This trial is testing chemotherapy drugs and an antibody before surgery in patients with stage II-III breast cancer to see if it kills more tumor cells. Tissue samples will be collected to study how patients respond to treatment.
- Stage IIB Breast Cancer
- Stage IIIA Breast Cancer
- Stage IIA Breast Cancer
- Breast Cancer, Stage IIIB
- Breast Cancer Stage IIIc
- Breast Cancer Stage IV
1 Primary · 1 Secondary · Reporting Duration: Baseline to 6 months
Side Effects for
Awards & Highlights
3 Treatment Groups
Stratum A (HER2-positive disease)
1 of 3
Stratum B (paclitaxel followed by AC)
1 of 3
Stratum C (AC followed by paclitaxel)
1 of 3
132 Total Participants · 3 Treatment Groups
Primary Treatment: Paclitaxel · No Placebo Group · N/A
Who is running the clinical trial?
Age 18+ · All Participants · 0 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
- Karagiannis, George S., Jessica M. Pastoriza, Yarong Wang, Allison S. Harney, David Entenberg, Jeanine Pignatelli, Ved P. Sharma, et al.. 2017. “Neoadjuvant Chemotherapy Induces Breast Cancer Metastasis Through a Tmem-mediated Mechanism”. Science Translational Medicine. American Association for the Advancement of Science (AAAS). doi:10.1126/scitranslmed.aan0026.
- Karagiannis GS, Pastoriza JM, Wang Y, Harney AS, Entenberg D, Pignatelli J, Sharma VP, Xue EA, Cheng E, D'Alfonso TM, Jones JG, Anampa J, Rohan TE, Sparano JA, Condeelis JS, Oktay MH. Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism. Sci Transl Med. 2017 Jul 5;9(397):eaan0026. doi: 10.1126/scitranslmed.aan0026. Erratum In: Sci Transl Med. 2017 Jul 19;9(399):
- Jesus D. Anampa Mesias 2013. "Chemotherapy Before Surgery and Tissue Sample Collection in Patients With Stage IIA-IIIC Breast Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01897441.
Frequently Asked Questions
What is the cap on participants for this medical trial?
"This medical trial is currently not open to participants. It was originally published on June 1st, 2013 and the most recent edit occurred August 11th 2022. If you are looking for other studies, 2293 trials recruiting patients with stage iia breast cancer and 1825 clinical tests searching for Paclitaxel volunteers are available." - Anonymous Online Contributor
Is this experiment pioneering a new avenue of research?
"Globally, 1825 trials investigating Paclitaxel are in progress across 3709 cities and 82 nations. This therapeutic agent was originally tested by Alfacell back in 1997 when 300 participants were enrolled for a Phase 3 evaluation. Since then, 3138 assessments have been finished." - Anonymous Online Contributor
Has Paclitaxel been the focus of any previous medical investigations?
"Currently, 1825 studies are being conducted that research Paclitaxel of which 410 have entered Phase 3. Though the majority of these trials occur in Seattle, Washington, there are almost 78 thousand locations involved worldwide." - Anonymous Online Contributor
To what ailments is Paclitaxel commonly prescribed?
"Paclitaxel has been known to effectively treat a wide range of conditions including cyclophosphamide, kaposi's sarcoma aids related, and leukemia." - Anonymous Online Contributor
Is enrollment still open for this medical investigation?
"As per data hosted on clinicaltrials.gov, this particular research project is not presently recruiting patients. The trial was first posted in June 2013 and last updated in August 2022; however, there are over four thousand additional trials actively enrolling participants." - Anonymous Online Contributor