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Subcision for Acne Scars
N/A
Waitlist Available
Led By Murad Alam, MD
Research Sponsored by Northwestern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Have bilateral rolling acne scars on each side of their face
Age 18 to 65
Must not have
Subjects who are unable to understand the protocol or to give informed consent
Under 18 years of age
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 36 weeks
Awards & highlights
No Placebo-Only Group
Summary
This trial is testing whether doing a minor surgical procedure called subcision can improve rolling acne scars. Subcision involves using a needle to cut through tough bands under the skin that cause scarring. The goal is to see if this method makes the skin look smoother compared to no treatment.
Who is the study for?
This trial is for adults aged 18 to 65 with rolling acne scars on both sides of their face, who are in good health and have no active acne. Participants must understand the study and give informed consent. It's not for those under 18, pregnant or breastfeeding women, recent Accutane users, individuals prone to severe scarring or with blood diseases like HIV or Hepatitis, or a history of Herpes.
What is being tested?
The trial is testing if multiple subcision treatments can improve the look of rolling acne scars compared to no treatment at all. This pilot study will assess how feasible this procedure is over several visits.
What are the potential side effects?
While specific side effects aren't listed here, subcision procedures may typically cause temporary bruising, swelling, pain at the treated area and risk of infection.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have deep acne scars on both sides of my face.
Select...
I am between 18 and 65 years old.
Select...
I do not have active acne.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I understand the study and can give my consent.
Select...
I am under 18 years old.
Select...
I have a blood disease like HIV or Hepatitis.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline and 36 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 36 weeks
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in acne scarring compared to baseline after treatments
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Multiple SubcisionExperimental Treatment1 Intervention
Subjects will receive multiple subcision treatments to their randomized side of the face 5 times total spaced 4 weeks apart.
Group II: ControlActive Control1 Intervention
Subjects will receive no intervention control on the other side of the face.
Research Highlights
Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for acne scars, such as subcision, work by physically disrupting the fibrous bands that tether the skin down, thereby improving the appearance of depressed scars. Subcision involves inserting a needle under the skin to break up these bands, which allows the skin to lift and smooth out.
This mechanism is crucial for patients because it directly targets the structural cause of atrophic scars, leading to more noticeable and lasting improvements. Other treatments like microneedling and fractional lasers also promote collagen remodeling by creating controlled micro-injuries, which stimulate the skin's natural healing processes.
These methods are important as they enhance skin texture and reduce scar depth, offering significant cosmetic benefits for those affected by acne scars.
Combined subcision, autologous platelet-rich plasma, and CROSS technique in the treatment of atrophic acne scars: Prospective split face study.Safety of Combined Fractional Microneedle Radiofrequency and CO2 as an Early Intervention for Inflammatory Acne and Scarring Treated With Concomitant Isotretinoin.Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne.
Combined subcision, autologous platelet-rich plasma, and CROSS technique in the treatment of atrophic acne scars: Prospective split face study.Safety of Combined Fractional Microneedle Radiofrequency and CO2 as an Early Intervention for Inflammatory Acne and Scarring Treated With Concomitant Isotretinoin.Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne.
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Who is running the clinical trial?
Northwestern UniversityLead Sponsor
1,633 Previous Clinical Trials
956,809 Total Patients Enrolled
3 Trials studying Acne Scars
44 Patients Enrolled for Acne Scars
Murad Alam, MDPrincipal InvestigatorNorthwestern University
69 Previous Clinical Trials
2,575 Total Patients Enrolled
3 Trials studying Acne Scars
44 Patients Enrolled for Acne Scars
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I understand the study and can give my consent.I do not have active or ongoing acne.I am under 18 years old.I am willing and able to give permission for my tissue to be used and to communicate with the research team.I have deep acne scars on both sides of my face.I have a blood disease like HIV or Hepatitis.I am between 18 and 65 years old.I do not have active acne.I have not used Accutane in the last 6 months.
Research Study Groups:
This trial has the following groups:- Group 1: Control
- Group 2: Multiple Subcision
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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