This trial is evaluating whether Computer assisted ambulatory electroencephalogram will improve 1 primary outcome in patients with Early-Onset Alzheimer's Disease (AD). Measurement will happen over the course of 48 hours.
This trial requires 20 total participants across 1 different treatment group
This trial involves a single treatment. Computer Assisted Ambulatory Electroencephalogram is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"Al-Aβ/Tau proteins in brain can be detected by immunohistochemistry using anti-A β antibodies, and brain Aβ plaques can be identified using IHC using anti-Aβ antibody for amyloid. The abnormal plaques are similar in appearance to TDP-43 protein deposits (TDP-43 labelling), and thus both may be used as pathological markers of dementia with TDP-43 pathology (as described in Dementia (not specified) with TDP-43 inclusions (DSM-IV)). This is the first study to demonstrate TDP-43 in the cerebral arteries of a human patient with WMS." - Anonymous Online Contributor
"Alzheimer's disease is a progressive neurodegenerative brain disease in which beta-amyloid plaques, tangles and neurofibrillary tangles are prominent features in the brain of individuals with Alzheimer's whose disease is so advanced that they are unable to care for themselves." - Anonymous Online Contributor
"About 7,000 people in the United States were diagnosed with Alzheimer's disease in 1976, and this number has increased to more than 38,000 by 2006. These rates will increase with age. Alzheimer's disease is the leading cause of death among seniors in the United States." - Anonymous Online Contributor
"Almost half of people with probable AD are treated with cholinesterase inhibitors, antipsychotics are common as well. Physical therapy is also used in many cases of AD. The use of psychoactive drugs is common for both dementia and depressive disorders. There is evidence of improved quality of life for people diagnosed with dementia, with treatment to reduce cognitive and functional impairments. There are evidence based initiatives to help people with dementia live in the community rather than in nursing homes and units." - Anonymous Online Contributor
"At this time, no good evidence exists to support the use of any medical therapy for the induction and/or stabilization of Alzheimer's disease. However, in those patients who remain symptomatic as their disease advances, no curative therapies are available." - Anonymous Online Contributor
"We cannot rule out that a number of possible causes for AD lie outside the domain of knowledge currently available. Many of the factors associated with AD have multiple possible causes; it is not possible to exclude the possibility that any one cause plays a dominant role." - Anonymous Online Contributor
"A large proportion (47.3%) of patients with AD and VSD had abnormal EEG waveform patterns when compared to controls; in spite of this a large proportion (72%) of VSD patients were clinically normal. We suggest that AD can be distinguished from VSD on EEG alone (without prior imaging) using a two-stage diagnostic algorithm." - Anonymous Online Contributor
"In this small study, computer-assisted ambulatory EEG was found to be a useful tool for monitoring disease progression in individuals with dementia who have seizures. Future studies should clarify whether computer-assisted ambulatory EEG could improve quality of life in dementia patients." - Anonymous Online Contributor
"In a recent study, findings identifies a potential link between amyloid-concentrated plaques in the brains of those with pre-alzheimer disease and the severity of memory deficits in adults that were amyloid positive." - Anonymous Online Contributor
"In terms of treatment of non-convulsive seizures, the newest technologies (i.e., the multichannel ECoG technology), which are now clinically available, could be useful also during ambulatory electroencephalogram recordings when these are necessary." - Anonymous Online Contributor
"In people with dementia, early detection of sub-syndromes and [early diagnosis, initiation & management of medication]] may lead to better outcomes in the disease course and may reduce the burden of suffering by family and carers." - Anonymous Online Contributor
"There is strong evidence that individuals with AD are more likely to have genetic relatives with AD as well as having their relatives with AD, which raises the possibility that AD is caused by familial factors, including genetic factors and environmental factors." - Anonymous Online Contributor