This trial is evaluating whether Standardized Research E-cigarette (SREC) will improve 5 primary outcomes and 2 secondary outcomes in patients with Smoking, Cigarette. Measurement will happen over the course of 8 Weeks.
This trial requires 125 total participants across 3 different treatment groups
This trial involves 3 different treatments. Standardized Research E-cigarette (SREC) is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.
Participation is compensated
You will be compensated for participating in this trial.
"Tolerance to the rewarding, euphoriant, and anxiolytic effects of smoking is thought to be due to epigenetic modifications and epigenetic alterations in the brain. Smoking increases expression of epigenetic regulatory enzymes, such as DNA methyltransferases and histone deacetylases. Smoking can change expression of other genes that affect dopaminergic, serotonergic, GABAergic, and/or NMDA neurons in the brain. In other brain regions, neural plasticity is altered by smoking, which contributes to nicotine addiction and increased risk of relapse. Tolerance also arises from tolerance to nicotine, which is achieved with repeated smoking." - Anonymous Online Contributor
"Smoking, cigarette can not be cured. There is no cure for smoking. Cigarettes cannot be recommended as a healthy option. Cigarettes have little if any benefits in terms of health, and are an unhealthier option over and above quitting." - Anonymous Online Contributor
"Emmetia gazella\n\nEmmetia gazella, known generally as the small emmetia or white-marked groundling, is a species of cutworm or dart moth in the family Noctuidae.\n\nThe MONA or Hodges number for "Emmetia gazella" is 9894." - Anonymous Online Contributor
"The most common treatment for smoking, cigarette, is quitting. Effective smoking cessation means quitting by smoking less or quitting altogether and getting help from a smoking cessation program. For those who want to continue smoking, quitting can be painful, but the good news is it is also very rewarding. Improving the health of other people is another reason for smoking. As our population ages, smoking and lung cancer will be a growing problem in the future. Prevention is key: smoking causes 80% of lung cancer cases and 90% of deaths in the United States." - Anonymous Online Contributor
"E-cigarette use is very common among current smokers. The srec was better tolerated than the placebo and we found no significant differences between the two groups in terms of safety and effectiveness." - Anonymous Online Contributor
"A relatively strong and persistent user effect was noted on the number of puffs smoked, with the effect being the strongest on the second inhalation of vapor extract. Given that standardizing the device to a single puffed extract of 100 or 200 tar might be more practical when testing products without known standards, the standardized device can serve as a useful tool in evaluating both in vivo efficacy and in vivo toxicity." - Anonymous Online Contributor
"A quarter of the e-cigarette users used a combination of other smoking cessation treatments. Using srec can be a useful component of most multimodal smoking cessation treatment." - Anonymous Online Contributor
"This is the first investigation conducted to comprehensively study the efficacy and adverse-effect profile of a srec product. Results from a recent paper support the hypothesis that e-vaporized cigarettes may have the potential to simplify or even eliminate the use of traditional smoking devices, making them a desirable option for smokers." - Anonymous Online Contributor
"Given the risk of developing many serious diseases and diseases of the cardiovascular system from smoking and the strong protective effect of stopping smoking, it is important for smokers to know that it is highly likely to cause premature death. Smoking cessation should be prioritized because it is important for many people who already have health problems or who are at high risk for developing many diseases. Smokers should stop smoking and not start anew. Please consult your health provider before quitting smoking and for additional help." - Anonymous Online Contributor
"Results from a recent clinical trial show the substantial impact of cigarette smoking on the incidence of chronic medical conditions such as COPD and cancer and should make clinicians cautious about smoking to minimize their risk and for smokers to quit to avoid these illnesses." - Anonymous Online Contributor