Cognitive Reappraisal Training for Borderline Personality Disorder
(BPD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to test a new way of helping people with Borderline Personality Disorder (BPD) manage their emotions by teaching them to think differently about emotional events. This method, called cognitive reappraisal training, could improve their mental health and behavior.
Will I have to stop taking my current medications?
The trial does not require you to stop your current medications, as long as there has been no change in your treatment in the last 2 months.
How is the treatment Cognitive Reappraisal by Distancing different from other treatments for Borderline Personality Disorder?
Cognitive Reappraisal by Distancing is unique because it focuses on teaching individuals to change their perspective on negative emotions, which can help improve emotional stability. This approach is different from other treatments that may not specifically target the way patients perceive and manage their emotions.12345
What data supports the effectiveness of the treatment Cognitive Reappraisal by Distancing for Borderline Personality Disorder?
Research shows that cognitive reappraisal, a strategy to change how we think about situations to alter our emotional response, is used less effectively by individuals with Borderline Personality Disorder (BPD) compared to healthy individuals. However, metacognitive therapies, which include elements of cognitive reappraisal, have shown promise in reducing BPD symptoms and improving emotional regulation.13456
Who Is on the Research Team?
Harold Koenigsberg, MD
Principal Investigator
Icahn School of Medicine at Mount Sinai
Are You a Good Fit for This Trial?
This trial is for medically healthy adults with Borderline Personality Disorder who can provide informed consent. It's not open to individuals over 55 or those with Schizotypal Personality Disorder or Avoidant Personality Disorder, due to their distinct neural activity patterns.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive cognitive reappraisal training twice a week for 2, 4, or 6 weeks to identify the optimal dose
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments at 1 and 4 months
Open-label extension (optional)
Participants may opt into continuation of cognitive reappraisal training long-term
What Are the Treatments Tested in This Trial?
Interventions
- Cognitive Reappraisal by Distancing
- Control Downregulate Condition
Find a Clinic Near You
Who Is Running the Clinical Trial?
Icahn School of Medicine at Mount Sinai
Lead Sponsor
National Institute of Mental Health (NIMH)
Collaborator
William Marsh Rice University
Collaborator