NAC for COVID-19
(NACinCOVID2 Trial)
Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: Cambridge Health Alliance
Prior Safety DataThis treatment has passed at least one previous human trial
Approved in 2 JurisdictionsThis treatment is already approved in other countries
Trial Summary
What is the purpose of this trial?
This trial is testing if taking an NAC supplement can make COVID-19 symptoms less severe and shorter in adults who have tested positive but are not hospitalized.
Eligibility Criteria
This trial is for individuals who have tested positive for COVID-19 within the past 7 days. It's not suitable for pregnant women or those already hospitalized due to COVID.Inclusion Criteria
Positive COVID test <= 7 days of enrollment
Exclusion Criteria
Pregnant
Already hospitalized due to COVID
Timeline
Screening
Participants are screened for eligibility to participate in the trial
1-2 weeks
Treatment
Participants receive NAC or placebo for 14 days
2 weeks
Daily online symptom-tracker for 3 weeks
Follow-up
Participants are monitored for symptom severity and duration, and need for hospitalization
24 weeks
Weekly online symptom-tracker for 3 weeks
Treatment Details
Interventions
- N-acetylcysteine
- Placebo
Trial Overview The study aims to see if taking N-acetylcysteine (NAC) orally can reduce the severity and length of COVID-19 symptoms compared to a placebo, which has no active ingredients.
Participant Groups
2Treatment groups
Experimental Treatment
Placebo Group
Group I: NACExperimental Treatment1 Intervention
Group receiving intervention/study drug NAC
Group II: PlaceboPlacebo Group1 Intervention
Group receiving placebo
N-acetylcysteine is already approved in United States, European Union for the following indications:
Approved in United States as N-acetylcysteine for:
- Acetaminophen overdose
- Chronic bronchitis
- Cystic fibrosis
- Mucolytic agent
Approved in European Union as N-acetylcysteine for:
- Paracetamol overdose
- Chronic bronchitis
- Cystic fibrosis
- Mucolytic agent
Find a Clinic Near You
Who Is Running the Clinical Trial?
Cambridge Health Alliance
Lead Sponsor
Trials
65
Recruited
22,400+
Alturix
Collaborator
Trials
1
Recruited
200+
The Thoracic Foundation
Collaborator
Trials
1
Recruited
200+
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