Computer assisted ambulatory electroencephalogram for Early-Onset Alzheimer's Disease (AD)

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Mayo Clinic in Florida, Jacksonville, FL
Early-Onset Alzheimer's Disease (AD)+1 More
Computer assisted ambulatory electroencephalogram - DiagnosticTest
Eligibility
18 - 65
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a computer assisted EEG can help determine the frequency of seizures in individuals with early onset Alzheimer's disease.

See full description

Eligible Conditions

  • Early-Onset Alzheimer's Disease (AD)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Computer assisted ambulatory electroencephalogram will improve 1 primary outcome in patients with Early-Onset Alzheimer's Disease (AD). Measurement will happen over the course of 48 hours.

48 hours
Electrographic seizures: Number of subjects with electrographic seizures

Trial Safety

Safety Progress

1 of 3

Trial Design

1 Treatment Group

Early-onset Alzheimer's disease (EOAD) subjects
1 of 1
Experimental Treatment

This trial requires 20 total participants across 1 different treatment group

This trial involves a single treatment. Computer Assisted Ambulatory Electroencephalogram is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Early-onset Alzheimer's disease (EOAD) subjects
DiagnosticTest
Subjects with mild cognitive impairment due to EOAD will undergo a 48 hour computer assisted ambulatory electroencephalogram

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 48 hours
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 48 hours for reporting.

Who is running the study

Principal Investigator
N. R. G. M.
Neill R. Graff-Radford M.D., Principal Investigator
Mayo Clinic

Closest Location

Mayo Clinic in Florida - Jacksonville, FL

Eligibility Criteria

This trial is for patients born any sex between 18 and 65 years old. There are 8 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
40 to 64 years of age
Meets NIA-AA criteria for mild cognitive impairment (MCI) due to AD or probable AD dementia.
Have a global CDR score of ≤ 1.0
Have capacity to provide informed consent (ICF) or has a legal authorized representative or guardian who provides IC.
Amyloid positive status (PET scan with evidence of elevated amyloid)
Must have a study partner (informant) who spends a minimum average of 10 hours per week with the participant (e.g., family member, significant other, friend, and caregiver) who is generally aware of the participants' daily activities and can provide information about the participant's cognitive and functional performance. If the participant does not have a study partner who spends 10 face-to-face hours per week, other arrangements for identifying a viable study partner will be granted on a case-by-case basis by the Site PI.
Not pregnant or lactating. Women must be two years post-menopausal, be surgically sterile, or have a negative pregnancy test prior to each PET scan
Fluent in English.

Patient Q&A Section

What are the signs of alzheimer disease?

"Al-Aβ/Tau proteins in brain can be detected by immunohistochemistry using anti-A β antibodies, and brain Aβ plaques can be identified using IHC using anti-Aβ antibody for amyloid. The abnormal plaques are similar in appearance to TDP-43 protein deposits (TDP-43 labelling), and thus both may be used as pathological markers of dementia with TDP-43 pathology (as described in Dementia (not specified) with TDP-43 inclusions (DSM-IV)). This is the first study to demonstrate TDP-43 in the cerebral arteries of a human patient with WMS." - Anonymous Online Contributor

Unverified Answer

What is alzheimer disease?

"Alzheimer's disease is a progressive neurodegenerative brain disease in which beta-amyloid plaques, tangles and neurofibrillary tangles are prominent features in the brain of individuals with Alzheimer's whose disease is so advanced that they are unable to care for themselves." - Anonymous Online Contributor

Unverified Answer

How many people get alzheimer disease a year in the United States?

"About 7,000 people in the United States were diagnosed with Alzheimer's disease in 1976, and this number has increased to more than 38,000 by 2006. These rates will increase with age. Alzheimer's disease is the leading cause of death among seniors in the United States." - Anonymous Online Contributor

Unverified Answer

What are common treatments for alzheimer disease?

"Almost half of people with probable AD are treated with cholinesterase inhibitors, antipsychotics are common as well. Physical therapy is also used in many cases of AD. The use of psychoactive drugs is common for both dementia and depressive disorders. There is evidence of improved quality of life for people diagnosed with dementia, with treatment to reduce cognitive and functional impairments. There are evidence based initiatives to help people with dementia live in the community rather than in nursing homes and units." - Anonymous Online Contributor

Unverified Answer

Can alzheimer disease be cured?

"At this time, no good evidence exists to support the use of any medical therapy for the induction and/or stabilization of Alzheimer's disease. However, in those patients who remain symptomatic as their disease advances, no curative therapies are available." - Anonymous Online Contributor

Unverified Answer

What causes alzheimer disease?

"We cannot rule out that a number of possible causes for AD lie outside the domain of knowledge currently available. Many of the factors associated with AD have multiple possible causes; it is not possible to exclude the possibility that any one cause plays a dominant role." - Anonymous Online Contributor

Unverified Answer

What does computer assisted ambulatory electroencephalogram usually treat?

"A large proportion (47.3%) of patients with AD and VSD had abnormal EEG waveform patterns when compared to controls; in spite of this a large proportion (72%) of VSD patients were clinically normal. We suggest that AD can be distinguished from VSD on EEG alone (without prior imaging) using a two-stage diagnostic algorithm." - Anonymous Online Contributor

Unverified Answer

Does computer assisted ambulatory electroencephalogram improve quality of life for those with alzheimer disease?

"In this small study, computer-assisted ambulatory EEG was found to be a useful tool for monitoring disease progression in individuals with dementia who have seizures. Future studies should clarify whether computer-assisted ambulatory EEG could improve quality of life in dementia patients." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of alzheimer disease?

"In a recent study, findings identifies a potential link between amyloid-concentrated plaques in the brains of those with pre-alzheimer disease and the severity of memory deficits in adults that were amyloid positive." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in computer assisted ambulatory electroencephalogram for therapeutic use?

"In terms of treatment of non-convulsive seizures, the newest technologies (i.e., the multichannel ECoG technology), which are now clinically available, could be useful also during ambulatory electroencephalogram recordings when these are necessary." - Anonymous Online Contributor

Unverified Answer

How serious can alzheimer disease be?

"In people with dementia, early detection of sub-syndromes and [early diagnosis, initiation & management of medication]] may lead to better outcomes in the disease course and may reduce the burden of suffering by family and carers." - Anonymous Online Contributor

Unverified Answer

Does alzheimer disease run in families?

"There is strong evidence that individuals with AD are more likely to have genetic relatives with AD as well as having their relatives with AD, which raises the possibility that AD is caused by familial factors, including genetic factors and environmental factors." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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