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Breast Cancer Clinical Trials
Breast Cancer studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect breast cancer clinical trial.
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Omit breast radiation
Los Angeles, CA
18+
Female
Waitlist Available
Metastatic
Los Angeles, CA
18+
Female
The purpose of this study is to evaluate the feasibility, based on recruitment rate over a 3-year period, of enrolling patients for the omission of post-operative breast radiation following breast conserving surgery and sentinel node biopsy or axillary lymph node dissection in women with H…
Wee1 Inhibitor ZN-c3
Portland, OR
18+
All Sexes
Phase < 1
Waitlist Available
Grade I
Portland, OR
18+
All Sexes
This early phase I trial tests the safety and side effects of ZN-c3 in treating patients with triple-negative breast cancer or ovarian cancer that have spread to other parts of the body (metastatic or advanced). ZN-c3 is an enzyme inhibitor that may stop the growth of cancer cells by block…
[225Ac]-FPI-1966
Duarte, CA
18+
All Sexes
Phase 1 & 2
Recruiting
Locally Advanced
Duarte, CA
18+
All Sexes
This is a first-in-human, Phase 1/2, non-randomized, multi-centre, open-label clinical study designed to investigate safety, tolerability, dosimetry, biodistribution, and PK of [225Ac] FPI-1966, [111In]-FPI-1967, and vofatamab and the preliminary anti-tumour activity of [225Ac]-FPI-1966 in…
Audiovisual Intervention- Cancer Clinical Trials Education
New York, NY
18+
All Sexes
Waitlist Available
New York, NY
18+
All Sexes
The study aims to develop educational media interventions to prepare Latinx Spanish-speaking radiation oncology patients for a course of breast or prostate cancer radiation therapy and to foster receptivity and informed decision-making around cancer clinical trial participation.
Digital Health Coaching Program
Omaha, NE
18+
All Sexes
Waitlist Available
Omaha, NE
18+
All Sexes
This study intends to explore feasibility, acceptability, and outcomes related to the use of a digital health coaching intervention for individuals who have completed primary therapy for cancer. Up to 500 individuals with diverse cancer diagnoses will be enrolled across up to 5 clinical si…
Petrolatum-Mineral Oil-Lanolin-Ceresin Ointment
Duarte, CA
18+
Female
Phase 1
Waitlist Available
Duarte, CA
18+
Female
This clinical trial compares two supplemental topical agents (Aquaphor and Miaderm) for the treatment of acute radiation dermatitis in patients with breast cancer undergoing radiation therapy. Radiation dermatitis is a radiation-induced skin reaction which can cause itching, swelling, pain…
Negative Pressure Wound Therapy
London, Canada
18+
Female
Waitlist Available
London, Canada
18+
Female
The current study is a single center randomized control trial that will examine the effect of closed incision negative pressure wound therapy (ciNPT) versus conventional dressing on abdominal incision in a deep inferior epigastric perforator (DIEP) flap based reconstruction. Patients will …
Imagio OA/US
Dallas, TX
18+
All Sexes
Recruiting
Locally Advanced
Dallas, TX
18+
All Sexes
This is an early research and development study. The objective of this study is to determine the feasibility of the Imagio OA/US Breast Imaging System to detect complete breast cancer pathologic response to neoadjuvant therapy as assessed by functional optoacoustic features, vascular featu…
SIS TALK Back Intervention
Washington, United States
18+
Female
Recruiting
Stage I
Washington, United States
18+
Female
The purpose of this study is to test an evidence-based intervention designed to increase adherence to systemic therapy in Black women compared to enhanced usual care.
Chemotherapy
Philadelphia, PA
18+
All Sexes
Phase 2
Waitlist Available
Grade III
Philadelphia, PA
18+
All Sexes
This phase II trial studies whether intermittent fasting works to improve outcomes in patients with stage I-III breast cancer receiving chemotherapy before surgery (neoadjuvant) with a body mass index >= 25. Intermittent fasting has been shown to elicit similar metabolic changes as calorie…
Unsupervised Home-Based Exercise
Boston, MA
18+
All Sexes
Waitlist Available
Stage I
Boston, MA
18+
All Sexes
The purpose of this research is to determine whether a 16 week, home-based, aerobic and resistance exercise intervention will increase physical activity levels in Black and Hispanic breast, colorectal, or prostate cancer patients. The names of the study interventions involved in this stud…
Juzo Compression Sleeve and Glove
Boston, MA
18+
Female
Waitlist Available
High Risk
Boston, MA
18+
Female
This research study is a Pilot Study examining the use of a compression sleeve with embedded sensor to prevent lymphedema.
Paclitaxel
Tampa, FL
18+
All Sexes
Phase 2
Recruiting
Stage I
Tampa, FL
18+
All Sexes
The purpose of the study is to find out if an investigational drug called Dendritic Cell (DC1) vaccine added to standard neoadjuvant (given before main treatment) therapy can help people with HER2 (human epidermal growth factor receptor 2) positive breast cancer.
Educational Intervention
Columbus, OH
18 - 65
Female
Waitlist Available
High Risk
Columbus, OH
18 - 65
Female
This stage I clinical trial compares a genetic counseling patient preference (GCPP) intervention via EHR MyChart patient portal to conventional genetic counseling for women at elevated risk for breast cancer. Women at elevated breast cancer risk may be offered genetic counseling and geneti…
OPTIMISE
Houston, TX
18+
All Sexes
Recruiting
High Risk
Houston, TX
18+
All Sexes
Cancer survivors have unique healthcare needs including risk for serious late effects, ongoing surveillance, lifestyle modifications to reduce second cancer risk, and psychosocial support. Nearly 70% have at least one comorbid chronic condition in addition to cancer. Comorbidities pose sig…
Trastuzumab
Los Angeles, CA
18+
All Sexes
Phase 1 & 2
Recruiting
Locally Advanced
Los Angeles, CA
18+
All Sexes
This phase Ib/II trial studies the side effects and best dose of ribociclib, tucatinib, and trastuzumab for the treatment of HER2 positive breast cancer that has spread to other parts of the body (metastatic), and then compares the effect of ribociclib, tucatinib, trastuzumab with or witho…
Pembrolizumab
Duarte, CA
18+
All Sexes
Phase 2
Waitlist Available
Grade II
Duarte, CA
18+
All Sexes
This phase II trial studies the side effects and best dose of ivermectin in combination with pembrolizumab and to see how well they they work in shrinking tumors in patients with triple negative breast cancer that has spread to other places in the body (metastatic). Immunotherapy with mono…
Prepectoral Breast Reconstruction without Acellular Dermal Matrix (ADM)
New York, NY
18 - 65
Female
Phase 3
Recruiting
New York, NY
18 - 65
Female
The researchers are doing this study to look at the number of complications that occur immediately after prepectoral breast reconstruction when Acellular Dermal Matrix (ADM) is used compared to when ADM is not used. These complications include infections, the need for Tissue Expander (TE) …
Systemic Therapy
Atlanta, GA
18+
All Sexes
Phase 2
Waitlist Available
Metastatic
Atlanta, GA
18+
All Sexes
This phase II trial studies the effects of radioembolization with yttrium Y-90 works as a 2nd or 3rd line therapy for treating patients with breast cancer that has spread to the liver (metastatic to the liver). Yttrium Y-90 radioembolization is a therapy that injects radioactive particles …
Opt-out scheduling
Seattle, WA
18+
Female
Waitlist Available
Seattle, WA
18+
Female
This is a randomized controlled trial that will evaluate the effectiveness two different outreach strategies for a population-based breast cancer screening program at the VA Puget Sound among average risk female Veterans who are due for breast cancer screening.
Pencil Beam Scanning Proton Therapy
New York, NY
18+
All Sexes
Recruiting
New York, NY
18+
All Sexes
The goal of this clinical research trial is to study the use of differing investigational doses and scheduling for Proton Therapy for tumors previously treated with radiation therapy. Generally, when patients are first treated for cancer with radiation therapy, they are treated with tradit…
NGM438
Grand Rapids, MI
18+
All Sexes
Phase 1
Recruiting
Grade I
Grand Rapids, MI
18+
All Sexes
Study of NGM438 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumors
Quality of Life Survey
Winston-Salem, NC
18 - 65
Female
Phase < 1
Waitlist Available
Grade I
Winston-Salem, NC
18 - 65
Female
The purpose of this research study is to understand what effect near complete estrogen deprivation (NCED) therapy has on the heart in breast cancer patients. Investigators want to understand if NCED changes how the heart works.
Fulvestrant Run-In
Houston, TX
18+
Female
Phase 2
Recruiting
Grade II
Houston, TX
18+
Female
The study will investigate if a one month drug holiday from the CDK4/6 inhibitor drug, abemaciclib, will restore the body's sensitivity to the drug and make the subsequent treatment of abemaciclib plus fulvestrant more effective.
QBS72S
Palo Alto, CA
18+
All Sexes
Phase 2
Waitlist Available
Grade I
Palo Alto, CA
18+
All Sexes
This study will evaluate whether the chemotherapy agent QBS10072S,a.k.a. QBS72S, is effective and safe as a treatment for two types of brain metastases from triple negative breast cancer.
RGT-419B in combination with hormonal therapy
Port Saint Lucie, FL
18+
All Sexes
Phase 1
Recruiting
Locally Advanced
Port Saint Lucie, FL
18+
All Sexes
This is a phase I, First-in-Human (FIH), open-label study to evaluate the safety, tolerability, pharmacokinetic (PK) profile, and preliminary efficacy of RGT-419B administered orally as monotherapy OR in combination with Hormonal Therapy in subjects with HR+, HER2- locally advanced and unr…
Faith in Action! Church-based Navigation Model
Los Angeles, CA
18+
Female
Waitlist Available
Los Angeles, CA
18+
Female
The purpose of this research is to develop a culturally adapted "Faith in Action!" curriculum to train lay health navigators to provide breast cancer screening navigation to Korean American women within faith-based settings and evaluate whether the culturally adapted "Faith in Action!" cur…
ZetaFuse™ Bone Graft
Montréal, Canada
18+
Female
Waitlist Available
Metastatic
Montréal, Canada
18+
Female
The ZetaFuse™ Bone Graft is indicated for patients with destructive, lytic lesions due to oligometastatic cancer (≤5 metastatic lesions located at ≤3 tissue sites), with at least one metastatic lesion located in a vertebral body of the spine, and a Spinal Instability Neoplastic Score (SINS…
Constructive Shearwave Interference (CSI)
Durham, NC
18+
All Sexes
Waitlist Available
Durham, NC
18+
All Sexes
This proof of concept study will evaluate the ability of a new, ultrasound based technology called Bullseye Constructive Shearwave Interference (CSI) (trade name, Bullseye Elasticity Quantification) to measure lymphedema of the upper arm among breast cancer survivors. The study's hypothes…
Equity Dashboard and Community Health Worker Support
Boston, MA
18+
All Sexes
Recruiting
Boston, MA
18+
All Sexes
In this project, the impact of providing a practice-level equity dashboard that displays ambulatory quality outcome metrics stratified by race and language to primary care providers at Massachusetts General Hospital (MGH) will be evaluated. Provision of the dashboard data will be paired wi…
Social Contact Reminder
Saint Louis, MO
18+
Female
Recruiting
Locally Advanced
Saint Louis, MO
18+
Female
Eliminating racial disparities in breast cancer is a top public health priority. African American (AA) women often present with more advanced and aggressive disease at the time of diagnosis and are more likely to die from breast cancer than any other racial/ethnic group in the United State…
LYL797
Philadelphia, PA
18+
All Sexes
Phase 1
Recruiting
Locally Advanced
Philadelphia, PA
18+
All Sexes
This study will evaluate the safety and tolerability of LYL797, a ROR1-targeted CAR T-cell therapy, in patients with ROR1+ relapsed or refractory triple negative breast cancer (TNBC) or non-small cell lung cancer (NSCLC). The first part of the study will determine the safe dose for the nex…
Sargramostim
Jacksonville, FL
18+
All Sexes
Phase 1
Recruiting
Locally Advanced
Jacksonville, FL
18+
All Sexes
This phase I trial tests the safety and tolerability of an experimental personalized vaccine when given by itself and with pembrolizumab in treating patients with solid tumor cancers that have spread to other places in the body (advanced). The experimental vaccine is designed target certai…
Dermaprazole 2%
Houston, TX
18+
All Sexes
Phase 1 & 2
Waitlist Available
Grade II
Houston, TX
18+
All Sexes
Radiotherapy is a mainstay of treatment in head and neck cancer and breast cancer treatment, typically following surgery and/or chemotherapy. Radiation dermatitis, which involves redness, dryness, and/or peeling of the skin, occurs in up to 95% of patients receiving radiation therapy. Ther…
Low AGE diet
Saint Louis, MO
18+
Female
Waitlist Available
Locally Advanced
Saint Louis, MO
18+
Female
The scientific premise for this study is the known impact of overweight/obesity on breast cancer risk and outcomes, the association between advanced glycation end-products (AGE) and high fat, highly processed foods common in Western diets, and the preclinical evidence suggesting a link bet…
PF-07104091 + PF-07220060 + letrozole dose expansion
Grand Rapids, MI
18+
All Sexes
Phase 2
Recruiting
Locally Advanced
Grand Rapids, MI
18+
All Sexes
To assess the safety and tolerability of increasing doses of PF-07220060 in combination with PF-07104091 and to estimate the Maximum Tolerated Dose (MTD) and/or select the Recommended dose for expansion (RDE) for PF-07220060 in combination with PF-07104091 in participants with breast cance…
DAN-222
Nashville, TN
18+
Female
Phase 1
Recruiting
Metastatic
Nashville, TN
18+
Female
This is an open-label, multicenter, dose-escalation study designed to assess the safety, tolerability, and PK of IV administered DAN-222 followed by a dose-escalation of DAN-222 in combination with niraparib. There are two stages within this study: Stage 1: Part A is dose escalation of s…
Behavioral: Sit Less
La Jolla, CA
18+
Female
Recruiting
La Jolla, CA
18+
Female
This 3-month study will test whether a program to reduce sitting time, for breast cancer survivors experiencing some physical limitations, can improve their physical function and other important aspects of quality of life.
ddAC/ddT
Washington, United States
18+
Female
Phase 1 & 2
Waitlist Available
Metastatic
Washington, United States
18+
Female
This is a pilot study to evaluate the safety and tolerability of azeliragon when administered with chemotherapy. The Investigators hypothesize that there will be no significant interaction with Azeliragon and chemotherapy.
general exercise
Edmonton, Canada
18+
Female
Waitlist Available
Stage I
Edmonton, Canada
18+
Female
The primary purpose of this study is to determine the feasibility of our proposed intervention approach involving (1) an integrated physiotherapy and exercise intervention for individuals with breast cancer who are undergoing chemotherapy and (2) delivery of programming via an electronic h…
Ribociclib
Boston, MA
18+
All Sexes
Phase 1 & 2
Recruiting
Locally Advanced
Boston, MA
18+
All Sexes
This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and anticancer activity of BLU-222, a selective inhibitor of CDK2.
NUV-868
Huntersville, NC
18+
All Sexes
Phase 1 & 2
Recruiting
Locally Advanced
Huntersville, NC
18+
All Sexes
NUV-868-01 is a first-in-human, open-label, Phase 1/2 dose escalation and expansion study in patients with advanced solid tumors. The Phase 1 and 1b portions include patients with advanced solid tumors and are designed to determine the safety and the dose of NUV-868 to be used as monothera…
Fulvestrant
Columbus, OH
18+
All Sexes
Phase 1 & 2
Waitlist Available
Locally Advanced
Columbus, OH
18+
All Sexes
The purpose of this study is to test the safety of an investigational drug called CFI-402257 alone in advanced solid tumors and in combination with Fulvestrant in advanced breast cancer patients.
da Vinci SP Surgical System
Dallas, TX
18+
Female
Recruiting
High Risk
Dallas, TX
18+
Female
This is a single arm, single-center, prospective clinical trial designed to track the peri, post-operative and oncologic outcomes when utilizing the da-Vinci single port (SP) robotic platform to perform robotic nipple sparing mastectomy (rNSM) and immediate breast reconstruction with tissu…
Biopsy
Duarte, CA
18+
All Sexes
Waitlist Available
Locally Advanced
Duarte, CA
18+
All Sexes
This clinical trial attempts to understand the differences between two chemotherapy drugs, ribociclib and palbociclib, and how they fight cancer. This study looks at tissue and blood characteristics of patients receiving these therapies in the hopes to develop a way to predict which medica…
Capmatinib
Houston, TX
18+
All Sexes
Phase 1 & 2
Waitlist Available
Grade I
Houston, TX
18+
All Sexes
This study is to learn if the combination therapy of capmatinib and neritinib can help to control metastatic or locally advanced breast cancer. Researchers also want to find the highest tolerable dose of the combination therapy of capmatinib and neritinib that can be used in this study dru…
Questionnaire Administration
Columbus, OH
18 - 65
Female
Waitlist Available
Stage I
Columbus, OH
18 - 65
Female
This clinical trial studies the use of a quality of life intervention called Y-AMBIENT to help young African American with stage I-III breast cancer manage daily life. Y-AMBIENT is a four-month, telephone-based intervention that includes three themed education sessions with three follow-up…
Rimiducid
San Antonio, TX
18+
All Sexes
Phase 1
Recruiting
Locally Advanced
San Antonio, TX
18+
All Sexes
A Phase 1, open label, dose escalation and expanded cohort study of P-MUC1C-ALLO1 in adult subjects with advanced or metastatic epithelial derived solid tumors, including but not limited to the tumor types listed below.
Alectinib
Portland, OR
18+
All Sexes
Phase 2
Waitlist Available
Grade I
Portland, OR
18+
All Sexes
This phase II trial determines if testing samples from a patients' cancer can be used to find specific drugs or drug combinations that can help control their disease. The safety and tolerability of the drug or drug combination is also to be studied. Another purpose is for researchers to st…
Faster Asleep Smart Speaker Program
Washington, United States
18+
Female
Recruiting
Stage I
Washington, United States
18+
Female
The aim of this study is to determine the impact of the voice-activated smart speaker CBT-I components on insomnia symptoms among breast cancer survivors using a randomized clinical trial.
Pembrolizumab
Aurora, CO
18+
All Sexes
Phase 2
Recruiting
Grade I
Aurora, CO
18+
All Sexes
Patients with locally advanced unresectable or metastatic programmed cell death ligand (PD-L1) positive triple negative breast cancer (TNBC) will be treated with radiation to one-four sites of metastasis amenable to radiation (sites of disease to be selected at the discretion of the treati…
GLSI-100
Houston, TX
18+
All Sexes
Phase 3
Waitlist Available
High Risk
Houston, TX
18+
All Sexes
This is a prospective, randomized, double-blinded, placebo-controlled, multi-center, Phase 3 study of GLSI-100 immunotherapy in HLA-A*02 positive and HER2/neu positive subjects who are at high risk for disease recurrence and have completed both neoadjuvant and postoperative adjuvant standa…
Tucatinib
Madison, WI
18+
All Sexes
Phase 1 & 2
Waitlist Available
Locally Advanced
Madison, WI
18+
All Sexes
Phase IB/II clinical trial of Alpelisb and Tucatinib in patients with PIK3CA-Mutant HER2-positive metastatic breast cancer.
Computed Tomography
Houston, TX
18+
All Sexes
Phase 2
Waitlist Available
Houston, TX
18+
All Sexes
This phase II trial tests whether [18F]FluorThanatrace by positron emission tomography (PET)/computed tomography (CT) can improve imaging techniques in patients with breast cancer undergoing a standard of care biopsy or surgery. [18F]FluorThanatrace is a new radioactive tracer, which is a …
Cognitive Behavioral Therapy for Insomnia
Philadelphia, PA
18+
Female
Waitlist Available
1 Prior Treatment
Philadelphia, PA
18+
Female
Cancer-related fatigue (CRF) and insomnia are prevalent among cancer patients and have been linked to de-creases in quality of life and poorer overall survivorship. Currently, the mechanisms underlying CRF are not well understood, which has led to treatments that are only moderately effect…
Genetic Counseling
Boston, MA
18+
All Sexes
Waitlist Available
Boston, MA
18+
All Sexes
The overall study objective of this trial study is to identify and evaluate strategies to improve the accessibility of the video education with result dependent disclosure (VERDI) model, increasingly utilized as a pre-genetic testing (pretest) education alternative in clinical practice, to…
Harmonic motion imaging guided focused ultrasound (HMIgFUS)
New York, NY
18+
Female
Recruiting
Metastatic
New York, NY
18+
Female
The objective of this study is to demonstrate the initial clinical feasibility of using Harmonic Motion Imaging (HMI) for Focused Ultrasound Surgery (FUS) guidance and monitoring in patients with benign and stage 1 non-metastatic breast cancers. The investigators hypothesize that changes i…
Radiation: Single Pre-Operative Radiation Therapy
Montreal, Canada
18+
Female
Phase 2
Recruiting
Montreal, Canada
18+
Female
Eligible women will receive neoadjuvant single fraction radiotherapy followed by surgery performed after one year
Fulvestrant
Boston, MA
18+
All Sexes
Phase 1
Recruiting
Locally Advanced
Boston, MA
18+
All Sexes
This is an open-label, FIH study designed to evaluate the maximum tolerated dose, safety, tolerability, PK, pharmacodynamics, and preliminary antineoplastic activity of RLY-2608, in advanced solid tumor patients with a Phosphatidylinositol-4,5-bisphosphate-3 kinase, catalytic subunit alpha…
Questionnaire Administration
Columbus, OH
18+
All Sexes
Recruiting
Metastatic
Columbus, OH
18+
All Sexes
This clinical trial tests whether a video intervention improves patient understanding of tumor genomic testing in patients with cancer that has spread to other parts of the body (metastatic). Measuring how the video intervention affects patient understanding of tumor genomic testing in pat…
NGM831 plus pembrolizumab
Austin, TX
18+
All Sexes
Phase 1
Recruiting
Grade I
Austin, TX
18+
All Sexes
Study of NGM831 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumors
Reparixin
Saint Petersburg, FL
18+
All Sexes
Phase 2
Locally Advanced
Saint Petersburg, FL
18+
All Sexes
Primary objective: • To assess the efficacy of reparixin compared to placebo in limiting CRF in adult patients with locally advanced or metastatic breast cancer undergoing single-agent taxane chemotherapy, using FACITFatigue scale. The secondary objectives are: To evaluate change in Qua…
Iodinated Contrast Media (ICM)
Pittsburgh, PA
18+
Female
Phase 4
Recruiting
Pittsburgh, PA
18+
Female
One of the primary criticisms of mammography is that it leads to unneeded stress and anxiety from identification and biopsy of non-cancerous findings. Contrast-enhanced mammography (CEM) has the potential to significantly reduce biopsy rates for commonly seen benign breast lesions while pr…
Pembrolizumab
Uniondale, NY
18+
All Sexes
Phase 2
Recruiting
Newly Diagnosed
Uniondale, NY
18+
All Sexes
This study will test any good and bad effects of combining the study drugs pembrolizumab and olaparib, given before the standard surgical procedure, to treat TNBC or HR+ HER2- breast cancers. The study drugs could shrink cancer, but they could also cause side effects. The study researchers…
Dasatinib
Houston, TX
18+
All Sexes
Phase 1 & 2
Recruiting
Class II
Houston, TX
18+
All Sexes
This phase Ib/II tests the safety, side effects, and best dose of icosapent ethyl in combination with dasatinib and whether they work to shrink tumors in patients with triple-negative inflammatory breast cancer that has spread to other places in the body (metastatic). Triple-negative infla…
SGN-B7H4V
Denver, CO
18+
All Sexes
Phase 1
Recruiting
Locally Advanced
Denver, CO
18+
All Sexes
This study will test the safety of a drug called SGN-B7H4V in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to the body besides treating the disease. Participants will have cancer that has spread in the body near wh…
Inspiratory muscle training
Columbus, OH
18+
Female
Waitlist Available
Columbus, OH
18+
Female
The investigators propose a randomized controlled trial to determine the effectiveness of inspiratory muscle training in stage 0-III obese breast cancer survivors. The investigators central hypothesis is that obesity promotes exercise intolerance via obesity-related impaired breathing mech…
NUV-422
Canton, OH
18+
All Sexes
Phase 1 & 2
Recruiting
Locally Advanced
Canton, OH
18+
All Sexes
NUV-422-03 is a randomized, non-comparative Phase 1/2 dose escalation and expansion study designed to evaluate the safety and efficacy of NUV-422 in combination with fulvestrant relative to NUV-422 monotherapy and fulvestrant monotherapy. The study population is comprised of adults with HR…
Oleogel-S10
Harrison, NY
18+
All Sexes
Phase 2
Recruiting
Grade II
Harrison, NY
18+
All Sexes
The purpose of this study is find out whether Oleogel-S10 is an effective treatment for radiation dermatitis when it is used in combination with a standard wound treatment cream called triamcinolone. Oleogel-S10 has shortened the healing time for other types of skin wounds such as burns. T…
Biospecimen Collection
Seattle, WA
18+
Female
Phase 4
Recruiting
Stage I
Seattle, WA
18+
Female
This stage IV trial examines how a mutation in HSD3B1 (1245C) gene affects treatment of stage I-III breast cancer. This trial may help researchers determine if mutations in HSD3B1 decreases the efficacy of aromatase inhibitor therapy such as letrozole. Letrozole may stop the growth of canc…
Paclitaxel
Ann Arbor, MI
18+
Female
Phase 4
Recruiting
Stage I
Ann Arbor, MI
18+
Female
The primary objective of this pharmacokinetics study is to compare the maximum concentration level of paclitaxel in patients with low/sarcopenic skeletal muscle area (SMA), at the end of a 2-3 hour paclitaxel infusion, to the maximum level in patients with normal SMA at the end of a standa…
Yoga Intervention
Toronto, Canada
18+
All Sexes
Recruiting
Stage I
Toronto, Canada
18+
All Sexes
The purpose of this pilot study is to assess the feasibility of a remotely-delivered yoga intervention for breast cancer survivors.
Cyclophosphamide
Houston, TX
18+
All Sexes
Phase 2
Waitlist Available
Metastatic
Houston, TX
18+
All Sexes
This phase II trial tests whether panitumumab and pembrolizumab in combination with standard of care chemotherapy before surgery (neoadjuvant) works to shrink tumors in patients with stage III-IV triple negative breast cancer. Panitumumab is a monoclonal antibody that may interfere with th…
CBCT Imaging
Halifax, Canada
18+
All Sexes
Waitlist Available
Halifax, Canada
18+
All Sexes
This is a feasibility study investigating the image quality of a new, high-performance cone beam CT (CBCT) used for on-couch imaging during radiotherapy treatments.
Gamification and Social Support
Duarte, CA
18+
All Sexes
Recruiting
High Risk
Duarte, CA
18+
All Sexes
This is a two-arm, randomized, controlled trial to evaluate the effectiveness of using a behaviorally designed gamification intervention with social support compared to an attention control group to increase physical activity during a 6-month intervention with a 3-month follow-up period. W…
You-Tube Video: Elissa's EE song
Richmond, VA
18+
Female
Recruiting
Richmond, VA
18+
Female
This clinical trial aims to test if Elissa's Entertainment-Education (EE) song can influence Saudi females' intention to perform breast cancer early screening via mammogram.
Fulvestrant
Phoenix, AZ
18+
All Sexes
Phase 3
Recruiting
Locally Advanced
Phoenix, AZ
18+
All Sexes
This study will evaluate the effect of adding abemaciclib to fulvestrant for the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer that progressed or recurred after previous treatment with a type of drug known as a CDK4/6 …
Niraparib
Sioux Falls, SD
18+
All Sexes
Phase 2
Recruiting
Locally Advanced
Sioux Falls, SD
18+
All Sexes
The purpose of this study is to further evaluate the efficacy and safety of niraparib in patients with locally advanced or metastatic solid tumors and a pathogenic or likely pathogenic tumor PALB2 (tPALB2) mutation.