Cognitive Reappraisal by Distancing for Borderline Personality Disorder

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Icahn School of Medicine at Mount Sinai, New York, NYBorderline Personality DisorderCognitive Reappraisal by Distancing - Behavioral
Eligibility
18 - 55
All Sexes
What conditions do you have?
Select

Study Summary

This trial will test a new clinical intervention for patients with Borderline Personality Disorder. The intervention is training in reappraisal-by-distancing, which is hypothesized to improve neural and behavioral targets. If successful, this intervention has the potential to improve clinical outcomes for patients with BPD.

Eligible Conditions
  • Borderline Personality Disorder

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

2 Primary · 6 Secondary · Reporting Duration: Baseline and at 2-,4-, and 6-weeks and 1 and 4 months after treatment ends.

Month 4
Change in Affective Lability Scale total (ALS)
Change in Beck Depression Scale score (BDI)
Change in Difficulty in Emotion Regulation Scale Scores (DERS)
Change in Perceived Stress Scale (PSS)
Change in State-Trait Anxiety Scale Score (STAXI)
Change in ZAN-BPD sector scores
Week 6
Change in PINES Network activity
Change in Zanarini Rating Scale for Borderline Personality (ZAN-BPD)

Trial Safety

Trial Design

2 Treatment Groups

Control Downregulate Condition (CD)
1 of 2
Cognitive Reappraisal-by-Distancing (CRD)
1 of 2

Active Control

Experimental Treatment

228 Total Participants · 2 Treatment Groups

Primary Treatment: Cognitive Reappraisal by Distancing · No Placebo Group · N/A

Cognitive Reappraisal-by-Distancing (CRD)
Behavioral
Experimental Group · 1 Intervention: Cognitive Reappraisal by Distancing · Intervention Types: Behavioral
Control Downregulate Condition (CD)
Behavioral
ActiveComparator Group · 1 Intervention: Control Downregulate Condition · Intervention Types: Behavioral

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: baseline and at 2-,4-, and 6-weeks and 1 and 4 months after treatment ends.

Who is running the clinical trial?

Icahn School of Medicine at Mount SinaiLead Sponsor
790 Previous Clinical Trials
508,731 Total Patients Enrolled
3 Trials studying Borderline Personality Disorder
209 Patients Enrolled for Borderline Personality Disorder
William Marsh Rice UniversityOTHER
40 Previous Clinical Trials
26,573 Total Patients Enrolled
National Institute of Mental Health (NIMH)NIH
2,584 Previous Clinical Trials
1,984,510 Total Patients Enrolled
10 Trials studying Borderline Personality Disorder
1,583 Patients Enrolled for Borderline Personality Disorder
Harold Koenigsberg, MDPrincipal InvestigatorIcahn School of Medicine at Mount Sinai
1 Previous Clinical Trials
40 Total Patients Enrolled
1 Trials studying Borderline Personality Disorder
40 Patients Enrolled for Borderline Personality Disorder

Eligibility Criteria

Age 18 - 55 · All Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:

Who else is applying?

What state do they live in?
Iowa33.3%
New York33.3%
Florida33.3%
How old are they?
18 - 65100.0%
What site did they apply to?
Icahn School of Medicine at Mount Sinai100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%
Why did patients apply to this trial?
  • "Really just looking for any additional treatment options. I already do weekly therapy and try to practice DBT skills on my own but many days are still discouraging"

How responsive is this trial?

Typically responds via
Phone Call50.0%
Email50.0%
Most responsive sites:
  1. Icahn School of Medicine at Mount Sinai: < 48 hours
Average response time
  • < 2 Days

Frequently Asked Questions

Is the research project currently seeking participants?

"Indeed, the information accessible on clinicaltrials.gov claims that this medical trial is presently recruiting volunteers. The study was initially posted on November 30th 2021 and has been recently amended as of July 7th 2022. A total of 228 individuals are required at a single clinical centre for enrollment in the trial to be completed." - Anonymous Online Contributor

Unverified Answer

Is participation in this trial limited to individuals of a certain age bracket?

"The investigators for this trial have specified that only those aged 18 to 55 can be enrolled. For younger and elderly participants, there are 6 separate studies available for their consideration." - Anonymous Online Contributor

Unverified Answer

Who is the optimal participant for this clinical research?

"This trial is enrolling 228 suitable participants aged 18 - 55 diagnosed with Borderline Personality Disorder. To qualify, applicants must be medically sound and mentally capable of giving informed consent in written form." - Anonymous Online Contributor

Unverified Answer

What are the primary goals that this trial is aiming to accomplish?

"This medical trial's primary outcome is the Change in Zanarini Rating Scale for Borderline Personality (ZAN-BPD). Secondary outcomes are the Difficulty in Emotion Regulation Scale Scores (DERS) from 6 to 216, Beck Depression Inventory Score 0-63, and State-Trait Anxiety Inventory score 20 - 80. All of these metrics will be assessed at Baseline and up to 6 weeks into treatment." - Anonymous Online Contributor

Unverified Answer

To what extent is the public participating in this experiment?

"Correct. Documentation on clinicaltrials.gov attests to this experiment being currently open for recruitment, with the initial posting date of November 30th 2021 and last update dated July 7th 2022. The study is aiming to enroll 228 participants from a single location." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.