Reviewed by Michael Gill, B. Sc.
6 Lyme Disease Clinical Trials Near Me
Top Hospitals for Lyme Disease Clinical Trials
Image of Care Access Mobile Site in Connecticut.
Care Access Mobile Site
New London
1Active Trials
1All Time Trials for Lyme Disease
2022First Lyme Disease Trial
Image of Care Access Mobile Site in Connecticut.
Care Access Mobile Site
Norwich
1Active Trials
1All Time Trials for Lyme Disease
2022First Lyme Disease Trial
Top Cities for Lyme Disease Clinical Trials
Image of Stamford in Connecticut.
Stamford
3Active Trials
Stamford Health Medical GroupTop Active Site
Image of Baltimore in Maryland.
Baltimore
3Active Trials
Johns HopkinsTop Active Site
Lyme Disease Clinical Trials by Phase of Trial
Phase 1 & 2 Lyme Disease Clinical Trials
1Active Lyme Disease Clinical Trials
1Number of Unique Treatments
1Number of Active Locations
Lyme Disease Clinical Trials by Age Group
< 18 Lyme Disease Clinical Trials
1Active Lyme Disease Clinical Trials
Most Recent Lyme Disease Clinical Trials
Clinical Trial
Began Recruiting Date
Phase
8/4/2022
Phase 3
9/14/2021
Phase 1 & 2
Top Treatments for Lyme Disease Clinical Trials
Treatment Name
Active Lyme Disease Clinical Trials
All Time Trials for Lyme Disease
First Recorded Lyme Disease Trial
VLA15
2
4
2018
Tetracycline First
1
1
2022
1
1
1
2021
Teleyoga
1
1
2021
Acetaminophen
1
1
2019
Recently Completed Studies with FDA Approved Treatments for Lyme Disease
Treatment
Year
Sponsor
2217LS
2021
MassBiologics
Disulfiram
2019
Research Foundation for Mental Hygiene, Inc.

What is Lyme Disease?

Lyme disease is a vector-borne disease transmitted through black-legged tick bites infected with bacteria, such as Borrelia burgdorferi and Borrelia mayonii. The disease is prevalent in the United States, especially in the northeastern, northcentral, and mid-Atlantic areas. Once it has been transmitted, a person with Lyme disease shows symptoms of a fever, headache, fatigue, and a type of skin rash called erythema migrans. Most Lyme disease cases can be treated by antibiotics over a few weeks.

Why is Lyme Disease Being Studied in Clinical Trials?

As of today, there is only one Lyme disease vaccine being developed. Clinical trials for Lyme disease clinical trials are done in order to further aid medical experts in discovering more potential cures and treatment methods. Latest treatments and findings from clinical trials may very well lead to advancing and improving the existing knowledge of other tick-borne related diseases and illnesses.

How Do Lyme Disease Clinical Trials Work?

The study entitled “Symptomatic Management of Lyme Arthritis” is an example of how Lyme disease clinical trials work. It is presently being performed in the Children’s Hospital of Pittsburgh, spearheaded by its principal investigator Desiree Neville. Clinical trials began on October 1, 2019, and are expected to be completed by December 31, 2024.

The clinical trial commenced by recruiting three hundred eligible participants. Naproxen, the primary treatment, is being used to medicate patients with Lyme disease, Lyme arthritis, or arthritis. Each participant is designated a specific treatment group–a total of four treatment groups were made. Two treatment groups were the experimental treatment group, while the other two treatment groups were the active control group. The experimental groups were assigned to receive naproxen, a non-steroidal anti-inflammatory drug (NSAID). One experimental group was tasked to take naproxen first, then acetaminophen. Acetaminophen was also assigned to one of the control groups. However, the other group acquired standard care for its treatment. All participants were given a weight-based standard dose of drugs until symptoms ceased.

What Are Some of the Breakthrough Clinical Trials Involving Lyme Disease?

2020: A study from Stanford School of Medicine found that azlocillin is an effective drug treatment against _Borrelia burgdorferi _infection in Lyme disease patients. This was significant because results show promising signs that other strains of Borrelia burgdorferi can be similarly treated in further in vitro studies.

2021: A study from Johns Hopkins Lyme Disease Research Center found that individuals with Lyme disease can be distinguished from COVID-19 patients and the control group. This was significant because all cases showed that gene expression characteristics implied enduring effects of immunity.

Who Are The Key Opinion Leaders On Lyme Disease Trial Research?

John Nathaniel Aucott, M.D. is the present director of the Johns Hopkins Lyme Disease Clinical Research Center in Brooklandville, Maryland. He is also an associate professor of medicine at Johns Hopkins University. Dr. Aucott has over fifteen years of experience in Lyme disease research, accumulating a number of esteemed accolades along the way.

Jayakumar Rajadas, Ph. D. is a director of the Advanced Drug Delivery and Regenerative Biomaterials Laboratory in Stanford Cardiovascular Institute, which is based in Stanford, California. He is also an assistant professor of Pulmonary, Allergy and Critical Care Medicine in Stanford University School of Medicine. Today, Dr. Rajadas is the recipient of five SPARK grant awards and is a contributor to over two hundred recent journal publications.

Top Hospitals for Lyme Disease Clinical Trials

We took a look at the top hospital performing Lyme disease clinical trials. We found that it is Frontier Clinical Research, LLC, in Scottdale, Pennsylvania. Frontier Clinical Research, LLC is a site management organization that has conducted numerous clinical trials offering leading-edge medical treatments. Its medical studies are being led by two clinical research teams. One is based in Pennsylvania, while the other is in West Virginia. The hospital has one active trial at present; it is its very first Lyme disease trial to be recorded. Other top hospitals for Lyme disease clinical trials include Stamford Health Medical Group, Care Access Mobile Site in Grove City and New London, and Care Access - Hoboken.

Top Treatments for Lyme Disease Clinical Trials

We took a look at the top treatment being used in Lyme disease clinical trials. We found that 6-valent OspA-based Lyme disease vaccine (VLA15) is the chief treatment applied in most trials. Since 2018, a total of four all-time trials have been performed using the vaccine. Today, the treatment is being tested in two active clinical trials. Aside from VLA15, other top treatments for Lyme disease clinical trials include psilocybin, 1, tele-yoga, and naproxen.

Top Cities for Lyme Disease Clinical Trials

We took a look at the top city where Lyme disease clinical trials are usually being done. Stamford, located in Connecticut, surpasses other cities like Sayre, Warwick, Providence, and Erie for having the most number of trials. Its top active site for Lyme disease clinical trials is Stamford Health Medical Group, where three active clinical trials are currently in process.

Which phases are most popular for Lyme disease clinical trials?

We took a look at the most popular phase for Lyme disease clinical trials. We found that Phase 3 is the foremost phase, which is being undertaken in two active clinical trials to date. Phase 3 is active in thirty-one different locations. Other popular phases for Lyme disease clinical trials include Phase 1, Phase 1 and 2, and Phase 2.

How many Lyme disease clinical trials are open to youth and/or seniors?

We took a look at the number of Lyme disease clinical trials open to youth and/or senior participants. We found that there are six available active Lyme disease clinical trials, but only those of eligible age are able to partake in the study. The clinical trials are divided into three age groups: one for eighteen and below, one for eighteen and over, and one for participants of any age.

Most Recent Lyme Disease Clinical Trials

We took a look at the most recent Lyme disease clinical trial. We found that the study entitled “A Phase 3, Multicenter, Placebo-Controlled, Randomized, Observer-Blinded Trial to Evaluate the Efficacy, Safety, Tolerability, Immunogenicity, and Lot Consistency of a 6-Valent OspA-Based Lyme Disease Vaccine in Healthy Participants ≥5 Years of Age” is the latest among several clinical trials. The clinical trial began its recruitment on September 4, 2022, and it is estimated to be completed on December 31, 2024.

References:

https://www.cdc.gov/lyme/index.html#:~:text=Lyme%20disease%20is%20caused%20by,skin%20rash%20called%20erythema%20migrans.

https://www.cdc.gov/lyme/transmission/index.html

https://www.globallymealliance.org/lyme-patient-support/clinical-trials/

https://clinicaltrials.gov/ct2/show/NCT04038346

https://www.withpower.com/trial/phase-3-lyme-disease-9-2019-ebfe4#summary

https://www.nature.com/articles/s41598-020-59600-4#Sec9

https://pubmed.ncbi.nlm.nih.gov/33763080/

https://www.hopkinsmedicine.org/profiles/details/john-aucott.

https://med.stanford.edu/bioadd/people/jayakumar-rajadas.html

https://frontierclinical.com/

https://clinicaltrials.gov/ct2/show/NCT05477524

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 15th, 2021

Last Reviewed: October 8th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

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