive function.1231011
What is the purpose of this trial?
The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through activation of SIRT1-dependent vasoprotective pathways.
Research Team
Andriy Yabluchanskiy, MD, PhD
Principal Investigator
University of Oklahoma
Eligibility Criteria
This trial is for individuals aged between 55 and 80 who can read, write, and understand English. They should be mentally competent to consent and have a Mini-Mental State Exam score of at least 24. It's not suitable for those with major psychiatric diseases, uncontrolled substance abuse issues, certain diabetics on specific medications, or anyone with recent severe brain-related health events.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants adhere to a time restricted eating schedule with a 10-hour eating window each day
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Intermittent Fasting
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Oklahoma
Lead Sponsor
National Institute on Aging (NIA)
Collaborator