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Avatrombopag for Thrombocytopenia in Gastrointestinal Cancer (ACT-GI Trial)
ACT-GI Trial Summary
This trial will compare how well these drugs work to treat CIT in patients with GI malignancies receiving chemotherapy.
ACT-GI Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2014 Phase 3 trial • 49 Patients • NCT01438840ACT-GI Trial Design
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Who is running the clinical trial?
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- I have had blood cancer in the past.I can care for myself and doctors expect me to live more than 12 weeks.I received a platelet transfusion within the last 3 days.I am 18 years old or older.I haven't had chemotherapy in the last 14 days, with certain exceptions.I have low platelet counts due to chemotherapy for over a month.I plan to keep my current chemotherapy dose and schedule for at least one more cycle, if my blood platelet count is okay.I have received radiation treatment to my pelvis area of more than 20 Gy.I have had a significant blood clot or artery blockage event.My cancer has spread to my bones or bone marrow.I do not have any unmanaged ongoing illnesses.I have not had significant bleeding in the week before giving my consent.I cannot take medicine by mouth.I have a long-term platelet disorder or low platelet count not caused by CIT.I have taken a medication for platelet increase within the last 14 days.My organs and bone marrow are functioning well.I am currently receiving chemotherapy for a stomach or intestine cancer.I am willing and able to follow the study's requirements.I am on a chemotherapy schedule that repeats every 2, 3, or 4 weeks.
- Group 1: Group A - Avatromopag
- Group 2: Group B - Matching Placebo
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What are the likely hazards associated with Group A - Avatromopag?
"Avatromopag from Group A is rated a 2 on our safety scale due to the Phase 2 trial data, which denotes that it has been tested for security but not yet proven effective."
What are the primary goals of this medical research?
"The primary focus of this 6-week trial is to evaluate the efficacy of CIT Treatment in Avatrombopag. Secondary outcomes include Proportion of Platelet Count Recovery in Placebo Group, Requirement of Platelet Transfusions in Avatrombopag Group, and Requirement of Platelet Transfusions in Placebo Group which are all measured with 95% confidence intervals."
Are there any current openings for participation in this research experiment?
"As indicated by the data on clinicaltrials.gov, recruitment for this medical trial had concluded before March 6th of 2023. The study was initially posted on September 1st, 2023 but is no longer accepting participants at this time. Fortunately, there are 2,664 other trials currently recruiting patients in need of care."
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