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Carboplatin + Nab-Paclitaxel +/- Vorinostat for Breast Cancer
Study Summary
This trial is studying carboplatin and paclitaxel albumin-stabilized nanoparticle formulation with or without vorinostat in treating patients with breast cancer.
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Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I haven't had any cancer except for skin cancer in the last 5 years.I am currently taking medication that affects cell DNA.I am not taking any experimental drugs.I have a history of cancer.My menopausal status is not relevant.I am currently receiving or have received systemic treatment for my cancer.I am not currently undergoing any chemotherapy, hormone therapy, radiation, or experimental treatments.I am currently on a biological therapy.My breast cancer is of the infiltrating lobular type.I have had a condition where my lymphocytes grow abnormally.My kidney function is reduced with a creatinine clearance below 50 mL/min.I have moderate to severe numbness, tingling, or pain in my hands or feet.My cancer is not HER2 positive.My heart's electrical activity shows delays on an ECG.I am allergic to medications similar to vorinostat.My breast cancer is both ductal and lobular.My cancer is at a stage where it can't be removed by surgery and can be measured.Your bilirubin levels are within the normal range.Your white blood cell count is at least 1,500 per cubic millimeter.I am fully active or can carry out light work.Your hemoglobin level is at least 9 grams per deciliter.Your kidneys work well enough to filter out waste from your blood.Your liver enzymes (AST and ALT) should not be more than 2.5 times the upper limit of normal.I have no allergies to vorinostat or similar drugs.Your blood clotting tests should be within a certain range, and if you are taking warfarin, your dose should be stable.I have no severe allergies to drugs with polysorbate 80 or E. coli products.I am on HIV medication.Your creatinine levels are within a certain range.Your blood clotting test results are higher than the normal range.My cancer's hormone receptor status meets the trial's criteria.Your platelet count is at least 150,000 per cubic millimeter.Your alkaline phosphatase levels are not more than 2.5 times the normal upper limit.I am severely allergic to drugs with polysorbate 80 or E. coli products.My breast cancer was confirmed by a biopsy.I have skin cancer spread to the same side breast and will undergo chemotherapy before surgery.I do not have severe nerve damage in my hands or feet.My heart's electrical activity is normal according to my last ECG.I stopped taking breast cancer prevention medication like tamoxifen over a month ago.
- Group 1: Arm II
- Group 2: Arm I
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is enrollment for this clinical experiment still open?
"Evidently, this particular medical trial is no longer recruiting patients. Information on clinicaltrials.gov reveals it was first posted in May 1st 2008 and last modified January 27th 2022. Nonetheless, there are 3,827 other experiments that are currently open for recruitment."
Are there any historical investigations regarding carboplatin?
"Initial research into carboplatin was conducted by City of Hope Comprehensive Cancer Centre back in 1997; since then, 4471 trials have been completed. Currently, 1227 studies are underway across the United States with a large concentration at Birmingham, Alabama."
What is the aggregate number of participants that have signed up to take part in this experiment?
"Unfortunately, this clinical trial is no longer accepting candidates. Initially posted on 5/1/2008 and last updated on 1/27/2022, patients who are interested in participating in a study should consider the 2600 trials for breast cancer or 1227 trails using carboplatin as treatment options."
What pathologies can be managed by the administration of carboplatin?
"Carboplatin is a chemotherapy agent used to combat neoplasm metastasis. It also holds promise in treating acute pyelonephritis, lymphoma, non-Hodgkin's lymphoma and hypovolemic shock."
What potential risks exist in utilizing carboplatin as a treatment?
"The safety of carboplatin has been assessed as a 2 due to the presence of Phase 2 trial evidence, indicating that there is some data backing its security but none for efficacy."
How many settings is this research conducted in?
"Five medical centres are currently participating in this research study. These sites span from Birmingham to Annapolis and Indianapolis, with additional locations spread across the country. To ensure ease of access for enrolled patients, it is recommended that they choose a centre close to them whenever possible."
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