Diet and Exercise for Breast Cancer Side Effects
Trial Summary
What is the purpose of this trial?
This phase I/II trial studies how well dietary and exercise interventions work in reducing side effects in patients with stage I-IIIa breast cancer taking aromatase inhibitors. Anti-inflammatory Mediterranean dietary and bone strengthening exercise interventions may alleviate medication side effects such as joint and bone pain and protectively influence bone mineral density, improve heart functioning, and reduce risk of breast cancer recurrence in breast cancer patients taking aromatase inhibitors.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it requires that you continue taking aromatase inhibitors.
What data supports the effectiveness of the treatment for breast cancer side effects?
Is diet and exercise safe for managing breast cancer side effects?
How does the diet and exercise treatment for breast cancer side effects differ from other treatments?
This treatment is unique because it combines impact-aerobic and strength exercises with dietary habits to improve body composition and reduce fat tissue in breast cancer survivors treated with aromatase inhibitors. Unlike standard drug treatments, it focuses on lifestyle changes to manage side effects and improve overall health.17101112
Research Team
Catherine L. Carpenter, PhD
Principal Investigator
UCLA / Jonsson Comprehensive Cancer Center
Eligibility Criteria
This trial is for postmenopausal women with stage I-IIIa breast cancer who are currently taking aromatase inhibitors and experiencing joint pain. They should be in good health, at least 6 months past chemotherapy or radiation, not on bone loss medication, without severe bone density issues or fractures since starting AIs, and not already engaged in regular exercise.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized to receive either a controlled anti-inflammatory diet or undergo controlled exercise sessions with a dedicated trainer for 12 weeks
Follow-up
Participants are monitored for changes in inflammatory markers, joint and muscle pain, and bone mineral density
Treatment Details
Interventions
- Dietary Intervention
- Exercise Intervention
Find a Clinic Near You
Who Is Running the Clinical Trial?
Jonsson Comprehensive Cancer Center
Lead Sponsor