allogeneic hematopoietic stem cell transplantation for Acute Myeloid Leukemia
Study Summary
This trial is studying the safety and efficacy of total marrow and lymphoid irradiation given before a donor stem cell transplant in treating patients with high-risk acute lymphocytic leukemia or acute myeloid leukemia who have failed previous therapy.
- Acute Myeloid Leukemia (AML)
- Childhood Acute Myeloid Leukemia (AML)
- Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Adult Acute Myeloid Leukemia With Del(5q)
- Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
- Acute Promyelocytic Leukemia (APL)
- Acute Myeloid Leukemia (AML) With t(16;16)(p13;q22)
- Acute Lymphoblastic Leukemia (ALL)
- Childhood Acute Lymphoblastic Leukemia (ALL)
Treatment Effectiveness
Effectiveness Progress
Study Objectives
2 Primary · 9 Secondary · Reporting Duration: Up to 5 years
Trial Safety
Safety Progress
Side Effects for
Trial Design
1 Treatment Group
Treatment (TMLI, chemotherapy)
1 of 1
Experimental Treatment
87 Total Participants · 1 Treatment Group
Primary Treatment: allogeneic hematopoietic stem cell transplantation · No Placebo Group · Phase 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 16 - 60 · All Participants · 15 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
Am I permitted to participate in this research?
"Potential participants in this clinical trial must have a diagnosis of leukemia and be between the ages 16-60. Up to 87 individuals will be accepted for the study." - Anonymous Online Contributor
What is the current capacity for participants in this medical experiment?
"Affirmative. As per the information available on clinicaltrials.gov, this research endeavour is currently enrolling participants and was first launched in May 12th 2014 with an update made on 19th of May 2022. The team needs a total of 87 patients from 1 site to participate in the trial." - Anonymous Online Contributor
Are there still opportunities to partake in this clinical assessment?
"As per the details on clinicaltrials.gov, this investigation is actively seeking participants. Initial information about the study was posted online at May 12th 2014 and the most recent update came out on May 19th 2022." - Anonymous Online Contributor
What medical conditions are typically treated with allogeneic hematopoietic stem cell transplantation?
"Allogeneic hematopoietic stem cell transplantation can offer relief from leukemia, prostate cancer, and lung cancers." - Anonymous Online Contributor
Are subjects of 45 years and above eligible to partake in this investigation?
"As outlined by the study's criteria, individuals that are of age 16 and above yet below 60 qualify for enrolment." - Anonymous Online Contributor
Have researchers conducted prior experiments on the use of allogeneic hematopoietic stem cell transplantation?
"Presently, there are 993 extant investigations into allogeneic hematopoietic stem cell transplantation with 204 of those being in Phase 3. Although most research is taking place in Philadelphia, Pennsylvania, trials for this treatment abound at 36293 different sites worldwide." - Anonymous Online Contributor
What are the attendant dangers of undergoing allogeneic hematopoietic stem cell transplantation?
"The safety of allogeneic hematopoietic stem cell [transplant](https://www.withpower.com/clinical-trials/transplant)ation is rated as a 2 on the 1-3 scale. This indicates that there have been some studies which show evidence for its security, but no trials to prove efficacy as it is still in Phase 2." - Anonymous Online Contributor