Endometrial Cancer Clinical Trials 2023

What Are Endometrial Cancer Clinical Trials?

Endometrial cancer clinical trials are studies that test lab findings on people suffering from the disease. The purpose is to learn more about this particular type of cancer and test the safety and efficacy of new drugs and therapies on a group of patients under varying conditions to determine whether they are fit for public use or not.

Endometrial cancer is a condition in which cancer cells grow in the uterus lining.

Why Is Endometrial Cancer Being Studied Through Clinical Trials?

Endometrial cancer is being studied through clinical trials because it is the most common type of gynecologic cancer. Among all cancers, it is the sixth most commonly occurring type in women worldwide (4th most common in American women). About 50,000 women are diagnosed with endometrial cancer every year in the United States alone. The numbers might not be as high as they are for several other types of cancers, but the prevalence of endometrial cancer has significantly increased over the years, demanding in-depth research and analyses of the underlying causes and investigations for better drugs and therapies for which clinical trials are vital.

What Are The Types of Treatments Available For Endometrial Cancer?

There are multiple treatment options available for endometrial cancer. Depending on how much cancer has progressed, treatment for a patient can include one or more of them. The available options include:

• Surgery (to remove the uterus, ovaries, and fallopian tubes)
• Chemotherapy
• Radiation Therapy
• Hormone Therapy
• Targeted Therapy
• Immunotherapy
• Palliative Care

What Are Some Recent Breakthrough Clinical Trials For Endometrial Cancer?

2023: A clinical trial showed that combining Pembrolizumab with the targeted therapy drug Lenvatinib can prevent progression and increase the overall survival rate in patients suffering from advanced endometrial cancer that is not dMMR or MSI-H. The results of the trial led to the approval of the drugs to be used together.

2023: A phase II trial found that the combination of Letrozole, which is an aromatase inhibitor drug, and Abemaciclib, a targeted drug, caused the tumors to reduce or stabilize in two-thirds (75%) of the participants who had persistent or recurrent estrogen recepter-positive endometrial cancer.

Who Are Some Of The Key Opinion Leaders / Researchers / Institutions Conducting Endometrial Cancer Clinical Trial Research?

Foundation for Women’s Cancer: The official foundation of the Society of Gynecologic Oncology (SGO), the Foundation of Women’s Cancer works to increase awareness and education and advance research for gynecologic cancers with the aim of identifying risks, early detection, and making optimal treatments more widely available and accessible.

Women’s Cancer Research Foundation: The WCRF is a non-profit research organization dedicated to investigating and assessing new treatments for breast, endometrial, ovarian, and cervical cancers.