Turmeric for Arthrosis

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Massachusetts General Hospital, Boston, MA
Arthrosis+2 More
Turmeric - DietarySupplement
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a commercially available nutraceutical, turmeric, is an effective option to manage pain and stiffness in patients with basal joint arthritis.

See full description

Eligible Conditions

  • Arthrosis
  • Osteoarthritis Thumbs

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Compared to trials

Study Objectives

This trial is evaluating whether Turmeric will improve 2 primary outcomes in patients with Arthrosis. Measurement will happen over the course of Enrollment, 6 weeks, and 3 months.

Month 3
Change in baseline disability
Change in baseline pain intensity

Trial Safety

Safety Estimate

1 of 3

Compared to trials

Trial Design

2 Treatment Groups

Turmeric
1 of 2
Control
1 of 2
Experimental Treatment
Non-Treatment Group

This trial requires 20 total participants across 2 different treatment groups

This trial involves 2 different treatments. Turmeric is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Turmeric
DietarySupplement
Subjects in this group will receive turmeric (100 mg pastille) 3 times per day for 6 weeks.
Control
Other
Subjects in this group will receive a placebo pill 3 times per day for 6 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Turmeric
2011
Completed Phase 3
~450

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: enrollment, 6 weeks, and 3 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly enrollment, 6 weeks, and 3 months for reporting.

Who is running the study

Principal Investigator
N. C. C.
Neal Chung-Jen Chen, MD
Massachusetts General Hospital

Closest Location

Massachusetts General Hospital - Boston, MA

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
40 years of age or older
English fluency and literacy
Seeking care for basal joint pain
Tender over basal joint
Positive distraction rotation test (rotation of the thumb metacarpal base while applying axial traction)
Radiographic evidence of Eaton stage 1 and 2 only

Patient Q&A Section

How many people get arthritis a year in the United States?

"Approximately half of adults (48.6%) have arthritis at some time over their lifetimes. Women and women over 60 may have a greater likelihood of being diagnosed with arthritis." - Anonymous Online Contributor

Unverified Answer

What are common treatments for arthritis?

"The most common treatments for arthritis are oral medications, acupuncture, physical therapy, or a combination of oral medications and physical therapy. The first two procedures are most commonly performed by a health professional." - Anonymous Online Contributor

Unverified Answer

What are the signs of arthritis?

"Arthritis involves the joint membranes and the synovium. Signs of arthritis can include swelling, pain, redness, heat, and decreased range of movement. When the signs of arthritis are not prominent, the pain can be mild and only be noticed during periods of exercise." - Anonymous Online Contributor

Unverified Answer

What causes arthritis?

"Many environmental factors may have a direct or indirect influence on arthritis risk, while other factors (environmental and lifestyle factors) have a multiplicative effect on the overall effect of environmental exposure. However, evidence from multiple studies indicates a greater effect of genetics and exposure. The major environmental risk factor that has been clearly identified for rheumatoid arthritis, rheumatoid factor, does not appear to play a significant role in development of all forms of (early to late onset) psoriatic arthritis." - Anonymous Online Contributor

Unverified Answer

What is arthritis?

"We found that there is great diversity in the way arthritis is defined in the medical literature. A wide variety of terms for pain are used in the literature, and some of them do not reflect current scientific wisdom. Furthermore, the terminology used to describe the disease can be confused and is not consistent. Arthritis can be described as a medical condition in several different ways. Each description describes a subset of patients, and each description needs its own classification system. We propose that the vocabulary used to describe arthritic conditions be standardized and that such vocabulary be used in the descriptions and classifications of arthritic conditions." - Anonymous Online Contributor

Unverified Answer

Can arthritis be cured?

"The lack of correlation between the amount of pain and disease activity as determined by the RAMRIS questionnaire and the results of the Beighton scoring system means that neither pain nor the magnitude of disease activity has a demonstrable impact on disability." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in turmeric for therapeutic use?

"Turmeric was used as anti-inflammatory and antipyretic remedies many centuries ago. Its mechanism of action is largely unclear but it seems to act via two different pathways: modulation of lipid peroxidase activity and modulation of the inflammatory cascade. Its ability to inhibit the activity of some phospholipases may offer a novel anti-inflammatory mechanism; it can also be used to inhibit the activity of many other enzymes; it increases the rate of fatty acid oxidation and therefore contributes to an anti-oxidant effect by reducing lipid peroxidation; it is reported to have anti-arthritic properties. It can also suppress the production of several cytokines." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets arthritis?

"25\nanswer: Recent findings provides valuable information that may be used by the clinician for early diagnosis and appropriate management. To confirm the results, a larger study should be conducted in India. Recent findings of the present study, however, can provide baseline data with which to compare the prevalence amongst other Asian countries." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of arthritis?

"The primary cause of arthritis is idiopathic-related genofunctional imbalance. The key to treat arthritis is to maintain your functional status and optimize the quality of life by exercising, eliminating and/or consuming the secondary causes of arthritis such as pain relievers, smoking, nutritional imbalance and excess calories of energy-dense foods and drinks. You can get healthy joints by consuming your healthy joints. So by balancing these healthy practices, you can control or treat the symptoms of arthritis from the onset of symptoms such as pain to the eventual joint deformity. The more you try to prevent or treat the arthritis, the closer it will get towards remission." - Anonymous Online Contributor

Unverified Answer

How serious can arthritis be?

"Arthritis is a significant problem with major impacts upon the quality of life of those affected. The duration of a disease such as [rheumatoid arthritis](https://www.withpower.com/clinical-trials/rheumatoid-arthritis) is an important consideration, not only when managing the disease itself, but also when assessing risk factors for the development of complications. Treatment for arthritis should have the goal of remission not cure." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving turmeric?

"There were no studies found to evaluate the safety of turmeric. Although, there have been one double-blind, placebo controlled clinical trial that investigated the potential benefits of using standardized extract of turmeric. Turmeric contains curcumin, which is well-known for antifibrotic activity, and is also a p38 inhibitor and a SIRT1 activator. Turmeric may be an effective treatment for fibrosis and inflammation. However, more clinical trials are needed to determine its overall effectiveness in treating chronic inflammatory disorders." - Anonymous Online Contributor

Unverified Answer

Has turmeric proven to be more effective than a placebo?

"Oral curcumin reduced the pain and swelling of the affected joints in 90% of participants compared to a placebo. While the study showed a pain reduction of 80% and swelling reduction of 54.2% amongst the participants, the safety profile was not clear as the participants experienced an excess of serious adverse events. Recent findings of this study do not demonstrate that turmeric is an effective treatment for symptomatic psoriatic arthritis." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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