Cognitive Reappraisal by Distancing for Borderline Personality Disorder
Study Summary
This trial will test a new clinical intervention for patients with Borderline Personality Disorder. The intervention is training in reappraisal-by-distancing, which is hypothesized to improve neural and behavioral targets. If successful, this intervention has the potential to improve clinical outcomes for patients with BPD.
- Borderline Personality Disorder
Treatment Effectiveness
Effectiveness Progress
Study Objectives
2 Primary · 6 Secondary · Reporting Duration: Baseline and at 2-,4-, and 6-weeks and 1 and 4 months after treatment ends.
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
Control Downregulate Condition (CD)
1 of 2
Cognitive Reappraisal-by-Distancing (CRD)
1 of 2
Active Control
Experimental Treatment
228 Total Participants · 2 Treatment Groups
Primary Treatment: Cognitive Reappraisal by Distancing · No Placebo Group · N/A
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18 - 55 · All Participants · 1 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Who else is applying?
What state do they live in?
| Iowa | 33.3% |
| New York | 33.3% |
| Florida | 33.3% |
How old are they?
| 18 - 65 | 100.0% |
What site did they apply to?
| Icahn School of Medicine at Mount Sinai | 100.0% |
What portion of applicants met pre-screening criteria?
| Met criteria | 100.0% |
Why did patients apply to this trial?
- "Really just looking for any additional treatment options. I already do weekly therapy and try to practice DBT skills on my own but many days are still discouraging"
How responsive is this trial?
Typically responds via
| Phone Call | 50.0% |
| 50.0% | |
Most responsive sites:
- Icahn School of Medicine at Mount Sinai: < 48 hours
Average response time
- < 2 Days
Frequently Asked Questions
Is the research project currently seeking participants?
"Indeed, the information accessible on clinicaltrials.gov claims that this medical trial is presently recruiting volunteers. The study was initially posted on November 30th 2021 and has been recently amended as of July 7th 2022. A total of 228 individuals are required at a single clinical centre for enrollment in the trial to be completed." - Anonymous Online Contributor
Is participation in this trial limited to individuals of a certain age bracket?
"The investigators for this trial have specified that only those aged 18 to 55 can be enrolled. For younger and elderly participants, there are 6 separate studies available for their consideration." - Anonymous Online Contributor
Who is the optimal participant for this clinical research?
"This trial is enrolling 228 suitable participants aged 18 - 55 diagnosed with Borderline Personality Disorder. To qualify, applicants must be medically sound and mentally capable of giving informed consent in written form." - Anonymous Online Contributor
What are the primary goals that this trial is aiming to accomplish?
"This medical trial's primary outcome is the Change in Zanarini Rating Scale for Borderline Personality (ZAN-BPD). Secondary outcomes are the Difficulty in Emotion Regulation Scale Scores (DERS) from 6 to 216, Beck Depression Inventory Score 0-63, and State-Trait Anxiety Inventory score 20 - 80. All of these metrics will be assessed at Baseline and up to 6 weeks into treatment." - Anonymous Online Contributor
To what extent is the public participating in this experiment?
"Correct. Documentation on clinicaltrials.gov attests to this experiment being currently open for recruitment, with the initial posting date of November 30th 2021 and last update dated July 7th 2022. The study is aiming to enroll 228 participants from a single location." - Anonymous Online Contributor