Cognitive Training for Mild Cognitive Impairment
(COGIT-2 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine how varying amounts of crossword puzzle activities might help people with mild cognitive impairment (MCI) enhance their memory and thinking skills through Cognitive Training (also known as Computerized Cognitive Training or Brain Training). Researchers will compare the effects of completing four crossword puzzles per week, one crossword puzzle per week, and participating in health education. This trial suits individuals who notice memory or thinking challenges and have access to a computer or tablet with internet. As a Phase 2 trial, the research measures the treatment's effectiveness in an initial, smaller group, allowing participants to contribute to early-stage findings.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are using certain medications that negatively impact cognition, like high doses of benzodiazepines, narcotics, or anticholinergics. If you are taking medications with anticholinergic or antihistaminergic properties, they will be reviewed to determine eligibility.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research shows that doing crosswords is generally safe and easy to handle. Past studies have demonstrated that crossword puzzles improve thinking skills in older adults with mild memory problems, without causing any adverse side effects. This holds true for both frequent and occasional crossword puzzle practice. No evidence suggests that doing crosswords leads to negative effects. Participants solve puzzles online, which has been shown to sharpen memory. This type of training is non-invasive, meaning it doesn't involve surgery or entering the body, and is considered low-risk.12345
Why are researchers excited about this trial's treatments?
Researchers are excited about these cognitive training techniques because they offer a novel, non-pharmacological approach to managing mild cognitive impairment. Unlike standard treatments that often involve medications to manage symptoms, these methods focus on actively engaging the brain. The use of web-based crossword training, especially in varying doses, aims to enhance cognitive function through mental exercises, potentially strengthening brain health without the side effects associated with drugs. This personalized, interactive approach could lead to a more sustainable and enjoyable way to maintain cognitive abilities over time.
What evidence suggests that this trial's treatments could be effective for mild cognitive impairment?
An earlier study found that doing crossword puzzles was more effective than using computer programs for improving memory and thinking skills in people with mild cognitive impairment (MCI). This was linked to less brain shrinkage, particularly in areas crucial for memory. In this trial, participants will be assigned to different groups to evaluate the effects of crossword training. The study examines both low-dose (one puzzle per week) and high-dose (four puzzles per week) crossword training to determine if doing more puzzles each week might have a stronger effect. Early results suggest that crossword puzzles could be a simple and effective way to enhance brain health in individuals at risk for dementia.13678
Are You a Good Fit for This Trial?
This trial is for people aged 55-89 with mild cognitive impairment (MCI), who have an informant to report on their functioning, access to a computer or tablet with internet, and can read English at a 6th-grade level. Women must be post-menopausal. Participants need documented memory impairment but still score above a certain threshold on a cognitive assessment.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive cognitive training with crosswords or health education for 12 weeks
Booster Sessions
Participants receive booster sessions of cognitive training or health education at specified intervals
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Cognitive Training
Find a Clinic Near You
Who Is Running the Clinical Trial?
Columbia University
Lead Sponsor
National Institute on Aging (NIA)
Collaborator