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What Are Celiac-Disease Clinical Trials?
Celiac disease is a disease that involves an immune reaction to eating gluten. As a result, those with celiac disease often suffer from various symptoms, including fatigue, weight loss, bloating, and malabsorption of vitamins and minerals.
Over time celiac disease can have severe complications, and the immune reaction to gluten can damage the small intestine.
According to Mayo Clinic, there is currently no cure for those with celiac disease, but patients can reduce symptoms by following a strict gluten-free diet.
Because there is no cure for celiac disease, clinical trials must be conducted to help those diagnosed with this condition.
Why Is Celiac Disease Being Studied Through Clinical Trials?
Currently, celiac disease cannot be cured, and those diagnosed can only eliminate gluten from their diet to help alleviate symptoms. Despite this, many celiac sufferers mistakenly ingest gluten or ingest food that has been cross-contaminated with gluten, which causes further organ damage to the small intestine.
It’s imperative that clinical trials are conducted to ease symptoms in those who have celiac disease and help improve their intestinal health.
Most people with celiac disease remain undiagnosed, but the NIH and experts estimate that 2 million people in the United States suffer from celiac disease.
What Are The Types Of Treatments Available For Celiac Disease?
There are currently no treatments for celiac disease besides following a strict gluten-free diet. However, in terms of clinical trials and research, there are a few treatments in the trial phases which could be used to treat celiac disease. These include:
What Are Some Recent Breakthrough Clinical Trials For Celiac Disease?
2021: ZED 1227 for the treatment of celiac disease – Dr. Detlef Shuppan has developed a new drug to treat gluten intolerance and celiac disease called ZED 1227. This may be the first and only effective treatment option for celiacs and is one of the only treatments where efficacy has been established.
2022: KAN - 101 – The drug KAN – 101 focuses on restoring the immune system's tolerance to gluten by targeting receptors in the liver. This clinical trial showed promising results after the first phase of testing and has been proven safe and well tolerated by the participants involved in the clinical trial.
Who Are Some Of The Key Opinion Leaders / Researchers In Celiac-Disease Clinical Trials?
Benjamin Lebwohl is the director at the Celiac Disease Center at Columbia University. Lebwohl and other researchers at the Celiac Disease Center have ongoing clinical research programs and trials for the treatment of celiac disease.
Dr. Alessio Fasano is the director at the Center for Celiac Research at Massachusetts General Hospital. Dr. Fasano is currently leading research projects in gastrointestinal microbiota and environmental factors to establish why some people are predisposed to celiac disease.