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KPT-330 for Leukemia
Study Summary
This trial is for leukemia patients who have relapsed or become resistant to standard therapies. They will be given the drug KPT-330 to see if it prevents leukemia cells from growing and leads to their destruction.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2015 Phase 1 trial • 286 Patients • NCT01607892Trial Design
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- My brain or spinal cord disease is at a manageable stage.I do not plan to receive any non-study cancer treatments during the trial.I have not taken certain medications recently.I need more chemotherapy to help treat my condition.I have recovered from side effects of my previous cancer treatments.I agree not to breastfeed while participating in this study.I (or my guardian) can understand and sign the consent form.I cannot take or tolerate medications by mouth.My condition did not improve after two initial treatments.My doctor thinks more chemotherapy won't help me.I do not have any major health, mental, or social issues affecting my daily life.I have had cancer before, but not acute leukemia or under certain conditions.My leukemia has returned or is not responding to treatment.My cancer has returned after treatment more than once.I am between 1 and 21 years old.My organs are functioning well.I am a woman who can have children and have a confirmed negative pregnancy test.I am eligible for a stem cell transplant from a donor.My leukemia has spread to my brain.My body does not respond to blood or platelet transfusions.I am mostly active and can do most of my daily activities.
- Group 1: KPT-330
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Have any similar trials been run before this one?
"Since its debut in 2014, KPT-330 has become the subject of 48 ongoing studies around the world. Initially sponsored by Karyopharm Therapeutics Inc., this medication achieved Phase 1 approval after a 16 patient trial completed in 2014. Currently, clinical trials for KPT-330 are being conducted across 28 countries and 259 cities worldwide."
Is eligibility for this experiment restricted to participants above the age of 30?
"According to the established guidelines, patient enrolment will be accepted from as young as 12 months old up until 21 years of age."
What prerequisites must be met to access this medical trial?
"This trial is seeking to enrol sixteen individuals aged between one year and twenty-one years old that have been diagnosed with leukemia. Furthermore, the patient must not be responding to induction cycles, would not benefit from more cytotoxic chemotherapy as determined by their physician, have a CNS 1 or 2 disease status (excluding isolated relapse of CNS 3). Please refer to Section 11.1.3 for definitions of neurological diseases and how traumatic lumbar punctures should be interpreted in this instance."
To what extent is KPT-330 potentially perilous to individuals?
"Due to limited data on safety and efficacy, KPT-330 was assigned a rating of 1 when evaluated by our team at Power."
Are any participants being accepted for this research endeavor at present?
"Unfortunately, this clinical trial is not taking on applicants at the moment. It was initially published on March 1st 2014 and last updated November 28th 2022. If you are still searching for trials that may be of interest to you, there are currently 1561 studies actively recruiting patients with leukemia and 48 other medical trials looking for participants treated with KPT-330."
Has KPT-330 been investigated in any other investigations?
"In 2014, KPT-330 began to be studied at Children's Healthcare of Atlanta. Currently, there are 29 completed studies and 48 ongoing trials distributed around San Francisco in the Golden State of California."
How many different sites are overseeing this research endeavor?
"At present, 10 different sites are accepting patients for this clinical trial. These locations include San Francisco, New york and Milwaukee as well as 7 other metropolitan centres. To avoid excessive travel expenses associated with the study, it is recommend that you select a site closest to your residence."
How many subjects are participating in the research experiment?
"Unfortunately, this clinical trial is no longer enrolling patients. First posted on March 1st 2014 and last updated on November 28th 2022, it has now concluded its recruitment process. However, if you are still searching for studies related to cancer or KPT-330 specifically, there are currently 1561 trials recruiting participants with leukemia and 48 actively looking for volunteers taking part in the KPT-330 study respectively."
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