Noninvasive Brain Stimulation for Alzheimer's Disease
Trial Summary
Will I have to stop taking my current medications?
The trial allows participants to continue taking certain medications, including antidepressants, Alzheimer's medications, and various heart and blood pressure medications. However, if you are on medications not listed, it's best to check with the trial coordinators.
What data supports the effectiveness of the treatment for Alzheimer's disease?
Research suggests that transcranial direct current stimulation (tDCS), a noninvasive method of brain stimulation, may help improve cognitive function and slow cognitive decline in people with Alzheimer's disease. Studies have shown improvements in memory and cognitive stability, indicating potential benefits of this treatment.12345
Is noninvasive brain stimulation safe for humans?
How does noninvasive brain stimulation differ from other treatments for Alzheimer's disease?
Noninvasive brain stimulation, specifically transcranial direct current stimulation (tDCS), is unique because it uses a mild electrical current to stimulate the brain without the need for medication. This method is non-pharmacological, meaning it doesn't involve drugs, and it aims to improve cognitive function and delay cognitive decline in Alzheimer's patients.1291011
What is the purpose of this trial?
The investigators will evaluate the theory that Alzheimer's disease-related memory impairment derives from the inefficient orchestration of rhythmic activity at the level of large-scale cortical networks. The results as expected to elucidate AD-related pathophysiology and set groundwork for the development of drug-free interventions for improving memory in AD and related dementias.
Eligibility Criteria
This trial is for people aged 50-100 with Alzheimer's or mild cognitive impairment due to Alzheimer's, having certain memory performance scores. Healthy individuals can join if they meet specific cognitive norms. Participants must not have severe mental health issues, significant past brain conditions, or be on excluded medications.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive low-intensity, high-definition, transcranial electrical current stimulation while performing computer-based tasks
Follow-up
Participants are monitored for memory performance and cognitive function after treatment
Treatment Details
Interventions
- High definition transcranial electrical current stimulation
Find a Clinic Near You
Who Is Running the Clinical Trial?
Boston University Charles River Campus
Lead Sponsor