This trial is evaluating whether Ketamine Hydrochloride will improve 2 primary outcomes and 3 secondary outcomes in patients with Drug Resistant Epilepsy. Measurement will happen over the course of week 18.
This trial requires 15 total participants across 1 different treatment group
This trial involves a single treatment. Ketamine Hydrochloride is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"The latest studies show that ketamine in a low-dose protocol has efficacy as a second-line treatment for refractory partial seizures and as an adjunct treatment to topiramate in children." - Anonymous Online Contributor
"There are no effective options for the treatment of drug resistant childhood epilepsy. Treatment is primarily aimed to reduce seizure-related damage and improve quality of life. This article describes the treatment approach that is most commonly used to treat such patients." - Anonymous Online Contributor
"With appropriate treatment, seizure control is obtained in almost all patients with drug resistant epilepsy, and thus it can not be stated that the disease cannot be cured." - Anonymous Online Contributor
"Drugs resistant epilepsy is an important and ongoing clinical challenge. Many people that have epilepsy will be unable to obtain the optimum treatment due to adverse effects. New and improved approaches to the treatment of resistant epilepsy are needed and need to be urgently developed." - Anonymous Online Contributor
"The drug resistance is caused by the disease itself or by the treatment the patients received. Patients in whom the disease and treatment had not caused the drug resistance exhibited good results with the S/T/T combination strategy compared with the other 2 strategies." - Anonymous Online Contributor
"Although seizures generally improve with treatment, they may recur in patients who have responded favorably to the initial medications. Patients need to be closely monitored for treatment failure." - Anonymous Online Contributor
"Approximately 50,000 adults in the United States are diagnosed with drug resistant epilepsy a year. This makes up 2.5% of adult patients, a rate comparable to that in other countries. The incidence of drug resistant epilepsy was significantly higher in adults aged 50 and above." - Anonymous Online Contributor
"In a recent study, findings demonstrated that ketamine hydrochloride had one of three most common side effects, anxiety or tension, nightmares, and hallucinations or dream-related behaviors. However, the frequency of serious side effects of ketamine hydrochloride was low in this study." - Anonymous Online Contributor
"Ketamine is usually recognized as one of the most frequently prescribed drugs in anesthesia. A recent epidemiologist survey of 6,000 hospitalized patients in China disclosed the low incidence (0.12%) in our study area. The adverse effects usually observed after the use of ketamine are rare, and ketamine is less associated with the most severe adverse effects than propofol or benzodiazepines. Further studies are needed." - Anonymous Online Contributor
"The present retrospective survey demonstrated that ketamine in the form of the HCl salt with oral antiepileptic drugs is used in combination in few epilepsy centres. In contrast to reports in the literature, the present data revealed that ketamine is rarely used in combination with benzodiazepines. On the contrary, we found that the majority of centres often use a benzodiazepin/ketamine co-administration strategy." - Anonymous Online Contributor
"In a recent study, findings support that ketamine may be an antidepressant adjuvant in patients with treatment-resistant epilepsy, therefore it may be considered in addition to currently available antidepressant drugs for treatment-resistant depression. These effects may occur not only as a direct effects of ketamine hydrochloride but also as a result of ketamine hydrochloride's interactions with other medications. For this reason, patients should be monitored carefully when taking ketamine hydrochloride and should not stop taking ketamine hydrochloride or take additional ketamine hydrochloride while on other treatments or medications." - Anonymous Online Contributor
"The most common side effects of ketamine were sleepiness and dizziness, followed by a reduction in muscle tone (paresis), but these were not severe enough to discontinue use or warrant admission to a medical facility. Patients with a history of panic attacks reported improvement on their anxiety level after this drug treatment. Ketamine was also helpful in the treatment of patients with hyperactive and/or restless legs syndrome. The usefulness of ketamine in treating the restless legs syndrome cannot be established unequivocally. Although ketamine has been demonstrated to produce sedation and amnesia, it is not known whether this occurs as a consequence of its stimulant effects or is an active property of ketamine." - Anonymous Online Contributor