Treatment for Eczema

1
Effectiveness
1
Safety
Women's College Hospital, Toronto, Canada
Eczema+4 More
Eligibility
18+
All Sexes
Eligible conditions
Eczema

Study Summary

This study is evaluating whether a form of phototherapy is more effective than another form of phototherapy for people with eczema.

See full description

Eligible Conditions

  • Eczema
  • Skin Diseases
  • Dermatitis
  • Eczema, Infantile
  • Dermatitis, Dermatitis Atopic
  • Dermatitis, Atopic

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 1 primary outcome, 5 secondary outcomes, and 4 other outcomes in patients with Eczema. Measurement will happen over the course of Week 12.

Week 12
Change in the patient global assessment scale from baseline
Mean change in EuroQol-5D-5L (EQ5D-5L) from baseline
Mean change in body surface area (BSA) from baseline
Mean change in the Dermatology Life Quality Index (DLQI) from baseline
Mean change in the Eczema Area and Severity Index (EASI) from baseline
Mean change in the Patient Oriented Eczema Measure (POEM) from baseline
Mean change in the Peak Pruritus Numeric Rating Scale (PP-NRS) from baseline
Mean change in the Recap of atopic eczema (RECAP)
Proportion of patients achieving a validated Investigator Global Assessment (vIGA) score of 0 or 1 with a ≥ 2 point improvement from baseline
Withdrawal from phototherapy due to adverse events

Trial Safety

Safety Estimate

1 of 3

Trial Design

2 Treatment Groups

Narrowband UVB

This trial requires 120 total participants across 2 different treatment groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Narrowband UVB
Device
Narrowband UVB phototherapy (full body) administered three times weekly according to individual clinical protocols.
Broadband UVB
Device
Broadband UVB phototherapy (full body) administered three times weekly according to individual clinical protocols.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: week 12
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly week 12 for reporting.

Who is running the study

Principal Investigator
A.
Aaroncker, Scientist
Women's College Hospital

Closest Location

Women's College Hospital - Toronto, Canada

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
The Validated Investigator Global Assessment score is 3 or 4 out of 4. show original
The person has a moderate to severe disease, even though they have tried topical therapy. show original
The Eczema Area and Severity Index (EASI) score is ≥7.1. show original
Atopic dermatitis is a skin condition that is characterized by a chronic, relapsing rash. show original

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can eczema be cured?

Add answer

While eczema cannot be cured, its severity can be significantly reduced with suitable treatment. Patients should be aware that there are effective treatments for most eczematous conditions, provided that their condition becomes properly diagnosed.

Unverified Answer

What causes eczema?

Add answer

There is no single environmental cause of eczema and it results from a combination of environmental and individual factors. Exposure to certain kinds of pollutants appear to be one of the major factors in the causation of eczema, especially allergic eczema.\n

Unverified Answer

What are common treatments for eczema?

Add answer

A major portion of the patients in our sample had no medications at all. Most of the patients who reported using medicines did so cautiously and experienced only limited success. A substantial proportion of the women reported use of medication at least in the past for at least 3 weeks. Most of the patients had one or more of the following triggers for an eczematous response: allergens, infection, occupational exposures, stress, cold weather, sunlight, stress, emotional stress, dehydration, excessive drinking, smoking, drugs, or any combination of them.

Unverified Answer

How many people get eczema a year in the United States?

Add answer

About 5% of US children (14--19.9 million) are afflicted by atopic dermatitis, which accounts for over 25 million office visits per year. It may be prudent for physicians to consider treatment options in atopy-prone children with moderate-to-high severity of dermatitis.

Unverified Answer

What are the signs of eczema?

Add answer

There are various signs and symptoms of eczema. Each clinical manifestation of eczema has its own characteristic signs and symptoms that can be identified to the dermatologist.\n

Unverified Answer

What is eczema?

Add answer

Eczema affects approximately 20% of people aged 3-4 and is a major cause of childhood and school absenteeism. It has a range of severity, presenting as mild, moderate or severe disease. Eczema can disrupt the normal life of children and family members. It is important to consider eczema as an illness as the impact on quality of life can be substantial. In a recent study, findings showed that there is significant variation in the severity of eczema across different family and individual characteristics and that the severity can be estimated easily.

Unverified Answer

What is the primary cause of eczema?

Add answer

Eczema is caused by various mechanisms, some of which have a genetic basis, while others are lifestyle related. The use of sun protective clothing reduces the risk of developing eczema in children and young adults. This reduces the effects of solar radiation. A genetic component to eczema seems unlikely. For most children the cause of eczema is unknown and therefore there are no conclusive answers available to date.

Unverified Answer

What does treatment usually treat?

Add answer

I've tried everything for eczema - from using salicylates to using salicylic acid. Everything I used hasn't proven effective for me but the key to most good treatments that have failed for me is to find the correct amount (and type) of medication. And for eczema (and everything else) you need a good practitioner who has all the tools for the job - one who can work with you to find the right drug and amount to match your needs.\n

Unverified Answer

Is treatment safe for people?

Add answer

The majority of respondents said that their eczema had a moderate to very small improvement, with a significant minority having a completely unaltered condition. We observed no major adverse events during the survey period. The potential for severe infection with treatment is also an important consideration, as is the potential for adverse drug reactions with the use of the topical medications. However, further research is needed to assess the safety of medications used, to assess the risk of infection with treatments and to identify the risks of treatment, particularly if this involves steroids.

Unverified Answer

Has treatment proven to be more effective than a placebo?

Add answer

A combination of topical and systemic treatments is the most common treatment approach. Topical medications have proven to be more effective than a placebo in treatment of localized acute flares of eczema, or in decreasing the need for multiple topical therapies

Unverified Answer

Is treatment typically used in combination with any other treatments?

Add answer

The patients reported that they were taking several complementary treatments, almost exclusively OTC. This finding highlights the need to make treatment of allergic rhinitis more integrated when treating severe to debilitating symptoms.

Unverified Answer

What is the average age someone gets eczema?

Add answer

The disease commonly occurs between the ages of 3 and 6 years old. People between the ages of 6 and 15 tend to be more severe cases. Most severe cases appear between the ages of 16 and 50. The rate of occurrence varies by population based on age. In Western countries, the disease occurs most frequently between the ages of 0 and 3 years. In China, the disease occurs the most commonly between the ages of 6 and 18 years. In the United Kingdom, the disease is more commonly seen between the ages of 3 and 6 years old. In the United States, the disease is most commonly seen between the ages of 0 and 3 years old but it tends to occur more aggressively in older people.

Unverified Answer
See if you qualify for this trial
Get access to this novel treatment for Eczema by sharing your contact details with the study coordinator.