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Narrowband UVB phototherapy for Eczema(BRONTE Trial)

Women's College Hospital, Toronto, Canada
Targeting 3 different conditionsNarrowband UVB phototherapy +1 moreN/ARecruitingLed by Aaron M DruckerResearch Sponsored by Women's College Hospital

BRONTE Trial Summary

This trial is testing two types of light therapy to see which one works better to treat eczema. The trial will also collect data on participants' eczema severity and use of treatments, as well as blood and skin samples from participants who give permission, to study the mechanisms underlying the disease.

Eligible Conditions
  • Atopic Dermatitis
  • Skin Diseases

BRONTE Trial Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below
Your symptoms are severe according to the doctor's evaluation.
You have a skin condition called atopic dermatitis as defined by certain medical criteria.
Your condition is not improving even after trying different creams or ointments.

BRONTE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 12
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 12 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mean change in the Eczema Area and Severity Index (EASI) from baseline
Secondary outcome measures
Mean change in the Dermatology Life Quality Index (DLQI) from baseline
Mean change in the Patient Oriented Eczema Measure (POEM) from baseline
Mean change in the Peak Pruritus Numeric Rating Scale (PP-NRS) from baseline
+2 more
Other outcome measures
Change in the patient global assessment scale from baseline
Mean change in EuroQol-5D-5L (EQ5D-5L) from baseline
Mean change in body surface area (BSA) from baseline
+1 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

BRONTE Trial Design

2Treatment groups
Active Control
Group I: Narrowband UVBActive Control1 Intervention
Narrowband UVB phototherapy (full body) administered three times weekly according to individual clinical protocols.
Group II: Broadband UVBActive Control1 Intervention
Broadband UVB phototherapy (full body) administered three times weekly according to individual clinical protocols.

Find a Location

Who is running the clinical trial?

University of British ColumbiaOTHER
1,381 Previous Clinical Trials
1,951,155 Total Patients Enrolled
Women's College HospitalLead Sponsor
98 Previous Clinical Trials
38,597 Total Patients Enrolled
McGill University Health Centre/Research Institute of the McGill University Health CentreOTHER
430 Previous Clinical Trials
154,632 Total Patients Enrolled

Media Library

Broadband UVB phototherapy (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT04818138 — N/A
Atopic Dermatitis Research Study Groups: Narrowband UVB, Broadband UVB
Atopic Dermatitis Clinical Trial 2023: Broadband UVB phototherapy Highlights & Side Effects. Trial Name: NCT04818138 — N/A
Broadband UVB phototherapy (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04818138 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are enrolled in the current clinical trial?

"Indeed, clinicaltrials.gov attests that this research effort is still ongoing and recruiting volunteers. The trial was initially posted on September 27th 2021 and the latest edits were made on March 11th 2022; 120 participants are needed from 1 facility to complete the study."

Answered by AI

Is it still feasible to join this research experiment?

"Confirmed, the clinical trial is still enrolling. The original post date was September 27th 2021 and its most recent edit occurred on March 11th 2022 according to information available at clinicaltrials.gov."

Answered by AI
~49 spots leftby Jun 2025