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Behavioural Intervention

Duration difference estimation for Healthy Subjects

N/A

Recruiting

Led By Regina Lapate, Ph.D.

Research Sponsored by University of California, Santa Barbara

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Between the ages of 18 and 45

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion, an average of 12-14 months

Awards & highlights

Study Summary

This trial aims to study how different parts of the brain process emotions and time information to help guide our actions. The researchers will use brain scans and a technique called transcranial magnetic stimulation to investigate how

Who is the study for?

This trial is for healthy individuals interested in participating in a study that examines how the brain processes emotional and temporal information. Participants should be willing to undergo fMRI scans and transcranial magnetic stimulation (TMS). Specific eligibility criteria are not provided.Check my eligibility

What is being tested?

The study is testing how certain brain regions track emotional and time-related information from dynamic events, using fMRI scans while participants view images. The goal is to understand how this informs actions. TMS will be used to explore the causal role of these regions.See study design

What are the potential side effects?

While specific side effects are not listed, typical side effects of fMRI include discomfort from lying still during scanning. TMS may cause mild headaches or scalp discomfort at the stimulation site.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 18 and 45 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion, an average of 12-14 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion, an average of 12-14 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 12-14 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Behavioral response

Multivariate BOLD metrics

Trial Design

1Treatment groups

Experimental Treatment

Group I: Duration difference estimationExperimental Treatment3 Interventions

Participants will view emotional sequences composed of four emotional images. They will be asked to indicate whether the total duration of positive or negative emotional events was longer, by responding with a button press to a contextual cue defining the relevant action (Left vs Right button). The amount of temporal evidence in favor of one valence in a 12-s sequence is varied orthogonally with respect to the (predominant) emotional valence by varying individual picture presentation times. Participants will undergo one fMRI session and 3 TMS+fMRI sessions (2 of the TMS sessions target prefrontal (PFC) sites, and 1 targets a non-PFC control site).

0 / 1Eligibility criteria met

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Who is running the clinical trial?

University of California, Santa BarbaraLead Sponsor

28 Previous Clinical Trials

2,955 Total Patients Enrolled

Regina Lapate, Ph.D.Principal InvestigatorUniversity of California, Santa Barbara

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are new participants still eligible to enroll in this ongoing clinical trial?

"As per clinicaltrials.gov, this medical investigation is currently seeking eligible individuals to enroll. The trial's initial posting was on January 29th, 2024, and the latest update occurred on February 16th of the same year."

Answered by AI

What is the current number of participants being recruited for this clinical study?

"Indeed, details on clinicaltrials.gov indicate that this research trial is actively seeking participants. The study was initially shared on January 29th, 2024 and last revised on February 16th, 2024. It aims to enroll a total of 50 individuals from one designated site."

Answered by AI

For which individuals is participation in this research study deemed appropriate?

"To be eligible for this research study, individuals must be in good health and aged between 18 to 45 years. The trial has an intake capacity of 50 participants."

Answered by AI

Does this study allow individuals who are at least 18 years old to participate?

"Individuals aged between 18 and 45 are sought for this clinical investigation. Notably, there are a total of 66 trials catering to those under 18 years old and an additional 383 studies focused on individuals above the age of 65."

Answered by AI

Recent research and studies

Journal of NeuroscienceJournal

The Organization of Dorsal Frontal Cortex in Humans and Macaques

Sallet, J., R. B. Mars, M. P. Noonan, F.-X. Neubert, S. Jbabdi, J. X. O'Reilly, N. Filippini, A. G. Thomas, and M. F. Rushworth. 2013. “The Organization of Dorsal Frontal Cortex in Humans and Macaques”. Journal of Neuroscience. Society for Neuroscience. doi:10.1523/jneurosci.5108-12.2013.

clinicaltrials.govStudy

LPFC Organization in Emotion-Duration Difference Estimation

Regina Lapate 2024. "LPFC Organization in Emotion-Duration Difference Estimation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06276400.

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