This trial is evaluating whether Sparsentan will improve 2 primary outcomes and 10 secondary outcomes in patients with IgA Vasculitis. Measurement will happen over the course of Week 108 post-treatment.
This trial requires 57 total participants across 2 different treatment groups
This trial involves 2 different treatments. Sparsentan is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"In our practice, hypertensive glomerulopathy is not found in any patient under 40 years of age, while in the older population (>50 years), it is frequently found in patients with chronic hypertension. The most likely cause of hyalinosis, segmental glomerular, seems to occur after repeated arterial hypertension in patients aged 20-50 years." - Anonymous Online Contributor
"At present there is no cure for hyalinosis, segmental glomerular in patients who are treated with corticosteroids. But there are some benefits of corticosteroid such as suppression of the disease for 3 to 6 months, alleviating the pain and alleviating the glomerular edema if needed." - Anonymous Online Contributor
"The number [of people getting hyalinosis, segmental glomerular a year in the United States] is not clear, but the absolute number is probably small--at least 10,000 [per year] or fewer. However, because some of these patients are asymptomatic, this number may be an underestimate because many patients are not getting their follow-up care." - Anonymous Online Contributor
"Hyalinosis of the glomerulus is characterized by increased capillary width, subendothelial edema, and hyaline/lipofuscin hyaline content. Segmental glomerular hyalinosis often appears near the hyalinized tuft and may manifest as decreased on glomerular capillary blood volume." - Anonymous Online Contributor
"Hyalinosis, segmental glomerular disease can be differentiated on the basis of clinical and hemodynamic considerations, as well as pathologic findings on light and electron microscopy." - Anonymous Online Contributor
"Hyalinosis of the renal arteries may be treated with balloon-expandable stents. The arteriole should be preserved without aneurysm. Hyalinosis of the renal vein is more common than hyalinosis of the arteries, and may be treated by renal vein embolization." - Anonymous Online Contributor
"Results from a recent clinical trial indicate that it is feasible to conduct a prospective, nonrandomized trial of sCG for patients who meet the trial inclusion criteria. Although the data on long-term progression and survival are limited, they are encouraging." - Anonymous Online Contributor
"This patient demonstrates segmental hyalinosis and hyalinization due to deposition of amyloid. The lack of demonstrable amyloid deposition and segmental glomerulosclerosis suggests a primary hyalinosis or a combination of the two processes. The presence of both processes may also be related to the development of amyloid nephropathy." - Anonymous Online Contributor
"Recent advancements indicate that sparsentan-based treatment can enhance lung function and increase survival in selected ICU patients. Clinicians will have to contend with the need for more patients to be treated and greater complexity in dosing strategies as this drug becomes available in many parts of the world. Sparsentan, a compound that has shown promising effects in non-human primate models of PAH, appears to lead to improved outcomes when used in conjunction with corticosteroids in patients with severe/refractory severe/dominant pulmonary hypertension and is being evaluated in clinical trials." - Anonymous Online Contributor
"Severe hyalinosis can lead to renal failure. The early diagnosis and treatment of hyalinosis and the associated glomerulosclerosis may allow for preservation of renal function. Segmental glomerular hyalinosis, especially when associated with focal or diffuse glomerular sclerosis, is associated with worse outcomes." - Anonymous Online Contributor
"On the basis of this family study, glomerulus-filtration barrier malfunction is not common in hyalinotic segments of glomeruli. If in fact it occurs, it is a late stage abnormality due to a persistent alteration in the podocyte number." - Anonymous Online Contributor
"[The following are common signs and symptoms and complications of Sparsentan in the Multiple Myeloma & Plasma Disorder Clinical Trials] (https://www.ncbi.nlm.nih.gov/books/NBK229445.pdf). \n- Hematology/Oncology (http://www.hgb.nlm.nih.gov/aboutus/pages/aboutHgb.asp\n- "
"Parasitoid wasp\n\nParasitoid wasps are a highly diverse order which includes species parasitizing a variety of different insect species, but generally include parasitoid Hymenoptera." - Anonymous Online Contributor