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Clinical Trials in Ohio
View paid research studies that are recruiting in Ohio. Filter by distance, duration, and inclusion criteria to find clinical trials that pay well for your time.
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CHK336
Cincinnati, OH
18 - 65
All Sexes
Phase 1
Recruiting
Cincinnati, OH
18 - 65
All Sexes
This study is designed to assess the safety, tolerability, pharmacokinetics and pharmacodynamic effects of an investigational drug (CHK-336) when administered to healthy volunteers.
LP352
Honolulu, HI
18+
All Sexes
Phase 1 & 2
Recruiting
Honolulu, HI
18+
All Sexes
The objective of this study is to assess the safety, tolerability, efficacy, and pharmacokinetics of adjunctive therapy of LP352 in adults with developmental and epileptic encephalopathies.
Dynamic high-cadence cycling
Kent, OH
18+
All Sexes
Recruiting
Kent, OH
18+
All Sexes
Parkinson's disease (PD) is a progressive neurological disorder that results in slowness of movement, muscle stiffness, tremor, and postural instability. These symptoms significantly affect PD patients' quality of life, independence, and functional performance. There is currently no cure f…
DexCom G6
Columbus, OH
18+
All Sexes
Recruiting
Columbus, OH
18+
All Sexes
In this 12-week prospective observational cohort study, hospitalized insulin-requiring patients with T2D will receive a Dexcom continuous glucose monitor (CGM) to wear post-hospital discharge. Patients will complete surveys assessing patient-reported outcomes prior to CGM use and following…
Tranexamic Acid
Cincinnati, OH
18+
All Sexes
Phase < 1
Recruiting
Cincinnati, OH
18+
All Sexes
This multi-center, prospective study will evaluate the use of topical tranexamic acid (TXA - Cyklokapron; Pfizer, New York, NY) on pre-operative and post-operative hemoglobin (Hb)/hematocrit (Hct) in patients undergoing operative repair of isolated posterior wall (PW) acetabular fractures.
HALO
Cincinnati, OH
Any Age
Female
Recruiting
Cincinnati, OH
Any Age
Female
This is the Phase 2 pilot/feasibility randomized controlled trial of HALO (Health And Lifestyle Behaviors In Offspring), a parent-led behavioral intervention targeting a high-risk pediatric population (i.e., residing offspring ages 6-12; body mass index > the 70th and < 120% of the 95th pe…
Combination - CITI-002 (high dose)
Gulfport, MS
18+
All Sexes
Phase 2
Recruiting
Grade II
Gulfport, MS
18+
All Sexes
A Randomized Phase 2 double blind study which aims to determine the safety and efficacy of CITI-002 cream in adult patients with Goligher's grade II or III hemorrhoids.
DTX301
Toronto, Canada
Any Age
All Sexes
Phase 3
Recruiting
Toronto, Canada
Any Age
All Sexes
The primary objective is to evaluate the efficacy of DTX301 on the improvement of ornithine transcarbamylase (OTC) function by maintaining safe plasma ammonia levels with removal of dietary protein restriction and alternative pathway medication.
DFD-29
Santa Monica, CA
18+
All Sexes
Phase 3
Recruiting
Grade III
Santa Monica, CA
18+
All Sexes
This is a 16-week, multicenter, randomized, parallel-group, double-blind, controlled study. After assessing eligibility during a screening period of up to 30 days, approximately 320 subjects at least 18 years old who are diagnosed with moderate to severe papulopustular rosacea will be rand…
Informational Intervention
Columbus, OH
18+
All Sexes
Recruiting
Locally Advanced
Columbus, OH
18+
All Sexes
This phase IIb trial studies the effect of a biobehavioral/cognitive (ABC) treatment on stress, depression, and anxiety in patients with stage IV lung cancer. Advanced lung cancer and stress or depression are associated with increased inflammation and decreased immunity. ABC is a combinati…
Downhill Eccentric Treadmill Training with Electrical Stimulation
Columbus, OH
18+
All Sexes
Recruiting
Columbus, OH
18+
All Sexes
The investigators are studying a new rehabilitation treatment for individuals trying to recover walking after spinal cord injury (SCI). The investigators will test conditions in the blood and spinal fluid to determine the best time to start this new training program. This will include chec…
Surgical Theater
Middleburg Heights, OH
18+
All Sexes
Recruiting
Middleburg Heights, OH
18+
All Sexes
To evaluate usefulness of Surgical Theater's Patient Engagement 360VR platform in helping align patient expectations and improve patient satisfaction and understanding in spinal surgery consults.
mRNA-1030
South Ogden, UT
18+
All Sexes
Phase 1 & 2
Recruiting
South Ogden, UT
18+
All Sexes
The primary objective of this study is to evaluate the safety, reactogenicity, and humoral immunogenicity of mRNA-1020, mRNA-1030, and mRNA-1010 vaccines against vaccine-matched influenza A and B strains.
Afluria® Quadrivalent
Las Vegas, NV
18+
All Sexes
Phase 3
Recruiting
Las Vegas, NV
18+
All Sexes
The main purposes of this study are to evaluate the safety and tolerability of mRNA-1345 coadministered with a seasonal influenza vaccine (Afluria® Quadrivalent); to evaluate the impact of coadministered influenza vaccine on the immune response to RSV; and to evaluate the impact of coadmin…
Nivolumab-relatlimab FDC
Fort Wayne, IN
18+
All Sexes
Phase 3
Recruiting
Metastatic
Fort Wayne, IN
18+
All Sexes
The purpose of this study is to evaluate relatlimab in combination with nivolumab, administered as a fixed-dose combination (nivolumab-relatlimab FDC, also referred to as BMS-986213) for the treatment of late-line microsatellite stable (MSS) metastatic colorectal cancer (mCRC) participants…
RSV preF-based Vaccine
Wichita, KS
18+
All Sexes
Phase 1 & 2
Recruiting
Grade II
Wichita, KS
18+
All Sexes
The purpose of the study is to evaluate safety and immunogenicity of various respiratory syncytial virus (RSV) pre-Fusion (preF)-based vaccine components followed by expanded safety evaluation and durability/revaccination evaluation of the selected RSV preF-based vaccine formulation in par…
GNX oral suspension, TID
Houston, TX
Any Age
All Sexes
Phase 3
Recruiting
Houston, TX
Any Age
All Sexes
This is a Phase 3, global, double-blind, randomized, placebo-controlled study of adjunctive GNX treatment in children and adults with TSC-related epilepsy. The study consists of a 4-week prospective baseline phase, defined as the first 28 days following screening, followed by a double-blin…
Whole Wheat Bread
Columbus, OH
18+
All Sexes
Recruiting
Columbus, OH
18+
All Sexes
This study will investigate the gut microbiota-mediated effects of whole wheat consumption on human health in adults with pre-diabetes. Participants will complete two phases of intervention in random order in which they will consume either whole wheat bread (4 servings) or white bread a da…
NXL Energy 3
Westerville, OH
18 - 65
All Sexes
Phase 1 & 2
Recruiting
Westerville, OH
18 - 65
All Sexes
Clinical Trial to Evaluate the Safety and Efficacy of Corneal Cross-linking in Subjects with Keratoconus.
STI-6129
Canton, OH
18+
All Sexes
Phase 1 & 2
Recruiting
1 Prior Treatment
Canton, OH
18+
All Sexes
This is a two-stage phase 1b/2a, open-label, multicenter, dose-escalation study of STI-6129 administered intravenously once in a 4-week cycle in subjects with relapsed or refractory multiple myeloma.
CG-Well
Cincinnati, OH
18+
All Sexes
Recruiting
Cincinnati, OH
18+
All Sexes
After injury, survivors of msTBI depend on informal family caregivers. Upwards of 77% of family caregivers experience poor outcomes, such as adverse life changes, poor health related quality of life, and increased depressive symptoms. Caregivers frequently report minimal support or trainin…
SPI-62
Canton, OH
18+
All Sexes
Phase 2
Recruiting
Canton, OH
18+
All Sexes
This is a randomized, placebo-controlled, crossover study of SPI-62 in subjects with ACTH-dependent Cushing's syndrome. Subjects will receive each of the following 2 treatments for 12 weeks: SPI-62 and matching placebo
Cognitive Behavior Therapy
Columbus, OH
18+
All Sexes
Recruiting
Columbus, OH
18+
All Sexes
This trial studies the effect of a form of cognitive-behavioral therapy, Take a Breath, on reducing the intensity and frequency of dyspnea (difficulty breathing) in patients with lung cancer. Take a Breath consists of individual therapy sessions that educate patients on dyspnea and provide…
Pediatric Constrained Induced Movement Therapy
Columbus, OH
< 18
All Sexes
Recruiting
Columbus, OH
< 18
All Sexes
The study will test a remotely delivered, intensive, therapist-led, pediatric CIMT intervention, to improve the quality and frequency of upper limb movement during functional activity. We will evaluate: remote assessment of patient motor outcomes; computer-based video interaction for paren…
Gabapentin
Cleveland, OH
18+
All Sexes
Phase 4
Recruiting
Cleveland, OH
18+
All Sexes
The objective of the proposed study is to conduct the first ever prospective, dose-exploration trial to test the feasibility of early administration of gabapentin as an intervention for neurorecovery. This research project falls under the Intervention Development stage of research as the p…
senofilcon A prototype
Granville, OH
18 - 65
All Sexes
Recruiting
Granville, OH
18 - 65
All Sexes
This study is a controlled, randomized, subject-masked, 2-arm parallel, 2-week dispensing, bilateral evaluation where the study lenses are worn for a minimum of 5 days per week and 6 hours per day.
Dynamic cycling
Cleveland, OH
18+
All Sexes
Recruiting
Cleveland, OH
18+
All Sexes
This research will develop novel and accessible way to deliver effective and customized rehab to those suffering from common and devastating neurodegenerative condition called Parkinson's disease. The investigators will examine the efficacy of novel rehab technique that can be monitored an…
DFD-29
Coral Gables, FL
18+
All Sexes
Phase 3
Recruiting
Grade III
Coral Gables, FL
18+
All Sexes
This is a 16-week, multicenter, randomized, parallel-group, double-blind, controlled study. After assessing eligibility during a screening period of up to 30 days, approximately 320 subjects at least 18 years old who are diagnosed with moderate to severe papulopustular rosacea will be rand…
motor learning based therapy
Cleveland, OH
18+
All Sexes
Recruiting
Cleveland, OH
18+
All Sexes
This study will evaluate the effects of combining motor learning-based therapy with use of the MyoPro , a wearable exoskeletal myoelectrically controlled orthotic device. MyoPro uses electromyographic (EMG) signals from the weak muscles to assist movement of the user's affected arm. The pr…
OPTIMA-BP Intervention
Cleveland, OH
18+
All Sexes
Recruiting
Cleveland, OH
18+
All Sexes
Hypertension (HTN) has a greater impact on African Americans (AA) than any other U.S. racial group. Uncontrolled blood pressure (BP) contributes to higher rates of disability, death, and health resource use among AA. HTN is the single most influential risk factor for cardiovascular disease…
PRECISION1® for Astigmatism Contact Lenses
Salem, VA
18 - 65
All Sexes
Recruiting
Salem, VA
18 - 65
All Sexes
This is a bilateral wear, dispensing, randomized, controlled, double-masked, 2-sequence ×2-period crossover study to evaluate ocular physiology following contact lens wear.
High-dose oxytocin
Columbus, OH
18 - 65
Female
Phase 4
Recruiting
Columbus, OH
18 - 65
Female
Pregnant patients with obesity are more likely to undergo induction of labor and have a higher risk of failed induction compared to patients with normal weight. The association between maternal obesity and labor dysfunction leading to cesarean delivery is poorly understood. Oxytocin is the…
Placement of stoma site enteral feeding tube accessory
Cleveland, OH
18+
All Sexes
Recruiting
Cleveland, OH
18+
All Sexes
The purpose of the study is to collect safety and efficacy data on the performance of the study stoma site accessory when used to prevent abdominal wall leakage for patients with a long term feeding tube. This accessory has been developed by the Cleveland Clinic and will be used for the f…
Prednisone or Prednisolone
Springdale, AR
18+
Male
Phase 3
Recruiting
Metastatic
Springdale, AR
18+
Male
The purpose of this study is to learn whether adding abemaciclib to abiraterone plus prednisone prolongs the time before prostate cancer gets worse. Participation may last approximately 60 months.
Cognitive Behavioral Therapy
Cleveland, OH
18+
All Sexes
Recruiting
Cleveland, OH
18+
All Sexes
A prospective controlled, randomized study to examine the effects of behavioral and wellness-based interventions on seizure frequency for adult patients with medication resistant epilepsy who are still experiencing 1 or more seizures per month.
Building Better Brains and Behavior program (B4 Preterm)
Cincinnati, OH
< 18
All Sexes
Recruiting
Cincinnati, OH
< 18
All Sexes
Open pilot of a brief online parenting-skills intervention for young children ages 3-8 who were born very preterm (< 32 weeks gestational age). Parent-child interactions, child behavior, parent functioning, and child white matter connectivity will be assessed pre- and post-intervention 10 …
tart cherry juice
Athens, OH
18 - 65
Male
Recruiting
Athens, OH
18 - 65
Male
The purpose of this study is to determine whether tart cherry supplementation effects thermotolerance and heat acclimation in human subjects exposed to exercise/heat stress. Specific Aim I. To determine if tart cherry in combination with repeated bouts of thermally stressful exercise will…
MedJet Device with intralesional triamcinolone
Cleveland, OH
< 18
All Sexes
Phase 4
Recruiting
Cleveland, OH
< 18
All Sexes
This is an interventional pilot study assessing the tolerability of needle-free delivery administration of ILTA with the Med-Jet as an alternative to conventional syringe and needle in patients with patchy pediatric alopecia areata. There will be a total of four (4) or five (5) visits nece…
Genome Informed Risk Assessment (GIRA) report
Chicago, IL
Any Age
All Sexes
Recruiting
High Risk
Chicago, IL
Any Age
All Sexes
The eMERGE Network embraces the opportunity to use new methods in genomic medicine, information science, and research participant engagement to identify people at very high risk for specific diseases and recommend individualized approaches to prevention and care. The investigators will con…
SL-172154
Duarte, CA
18+
All Sexes
Phase 1
Recruiting
Grade I
Duarte, CA
18+
All Sexes
SL03-Old Hundred(OHD)-104 is designed as a Phase 1a/1b open label, trial to evaluate the safety, pharmacokinetics (PK), pharmacodynamic (PD), and preliminary efficacy of SL-172154 monotherapy as well as in combination with azacitidine or in combination with Azacitidine and Venetoclax.
LY3209590
New Port Richey, FL
18+
All Sexes
Phase 3
Recruiting
New Port Richey, FL
18+
All Sexes
The reason for this study is to see if the study drug LY3209590 is safe and effective in participants with Type 2 diabetes that have already been treated with basal insulin. The study consists of a 3-week screening/lead-in period, a 78-week treatment period and a 5-week safety follow-up pe…
CRP
Columbus, OH
18+
All Sexes
Recruiting
Columbus, OH
18+
All Sexes
The current study is a clinical trial, meaning a research study in which human subjects are prospectively assigned to one or more interventions to evaluate the effects of those interventions on health-related behavioral outcomes. Specifically, male and female adults with current suicidal i…
TNX-102 SL
Kenosha, WI
18+
All Sexes
Phase 3
Recruiting
Kenosha, WI
18+
All Sexes
This is a Phase 3, randomized, parallel-group, double-blind, placebo-controlled, 14-week study designed to evaluate the efficacy and safety of TNX-102 SL 5.6 mg (2 x 2.8 mg tablets) taken daily at bedtime for the treatment of fibromyalgia.
Bilateral TMS
Cincinnati, OH
< 65
All Sexes
Recruiting
Cincinnati, OH
< 65
All Sexes
In this research study the investigators aim to learn more about the therapeutic effects of a newer form of non-invasive transcranial magnetic stimulation (TMS), called theta burst simulation (TBS), on refractory depression in Autism Spectrum Conditions.
Chiauranib
Canton, OH
18+
All Sexes
Phase 1 & 2
Recruiting
Metastatic
Canton, OH
18+
All Sexes
This is a Phase 1b/2, single-arm, open-label, dose-escalation study including 2 stages: Phase 1b: Dose-Escalation Stage (Single-Dose and Consecutive-Dose Periods) Phase 2: recommended Phase 2 dose (RP2D) of chiauranib will be given to all patients enrolled in this phase once daily for 28…
Movement to Music
Columbus, OH
18+
All Sexes
Recruiting
Columbus, OH
18+
All Sexes
The purpose of this study is to determine if a movement to music exercise program delivered via telehealth is feasible and safe for individuals with neurodegenerative disease and their caregivers (Aim 1). A secondary aim will be to determine if a movement to music exercise program delivere…
PRA023 IV
Washington, United States
18+
All Sexes
Phase 2
Recruiting
Washington, United States
18+
All Sexes
The purpose of this study is to assess the safety and efficacy of PRA023 in participants with SSc-ILD .
Abbott Infinity DBS systems with the NeuroSphere Virtual Clinic feature
Seattle, WA
18+
All Sexes
Recruiting
Seattle, WA
18+
All Sexes
The purpose of the ROAM-DBS study is to compare the time needed to achieve a 1 point improvement Patient's Global Impression of change (PGIC) relative to the subject's status at the end of the ADROIT initial programming visit in subjects who receive programming updates via in-clinic sessio…
LumiraDx SARS-CoV-2 & RSV test
Middleburg Heights, OH
Any Age
All Sexes
Recruiting
Middleburg Heights, OH
Any Age
All Sexes
A Multicenter Study Conducted to Evaluate the Performance of the LumiraDx SARS-CoV-2 & FLU A/B Test, and LumiraDx SARS-CoV-2 & RSV Test at Point of Care Testing Sites. Subjects presenting with symptoms suggestive of COVID-19 and/or Influenza and/or RSV will be consented and asked to donate…
Prednisone
Fairborn, OH
18+
All Sexes
Phase 2 & 3
Recruiting
Fairborn, OH
18+
All Sexes
ARGX-113-2009 is an operationally seamless 2-part, phase 2/3, prospective, global, multicenter, randomized, double-blinded, placebo-controlled study to investigate the efficacy, safety, tolerability, immunogenicity, participant-reported outcome measures (including those assessing participa…
Intervention #2: Control Group Receiving In-Person TYRO Services
McClure, OH
18+
All Sexes
Recruiting
McClure, OH
18+
All Sexes
This study uses an RCT design with repeated measures to test the impact of two different delivery formats for the TYRO Couples curriculum. Eligible study participants are males or females who are at least 18 years of age and within 9 months of release from incarceration. Incarcerated parti…
Pemigatinib
Santa Monica, CA
18+
All Sexes
Phase 2
Recruiting
Grade IV
Santa Monica, CA
18+
All Sexes
This is an open-label, monotherapy study of pemigatinib in participants with recurrent glioblatoma (GBM) or other primary CNS tumors with an activating FGFR1-3 mutation or fusion/rearrangement. This study consists of 3 cohorts, Cohorts A, B, and C, and will enroll approximately 82, 82, and…
Obicetrapib
Addison, IL
18+
All Sexes
Phase 2
Recruiting
Addison, IL
18+
All Sexes
This study will be a placebo-controlled, double-blind, randomized, phase 2 study to evaluate the efficacy, safety, and tolerability of obicetrapib 10 mg, both in combination with ezetimibe 10 mg and as monotherapy, as an adjunct to high-intensity statin therapy.
Survey Administration
Columbus, OH
18+
All Sexes
Recruiting
Columbus, OH
18+
All Sexes
This trial studies how well a video-based intervention works in helping participants encourage their families to get tested for BRCA gene mutations. Testing in families with BRCA gene mutations can allow for risk management and reduction with the overall goal of reducing cancer burden. Vid…
Atogepant
Raleigh, NC
18+
All Sexes
Phase 4
Recruiting
Raleigh, NC
18+
All Sexes
Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound. This study will assess the safety and efficacy of the combination use of ubrogepant for the acute treatment of migraine headache in part…
nirmatrelvir
Miami, FL
< 18
All Sexes
Phase 2 & 3
Recruiting
Miami, FL
< 18
All Sexes
The purpose of the study is to evaluate the safety, pharmacokinetics, and efficacy of nirmatrelvir/ritonavir for the treatment of nonhospitalized, symptomatic pediatric participants with coronavirus disease 2019 (COVID-19) who are at risk of progression to severe disease.
60 mg PRAX-114 or 40 mg PRAX-114
Media, PA
18+
All Sexes
Phase 2
Recruiting
Media, PA
18+
All Sexes
This trial is comprised of a 4-week randomized, double-blind, placebo-controlled treatment period followed by an optional 8-week open-label extension (OLE) period. This trial will evaluate the efficacy and safety of oral PRAX-114 flexibly dosed at 40 to 60 mg for 4 weeks compared to place…
CV2CoV (16 µg)
Little Rock, AR
18+
All Sexes
Phase 1
Recruiting
Little Rock, AR
18+
All Sexes
Prevention of COVID-19 caused by SARS-CoV-2.
Debriefing
Columbus, OH
< 18
All Sexes
Recruiting
Columbus, OH
< 18
All Sexes
The investigators' previous research has shown that children exposed to media characters with guns in movies and video games are more likely to use real guns themselves (e.g., touch them, hold them, pull the trigger). This research tests whether exposure to a gun safety video a week before…
Cebranopadol 600 µg
Columbus, OH
18 - 65
All Sexes
Phase 1
Recruiting
Columbus, OH
18 - 65
All Sexes
This study will be conducted to evaluate the abuse potential of single doses of cebranopadol as compared with oxycodone, tramadol and matching placebo in recreational drug users.
Benralizumab
Edmonton, Canada
Any Age
All Sexes
Phase 3
Recruiting
Edmonton, Canada
Any Age
All Sexes
This is a 3-part study. Part A and B have identical designs and are randomized, double-blinded, placebo-controlled studies, which will include patients with eosinophilic gastritis and/or duodenal-only disease. Part A will be enrolled first, followed by Part B. After completing Part A or Pa…
Dexamethasone
Toronto, Canada
18+
All Sexes
Phase 2
Recruiting
Stage II
Toronto, Canada
18+
All Sexes
The purpose of this study is to characterize cardiac safety of Daratumumab, Cyclophosphamide, Bortezomib, and Dexamethasone (D-VCd) treatment regimens (Arm A: immediate daratumumab + VCd treatment and Arm B: daratumumab + deferred VCd) in newly diagnosed systemic amyloid light chain (AL) a…
AGN-151586
Birmingham, MI
18+
All Sexes
Phase 3
Recruiting
Birmingham, MI
18+
All Sexes
Facial lines that develop from repeated facial expression, such as glabellar lines (GL), are typically treated by selectively weakening specific muscles with small quantities of botulinum toxin. AGN-151586 is an investigational product being developed for the treatment of GL. The purpose o…
CVL-231
Richardson, TX
18 - 65
All Sexes
Phase 1
Recruiting
Richardson, TX
18 - 65
All Sexes
The purpose of this trial is to characterize the effects of 2 oral doses (over 8 weeks total) of CVL-231 on ambulatory blood pressure and heart rate in patients with stable schizophrenia.
Diphenhydramine
Boardman, OH
18+
All Sexes
Phase 3
Recruiting
Boardman, OH
18+
All Sexes
The purpose of this study is to assess the efficacy of droperidol as a treatment of cannabinoid hyperemesis syndrome.
LOXO-260
Nashville, TN
Any Age
All Sexes
Phase 1
Recruiting
Locally Advanced
Nashville, TN
Any Age
All Sexes
The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-260. LOXO-260 may be used to treat cancer that has a change in a particular gene (known as the RET gene). Participation could last up to 24 months (2 years) and possibly longer if the …
A197 Ophthalmic Solution
Jacksonville, FL
18+
All Sexes
Phase 2
Recruiting
Jacksonville, FL
18+
All Sexes
The objectives of this trial are to assess the safety, tolerability and efficacy of A197 ophthalmic solution in comparison to a vehicle control in the treatment of subjects with Dry Eye Disease.
Thoracoscopy
Oakland, CA
< 65
All Sexes
Phase 3
Recruiting
Metastatic
Oakland, CA
< 65
All Sexes
This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done…
Ocrelizumab SC
Dayton, OH
18+
All Sexes
Phase 3
Recruiting
Dayton, OH
18+
All Sexes
This study will evaluate the pharmacokinetics, pharmacodynamics, safety, immunogenicity, and radiological and clinical effects of subcutaneous (SC) administration of ocrelizumab compared with the intravenous (IV) infusion of ocrelizumab in patients with either relapsing multiple sclerosis …
Default Duration order Panel
Columbus, OH
Any Age
All Sexes
Recruiting
Columbus, OH
Any Age
All Sexes
Study the efficacy of a package of behavioral economics strategies (versus an education-only control condition) in altering clinician behavior regarding antibiotic prescription duration for skin and soft tissue infection (SSTI).
KT-333
Cincinnati, OH
18+
All Sexes
Phase 1
Recruiting
1 Prior Treatment
Cincinnati, OH
18+
All Sexes
This Phase 1a/1b study will evaluate the safety, tolerability and the pharmacokinetics/pharmacodynamics (PK/PD) of KT-333 in Adult patients with Relapsed or Refractory Lymphomas, Large Granular Lymphocytic Leukemia, and Solid Tumors. The Phase 1a stage of the study will explore escalating …
Ohio RETAIN
Columbus, OH
18+
All Sexes
Recruiting
Columbus, OH
18+
All Sexes
The Retaining Employment and Talent after Injury/Illness Network (RETAIN) demonstration is a collaborative effort between the U.S. Department of Labor (DOL) and the Social Security Administration (SSA) to improve employment outcomes for individuals who experience injuries or illnesses that…
Rimegepant 75mg every other day dosing
Seattle, WA
18+
All Sexes
Phase 4
Recruiting
Seattle, WA
18+
All Sexes
The purpose of this study is to compare the efficacy and safety of daily and every other day dosing of rimegepant to placebo as a preventive treatment for episodic migraine.
Basimglurant
Chicago, IL
18+
All Sexes
Phase 2 & 3
Recruiting
Chicago, IL
18+
All Sexes
Trigeminal neuralgia (TN), also called "tic douloureux", is the most common form of craniofacial neuropathic pain and is considered the cause of one of the most painful afflictions known in medical practice. This study is designed to evaluate the efficacy and safety of 1.5mg - 3.5mg basim…
Omadacycline Injection [Nuzyra]
Orange, CA
< 18
All Sexes
Phase 1
Recruiting
Orange, CA
< 18
All Sexes
The purpose of this study is to evaluate the pharmacokinetics of a single dose of intravenous or oral omadacycline in children and adolescents with suspected or confirmed bacterial infections.
Atogepant
Santa Monica, CA
18+
All Sexes
Phase 3
Recruiting
Santa Monica, CA
18+
All Sexes
Migraine is characterized by attacks of throbbing, moderate or severe headache, often associated with nausea, vomiting, and/or sensitivity to light and/or sound. The study will assess safety and tolerability of atogepant when added to BOTOX, as well as prospectively evaluate the efficacy o…
BOTOX
Philadelphia, PA
18+
All Sexes
Phase 2
Recruiting
Philadelphia, PA
18+
All Sexes
Upper limb essential tremor (UL ET) is a movement disorder characterized by postural and/or kinetic tremor. It can cause difficulty with everyday tasks such as writing, pouring, and eating, and patients also experience associated social embarrassment. This study will assess how safe and ef…
ATI-450
Sugar Land, TX
18+
All Sexes
Phase 2
Recruiting
Sugar Land, TX
18+
All Sexes
This is a Phase 2a study to investigate the efficacy, safety, tolerability, pharmacokinetics, and pharmacodynamics of ATI-450 vs placebo in patients with moderate to severe Hidradenitis Suppurativa (HS).